Glimestar-M 3 Tablet

Glimestar-M 3 Tablet is a drug that treats patients suffering from type 2 Diabetes. This medication is used to control diabetes; it is not a cure. This medicine is a combination of two antidiabetic drugs viz, Glimepiride and Metformin. These drugs belong to sulfonylurea and biguanide antidiabetic medicine class. And works by helping the pancreas in releasing insulin.

Glimestar-M 3 Tablet is used concomitantly in combination as alone not either one result in adequate glycemic control. Administration of oral antidiabetic drugs has been reported to be associated with increased cardiovascular mortality as compared to treatment with diet alone or diet plus insulin.

This tablet reduces the blood sugar level. Any form of allergy must be discussed with the doctor. Consult your doctor if you have history of kidney or liver diseases. Hypoglycemia has not been observed with ingestions of up to 85 g of metformin, although lactic acidosis has occurred in such circumstances.

The active constituents are dialyzable with a clearance of up to 170 mL/minute; hemodialysis may be useful for removal of accumulated drug from patients in whom metformin overdosage is suspected

This combination is given to the patients, if patients have not responded to 4 weeks of the maximum dose of metformin monotherapy, consideration to a gradual addition of an oral sulfonylurea while continuing metformin at the maximum dose, even if prior primary or secondary failure to a sulfonylurea has occurred.

This medication makes the skin much more sensitive to the sun. Hence, if you are using this medication, use sunscreen to avoid skin problems. Limit the intake of alcohol during medication. Inform your doctor if you are using any prescribed drugs or diet supplement.

Glimestar-M 3 Tablet shouldn’t be used by pregnant women. If you had a surgery recently, it is advisable not to take this medicine. The starting dose for this tablet is a 1 mg tablet once every day. Glimestar-M 3 Tablet should be stored at a temperature between 20 to 25 degree celsius. Keep it away from heat, moisture and direct sunlight. Keep the drug away from the reach of the children and pets.

The initial and maintenance dosing should be conservative, due to the potential for decreased renal function. Generally, elderly patients should not be titrated to the maximum dose of metformin. Maintain regular dietary intake and exercise routine and always carry a quick source of sugar with you. You may experience side effects during first weeks of therapy (headache, nausea); consult the prescriber if these persist.

• Type 2 Diabetes

• Allergy

• Liver Disease

• Headache

• Hypoglycemia

• Nausea

• Vomiting

• Diarrhoea

• Stomach Pain

• Upper Respiratory Tract Infection

• How long is the duration of effect?

  The medicine remains active in the body for 3 to 4 days after onset of action.

• What is the onset of action?

  The effect can be observed within 3 to 5 days of administration.

• Are there any pregnancy warnings?

  This medicine is not recommended for women who are or may become pregnant.

• Is it habit forming?

  No habit forming tendencies were reported

• Are there any breast-feeding warnings?

  This medicine is not recommended for women who are breastfeeding due to a risk of severe adverse effect to the infant.

• Does this affect kidney function?

  Caution must be taken in patients with kidney disease. The plasma and blood half-life of metformin is prolonged and the renal clearance is decreased in proportion to the decrease in creatinine clearance. Metformin is contraindicated in the presence of renal dysfunction defined as a serum creatinine >1.5 mg/dL in males or >1.4 mg/dL in females or an abnormal creatinine clearance. Adjustment of dose might be needed. Kindly consult your doctor before taking it.

• Does this affect liver function?

  Caution must be taken in patients with liver disease. No studies have been conducted, however, metformin should be avoided because the presence of liver disease is a risk factor for the development of lactic acidosis during metformin therapy. Adjustment of dose might be needed. Kindly consult your doctor before taking it.

• Is It safe with alcohol?

  It is unsafe to consume alcohol while taking this medicine. Kindly consult your doctor before taking it.

• Is it safe to drive while on this medicine?

  This medicine might affect the patients ability to drive . Patient must avoid driving while taking this medicines.

Below is the list of medicines, which have the same composition, strength and form as Glimestar-M 3 Tablet , and hence can be used as its substitute.

• Switglim-M 3Mg/500Mg Tablet

  Akumentis Healthcare Ltd

• Glimiprime M -3 Tablet

  Primus Pharmaceuticals

• Apriglim M 3 Mg/500 Mg Tablet

  Aprica Pharmaceuticals Pvt Ltd

• Are there any missed dose instructions?

  The missed dose can be taken as soon as you remember. If it is time for the next dosage then the missed dose can be skipped.

• Are there any overdose instructions?

  It is recommended to discontinue the medication and contact your doctor immediately if an overdose is suspected.

This tablet lowers the blood glucose by stimulating the release of insulin from pancreatic beta cells. The drug also decreases glucose production in the liver, decreases intestinal absorption of glucose, and improves insulin sensitivity by increasing bodies glucose uptake and utilization.

Whenever you take more than one medicine, or mix it with certain foods or beverages, you"re at risk of a drug interaction.

test

• Interaction with Alcohol

  null

  Incidence of lactic acidosis may be increased; avoid or limit use.

• Interaction with Lab Test

  null

  Information not available.

• Interaction with Medicine

  null

  • Decreased effect: Drugs which tend to produce hyperglycemia (eg, diuretics, corticosteroids, phenothiazines, thyroid products, estrogens, oral contraceptives, phenytoin, nicotinic acid, sympathomimetics, calcium channel blocking drugs, isoniazid) may lead to a loss of glycemic control.
  • Increased effect: Furosemide increased the metformin plasma and blood Cmax without altering metformin renal clearance in a single dose study.
  • Increased toxicity: Cationic drugs (eg, amiloride, digoxin, morphine, procainamide, quinidine, quinine, ranitidine, triamterene, trimethoprim, and vancomycin) which are eliminated by renal tubular secretion could have the potential for interaction with metformin by competing for common renal tubular transport systems.
  • Cimetidine increases (by 60%) peak metformin plasma and whole blood concentrations.

• Interaction with Food

  null

  • Food: Food decreases the extent and slightly delays the absorption. Drug may cause GI upset; take with food to decrease GI upset.
  • Glucose: Decreases blood glucose concentration. Hypoglycemia does not usually occur unless a patient is predisposed. Monitor blood glucose concentration. Exercise caution with administration in patients predisposed to hypoglycemia (eg, cases of reduced caloric intake, strenuous exercise without repletion of calories, alcohol ingestion or when metformin is combined with another oral antidiabetic agent).
  • Vitamin B12: Decreases absorption of Vitamin B12; monitor for signs and symptoms of vitamin B12 deficiency.
  • Folic acid: Decreases absorption of folic acid; monitor for signs and symptoms of folic acid deficiency.

• Interaction with Disease

  Administration of oral antidiabetic drugs has been reported to be associated with increased cardiovascular mortality as compared to treatment with diet alone or diet plus insulin. Metformin is substantially excreted by the kidney - the risk of accumulation and lactic acidosis increases with the degree of impairment of renal function. Patients with renal function below the limit of normal for their age should not receive metformin. In elderly patients, renal function should be monitored regularly. Use of concomitant medications that may affect renal function (ie, affect tubular secretion) may affect metformin disposition. Therapy should be suspended for any surgical procedures. Avoid use in patients with impaired liver function. Metformin should be discontinued at the time of or prior to the procedure in patients undergoing radiologic studies in which intravascular iodinated contrast materials are utilized, and withheld for 48 hours subsequent to the procedure, and reinstituted only after renal function has been re-evaluated and found to be normal.

• Ques : What is Glimestar-M 3 Tablet?

  Ans : Glimestar-M 3 Tablet is a salt which performs its action by increasing the amount of insulin released by the pancreas in order to lower the blood glucose. Glimestar-M 3 Tablet is used to treat conditions such as Type II Diabetes Mellitus.

• Ques : What are the uses of Glimestar-M 3 Tablet?

  Ans : Glimestar-M 3 Tablet is a medication, which is used for the treatment and prevention from conditions such as Type II Diabetes Mellitus. The patient should inform the doctor about any ongoing medications and treatment before using Glimestar-M 3 Tablet to avoid undesirable effects.

• Ques : What are the Side Effects of Glimestar-M 3 Tablet?

  Ans : Glimestar-M 3 Tablet is a medication which has some commonly reported side effects. These side effects may or may not occur always and some of them are rare but severe. This is not a complete list and if you experience any of the below-mentioned side effects, contact your doctor immediately. Here are some side effects of Glimestar-M 3 Tablet which are as follows: Hypoglycemia, Dizziness, Headache, Nausea, Asthenia, Flu like symptoms, Allergic skin reaction, Elevated liver enzymes, Anemia, Jaundice, and Weight gain. It is a list of possible side-effects which may occur due to the constituting ingredients of Glimestar-M 3 Tablet.

• Ques : What are the instructions for storage and disposal Glimestar-M 3 Tablet?

  Ans : Glimestar-M 3 Tablet should be kept in a cool dry place and in its original pack. Make sure this medication remains unreachable to children and pets. The patient should consult a doctor for its further uses and side effects and should inform the doctor about any ongoing medications and treatment before using to avoid undesirable effects. It is a prescribed medication.

• Ques : Should I use Glimestar-M 3 Tablet empty stomach, before food or after food?

  Ans : This medication is to be consumed orally. The salts involved in this medication react properly if it is taken after having food. If you take it on an empty stomach, it might upset your stomach. Please consult the doctor before using Glimestar-M 3 Tablet.

• Ques : How long do I need to use Glimestar-M 3 Tablet before I see improvement of my conditions?

  Ans : There is no specific time duration of using this medication in which you can see improvement in your condition. The doctor will prescribe you the doses according to your condition. It is advised to consult your doctor while you are under the usage of medication, to analyze your improvement and tell whether to stop using Glimestar-M 3 Tablet or not.

• Ques : Is there any food or drink I need to avoid, while taking Glimestar-M 3 Tablet?

  Ans : There is no specific food product to avoid, under usage of this medication. It will be beneficial to keep your diet healthy and to ignore street food in order to avoid any kind of harmful bacterial intake. It is also advised to stay away from drinking and smoking to uplift your health.

• Ques : Will Glimestar-M 3 Tablet be more effective if taken in more than the recommended dose?

  Ans : Please follow the doses of the medication, as prescribed by your doctor. If you take more than the recommended doses of Glimestar-M 3 Tablet, it may cause some side effects. It is advised to ask your doctor to re-examine your condition if the severity in the health is not reducing.

• Ques : Does Glimestar-M 3 Tablet make you sleepy?

  Ans : No, this drug does not cause sleepiness.

• Ques : Is Glimestar-M 3 Tablet safe for kidneys?

  Ans : Yes, this medicine does not affect kidneys in patients with normal kidney function. However, its use should be avoided in patients with severe kidney disease since Glimestar-M 3 Tablet is principally eliminated by the kidneys.

• Ques : Does Glimestar-M 3 Tablet cause memory loss?

  Ans : No, it is not known that Glimestar-M 3 Tablet causes memory loss. However, the consumption of Glimestar-M 3 Tablet may cause low blood sugar which may cause problems with concentration and reduced alertness.

• Ques : What can happen if I take more than the recommended dose of Glimestar-M 3 Tablet?

  Ans : This medicine should be taken strictly as advised by the doctor. Overdose of this drug may decrease your blood sugar levels (hypoglycemia).