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Overview

Glibenclamide

Prescription vs OTC : Prescription by Doctor required

About Glibenclamide

Glibenclamide is used in the treatment of diabetes mellitus. Insulin, a hormone produced by the body metabolizes sugar in the blood. When the body does not produce insulin in the required amounts, the blood sugar level in the body increases. This results in diabetes.

A diabetic patient has to maintain his blood sugar levels by following a healthy lifestyle like avoiding sugar in food. Glibenclamide activates the pancreas to secrete more insulin. This medication is taken alongside a healthy diet. More insulin helps to reduce the level of sugar in the blood.

Consult with your doctor if you have the following conditions – you are pregnant or breast feeding; allergic reactions to a medicine; problems in the kidney or liver. Let your doctor if you are taking other medications before starting a course of Glibenclamide.

Follow the prescribed dosage carefully which is around 5 mg on a daily basis. It is recommended to skip a dose if you have missed one, do not take multiple doses at once. You may experience certain side effects like nausea, constipation, low blood sugar, weight gain and diarrhea after taking this medication. Consult a doctor immediately if you experience these side effects. The side effects generally tend to improve as the body gets used to the medication.

It is advised to store the medication in a dry and cool place. Make sure the medicine is not exposed to direct light.

    Information given here is based on the salt content of the medicine. Uses and effects of the medicine may vary from person to person. It is advisable to consult a Diabetologist before using this medicine.

    What are the uses of Glibenclamide

    • Type 2 Diabetes Mellitus

      Glibenclamide is used for the reduction of blood sugar levels in patients suffering from Type II diabetes mellitus. It is recommended to follow a controlled diet and exercise regularly along with taking this medicine to obtain better results.

    Information given here is based on the salt content of the medicine. Uses and effects of the medicine may vary from person to person. It is advisable to consult a Diabetologist before using this medicine.

    What are the contraindications of Glibenclamide ?

    • Allergy

      This medicine is not recommended for use if you have a known history of allergy to it or any other medicine belonging to the same class which is Sulfonylureas.

    • Diabetic Ketoacidosis

      This medicine is not recommended for use if you have a condition where ketone bodies are present in the urine. It applies to ketoacidosis with or without coma.

    • Type I Diabetes Mellitus

      This medicine is not recommended for use if you suffer from insulin dependent diabetes or gestational diabetes.

    • Bosentan

      This medicine is not recommended for use in patients who are taking Bosentan. The risk of side effects are extremely high when these medicines are used together.

    Information given here is based on the salt content of the medicine. Uses and effects of the medicine may vary from person to person. It is advisable to consult a Diabetologist before using this medicine.

    What are the side effects of Glibenclamide ?

    • Nausea

    • Heartburn

    • Abdominal Fullness

    • Yellow Colored Eyes Or Skin

    • Dark Colored Urine

    • Fever Or Chills

    • Swelling Of Face, Lips, Eyelids, Tongue, Hands And Feet

    • Unusual Bleeding

    • Fast Heartbeat

    • Unusual Tiredness And Weakness

    Information given here is based on the salt content of the medicine. Uses and effects of the medicine may vary from person to person. It is advisable to consult a Diabetologist before using this medicine.

    Key highlights of Glibenclamide

    • How long is the duration of effect?

      The effect of this medicine lasts for an average duration of 24 hours.

    • What is the onset of action?

      The effect of this medicine can be observed within 15-60 minutes of administration.

    • Are there any pregnancy warnings?

      Use of this medicine in pregnant women is not recommended unless absolutely necessary. It should be used only when the benefits clearly outweigh the risks involved. It is advised to consult your doctor before taking this medicine.

    • Is it habit forming?

      No habit forming tendencies were reported.

    • Are there any breast-feeding warnings?

      Use of this medicine is not recommended while breastfeeding. Monitoring of the infant for signs of decreased blood sugar may be required if this medicine is taken. You should consult your doctor before taking this medicine.

    Information given here is based on the salt content of the medicine. Uses and effects of the medicine may vary from person to person. It is advisable to consult a Diabetologist before using this medicine.

    What are the dosage instructions?

    • Missed Dose instructions

      Take the missed dose as soon as you remember with food. However, if it is almost time for the next scheduled dose then the missed dose can be skipped.

    • Are there any overdose instructions?

      Contact a doctor immediately if an overdose is suspected. Symptoms of overdose may include confusion, sweating, weakness, vomiting, fainting, seizures etc.

    Information given here is based on the salt content of the medicine. Uses and effects of the medicine may vary from person to person. It is advisable to consult a Diabetologist before using this medicine.

    Where is the Glibenclamide approved?

    • India

    • United States

    • Japan

    Information given here is based on the salt content of the medicine. Uses and effects of the medicine may vary from person to person. It is advisable to consult a Diabetologist before using this medicine.

    Medicines containing Glibenclamide

    Below is the list of medicines, which contains Glibenclamide as ingredient

    Information given here is based on the salt content of the medicine. Uses and effects of the medicine may vary from person to person. It is advisable to consult a Diabetologist before using this medicine.

    How does this medication work?

    This medication works by lowering the blood sugar levels by stimulating the production of insulin from pancreatic beta cells.

      Information given here is based on the salt content of the medicine. Uses and effects of the medicine may vary from person to person. It is advisable to consult a Diabetologist before using this medicine.

      What are the interactions of Glibenclamide ?

      Whenever you take more than one medicine, or mix it with certain foods or beverages, you"re at risk of a drug interaction.

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      • Interaction with Alcohol

        Ethanol

        Consumption of alcohol in large quantities is not recommended when you are taking this medicine for controlling blood sugar levels. It is recommended to reduce the alcohol intake so that the adverse effects can be avoided. Symptoms of both reduced or elevated blood sugar levels should be reported to the doctor immediately.
      • Interaction with Lab Test

        Lab

        Information not available.
      • Interaction with Medicine

        Atenolol

        Report the use of any blood pressure medication to the doctor before receiving Glibenclamide. You may need a more frequent monitoring of blood glucose levels while taking these medicines together.

        Clarithromycin

        Report the use of any antibiotic medication to the doctor. You may need an adjusted dose of Glibenclamide and more frequent monitoring of blood sugar levels while taking them together.

        Gatifloxacin

        Report the use of either of the medication to the doctor. These medicines should not be used together. Moderate to severe levels of fall in blood sugar have been frequently reported. Sometimes it may also cause an increase in blood sugar levels. Your doctor may prescribe alternatives that do not interact with each other.

        Ethinyl Estradiol

        Report the use of any birth control pill containing Ethinyl estradiol or other related compounds to the doctor. You may need an adjusted dose of Glibenclamide while taking them together.

        Bosentan

        Report the use of either of the medicine to the doctor. These medicines should not be used together as the risk of severe adverse effects are fairly high on co-administration.

        Ibuprofen

        Report the use of Ibuprofen or any other pain medication to the doctor. These medications can cause a fall in blood sugar levels. You may need a dose adjustment and more frequent monitoring of blood sugar levels while taking them together.
      • Interaction with Disease

        Heart Diseases

        This medicine should be administered with extreme caution if you suffer from a disease of heart or blood vessels. Risks of severe to fatal adverse effects are very high in such patients.

        Diabetic Ketoacidosis

        This medicine should not be used in patients having high acid content in blood as the risk of adverse effects are very high.

        Kidney Disease

        This medicine should be administered with extreme caution if you suffer from any disease of the kidneys. You should consult your doctor to make a suitable adjustment in dosage quantity and/or time-interval between two dosages.

        Liver Disease

        This medicine should be administered with extreme caution if you suffer from any disease of the liver. You should consult your doctor to make a suitable adjustment in dosage quantity and/or time-interval between two dosages.

        Hypoglycemia

        This medicine should be administered with caution if you are prone to having episodes of low blood sugar. This population includes diabetics who are also malnourished or those receiving Beta-blocker drugs such as Metoprolol and Propranolol.

        Hemolytic Anemia/G6Pd Deficiency

        This medicine is not recommended for use in people suffering from Hemolytic Anemia. Reporting this condition to the doctor is a must. In such cases, alternate medication not belonging to Sulfonylureas should be considered.
      • Interaction with Food

        Food

        Information not available.

      References

      • Glibenclamide-Drug Information Portal [Internet].druginfo.nlm.nih.gov 2022 [Cited 1 June 2022].Available from:

        https://druginfo.nlm.nih.gov/drugportal/name/glibenclamide

      • Glibenclamide-DrugBank Online [Internet].go.drugbank.com 2022 [Cited 1 June 2022].Available from:

        https://go.drugbank.com/drugs/DB01016

      Disclaimer : The information produced here is best of our knowledge and experience and we have tried our best to make it as accurate and up-to-date as possible, but we would like to request that it should not be treated as a substitute for professional advice, diagnosis or treatment.

      Lybrate is a medium to provide our audience with the common information on medicines and does not guarantee its accuracy or exhaustiveness. Even if there is no mention of a warning for any drug or combination, it never means that we are claiming that the drug or combination is safe for consumption without any proper consultation with an expert.

      Lybrate does not take responsibility for any aspect of medicines or treatments. If you have any doubts about your medication, we strongly recommend you to see a doctor immediately.
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      Written ByDrx Hina FirdousPhD (Pharmacology) Pursuing, M.Pharma (Pharmacology), B.Pharma - Certificate in Nutrition and Child CarePharmacology
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      Reviewed ByDr. Garima SharmaMBBS, Master in Healthcare Administration, Diploma in Occupational HealthGeneral Physician
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