Cosklot Plus 250 Mg/250 Mg Tablet is prescribed to stop heavy bleeding. It works as an antifibrinolytic and thus stops the blood clots from disintegrating very fast, which in turn reduces bleeding.
It is prescribed for short-term use (2 - 8 days) in hemophilia patients, during and following tooth extraction. This helps in the reduction or prevention of haemorrhage. It is also used as an alternative to aminocaproic acid for subarachnoid hemorrhage (SAH).
Patients are generally discouraged from taking Cosklot Plus 250 Mg/250 Mg Tablet if they have/are:
- Allergic to any component present in the drug
- A problem of blood clots that are present in the brain, eye, or lungs.
- Bleeding because of a kidney problem or brain problem.
- Experience irregular bleeding but its reason has not yet been determined
- Currently on birth control, like the pill or even the vaginal ring. This is primarily because such birth controls contains estrogen as well as progestin.
Before you start Cosklot Plus 250 Mg/250 Mg Tablet provide your doctor a detailed medical history of your current health condition. Do not forget to inform him about any allergies you have or conditions like kidney problems and issues with vision. Also inform him if you are with pregnant or planning to conceive in the near future.
Cosklot Plus 250 Mg/250 Mg Tablet should be taken as per the directions given by your doctor. The drug is meant for oral consumption and can be taken before or with a meal. It is best that you swallow the drug whole with the help of water or any other liquid. Avoid crushing or chewing the tablet as your body will not be able to absorb it properly. The drug should only be taken after the start of a menstrual period.
Taking medicines result in some side effects, but most people may not experience any or if they do, the side effects are very minor. Cosklot Plus 250 Mg/250 Mg Tablet can lead to some side effects like- headache, pain in the joints, spasms, onset of sinus congestion, tiredness and pain in the stomach.
Some severe side effects that can result when you take Cosklot Plus 250 Mg/250 Mg Tablet includes allergic reaction, seizures, dizziness and changes in vision. If you experience a major side effect get in touch with your health care provider as soon as possible.
This medication can be utilized in beneath referenced conditions:
Short-Term Management Of Hemorrhage
Acquired Defective Color VisionThis medicine is not recommended for use in people having a defective color vision as it could make toxicity determination very difficult.
Subarachnoid HemorrhageThis medicine is not recommended for use in people who have hemorrhage in the area between the brain and its outer covering.
Obstructive Blood Clotting DisorderThis medicine is not recommended for use in patients having clotting disorders of the heart and blood vessels. The clots may also move from the place of origin and lodge in other locations. It is not recommended for people having the disease in the past or who are at risk of getting it in the future.
How long is the duration of effect?The effect of this medicine lasts for an average duration of 2-10 hours.
What is the onset of action?The effect of this medicine can be observed within 10-30 minutes of intravenous administration. Time taken for the effect to show may increase with other dosage forms.
Are there any pregnancy warnings?Use of this medicine by pregnant women is not recommended unless absolutely necessary. The benefits of medication along with associated risks should be considered before using it. Consult your doctor before taking this medicine.
Is it habit forming?No habit forming tendencies were reported.
Are there any breast-feeding warnings?This medicine can be used by women who are breastfeeding as the risk of adverse effects of nursing infants are less. Consult your doctor before taking this medicine.
Does this affect kidney function?
Dosing adjustment/interval in renal impairment:
- Clcr 50-80 mL/minute: Administer 50% of normal dose or 10 mg/kg twice daily I.V. or 15 mg/kg twice daily orally.
- Clcr 10-50 mL/minute: Administer 25% of normal dose or 10 mg/kg/day I.V. or 15 mg/kg/day orally.
- Clcr <10 mL/minute: Administer 10% of normal dose or 10 mg/kg/dose every 48 hours I.V. or 15 mg/kg/dose every 48 hours orally.
Consult your before taking Cosklot Plus 250 Mg/250 Mg Tablet.
Does this affect liver function?No relevant data available. Consult your doctor before taking Cosklot Plus 250 Mg/250 Mg Tablet.
Is It safe with alcohol?It is found to be unsafe to consume alcohol along with this medicine.
Is it safe to drive while on this medicine?This medicine usually does not affect the consciousness of the patient. Thus patient can drive while taking this medicine.
Below is the list of medicines, which have the same composition, strength and form as Cosklot Plus 250 Mg/250 Mg Tablet , and hence can be used as its substitute.
Missed Dose instructionsTake the missed dose as soon as you remember given that the next scheduled dose is at least 6 hours away. If you missed a scheduled injection of this medicine, then contact your doctor for further instructions.
Overdose instructionsContact a doctor immediately if an overdose with tranexamic acid is suspected.
This medication works by acting on enzyme plasmin which is primarily responsible for the dissolution of clots. It binds to the plasmin receptors and preserves the clot formed. It forms a reversible complex that displaces plasminogen from fibrin resulting in inhibition of fibrinolysis; it also inhibits the proteolytic activity of plasmin
Whenever you take more than one medicine, or mix it with certain foods or beverages, you"re at risk of a drug interaction.
Interaction with Alcohol
Interaction with Lab Test
Interaction with Medicine
TamoxifenReport the use of either of the medicine to the doctor. Since the risk of adverse effects is high, your doctor may determine the best possible course of treatment. It is recommended to take appropriate precautionary measures while taking them together.
Ethinyl EstradiolReport the use of any hormonal contraceptive, irrespective of the form in which it is consumed, to the doctor. Use of these medicines together are not recommended as the risk of adverse effects are significantly high. Report any incidence of chest pain, breathing difficulties, the presence of blood in cough or urine to the doctor on priority.
TretinoinReport the use of either of the medicine to the doctor. Using these medicines together may increase the risks of serious adverse effects especially in the initial stages of treatment. Seek immediate help if you experience symptoms of internal blood clots like shortness of breast, chest pain, presence of blood in urine or cough, swelling of arms and legs.
Factor IX complexReport the use of any medicine used for improving the clot formation process to the doctor. Your doctor may prescribe an alternate medication or schedule the dosing in such a way that there is sufficient time gap between the consumption of these medicines.
ChlorpromazineChlorpromazine if taken along with Cosklot Plus 250 Mg/250 Mg Tablet (may increase cerebral vasospasm and ischemia).
Interaction with Food
Interaction with Disease
Ques: What is Cosklot Plus 250 Mg/250 Mg Tablet?
Ques: What is the use of Cosklot Plus 250 Mg/250 Mg Tablet?
Ques: What are the side effects of Cosklot Plus 250 Mg/250 Mg Tablet?
Ques: Is Cosklot Plus 250 Mg/250 Mg Tablet an over the counter product?
Ques: How long do I need to use Cosklot Plus 250 Mg/250 Mg Tablet before I see improvement in my condition?
Ques: At what frequency do I need to use Cosklot Plus 250 Mg/250 Mg Tablet?
Ques: Should I use Cosklot Plus 250 Mg/250 Mg Tablet empty stomach, before food or after food?
Ques: What are the instructions for the storage and disposal of Cosklot Plus 250 Mg/250 Mg Tablet?
Ques: Can Cosklot Plus 250 Mg/250 Mg Tablet cause pulmonary embolism?
Ques: Can I take Cosklot Plus 250 Mg/250 Mg Tablet for more than 5 days?
Ques: Does Cosklot Plus 250 Mg/250 Mg Tablet affect fertility?
Ques: Can Cosklot Plus 250 Mg/250 Mg Tablet be taken for nose bleeding?
Tranexamic acid- Drug Information Portal [Internet]. druginfo.nlm.nih.gov. 2021 [Cited 25 Nov 2021]. Available from:https://druginfo.nlm.nih.gov/drugportal/name/tranexamic%20acid
TRANEXAMIC ACID injection- Daily Med [Internet]. dailymed.nlm.nih.gov. 2021 [Cited 24 Nov 2021]. Available from:https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=8d732fca-8157-49f9-9f08-acf9afb75aa2
Tranexamic Acid 500mg/5ml Solution for Injection- EMC [Internet]. www.medicines.org.uk. 2018 [Cited 24 Nov 2021]. Available from:https://www.medicines.org.uk/emc/product/3374/smpc
Lybrate is a medium to provide our audience with the common information on medicines and does not guarantee its accuracy or exhaustiveness. Even if there is no mention of a warning for any drug or combination, it never means that we are claiming that the drug or combination is safe for consumption without any proper consultation with an expert.
Lybrate does not take responsibility for any aspect of medicines or treatments. If you have any doubts about your medication, we strongly recommend you to see a doctor immediately.