Repace H Tablet

This is a combination medication which has Losartan and Hydrochlorothiazide as active ingredients. It belongs to the angiotensin II receptor antagonists group of drugs. This medication prevents the blood vessels in your body from narrowing, thus lowering your blood pressure and improving the blood circulation. It can lower the possible risk of a stroke in people suffering from any heart condition.

Apart from that, it can also slow down kidney damage among people with type 2 diabetes. You can take this medicine with as well as without food. It can take 3-6 weeks for your blood pressure to come under control after you have started a course of this medication.

• Hypertension

• Diabetic Nephropathy

• Allergy

• Aliskiren

• Anuria

• Renal Impairment

• Stomach Pain

• Chills

• Difficulty Or Painful Urination

• Fast Heartbeat

• Chest Tightness

• Acid Or Sour Stomach

• How long is the duration of effect?

  This medication is excreted largely in faeces and the effect lasts for a duration of approximately 24 hours.

• What is the onset of action?

  The peak effect of this medication can be observed in 1 to 1.5 hours.

• Are there any pregnancy warnings?

  This medication is not recommended for pregnant women.

• Is it habit forming?

  No habit forming tendency has been reported.

• Are there any breast-feeding warnings?

  This medication is not recommended for women who are breastfeeding.

Below is the list of medicines, which have the same composition, strength and form as Repace H Tablet , and hence can be used as its substitute.

• Losapil H Tablet

  Psychotropics India Ltd

• Dilosar H Tablet

  Theo Pharma Pvt Ltd

• Losalife H Tablet

  Torrent Pharmaceuticals Ltd

• Zilos H 50 Mg/12.5 Mg Tablet

  FDC Ltd

• Lostat H Tablet

  Blue Cross Laboratories Ltd

• Losarb -H 50Mg/12.5Mg Tablet

  Pulse Pharmaceuticals

• Lartan H 50 Mg/12.5 Mg Tablet

  Avinash Health Products Pvt Ltd

• Lopulse H 50mg/12.5mg Tablet

  Hamps India Pvt Ltd

• Alsartan H 50 mg/12.5 mg Tablet

  Aristo Pharmaceuticals Pvt Ltd

• Losartar H Tablet

  Shrrishti Health Care Products Pvt Ltd

• Are there any missed dose instructions?

  The missed dose should be taken as soon possible. It is advisable to skip the missed dose if it's already time for your next scheduled dose.

• Are there any overdose instructions?

  Seek emergency medical treatment or contact the doctor in case of overdose.

This medication displaces angiotensin II with very high affinity from its binding site at the AT1 receptor subtype, which is responsible for the known actions of angiotensin II. Hydrochlorothiazide is a diuretic which inhibits a sodium-chloride symporter SLC12A3 in the distal convoluted tubule to inhibit water reabsorption in the nephron. The symporter reabsorbs sodium and creates an osmotic gradient for water to be reabsorbed, inhibition of which prevents water reabsorption.

Whenever you take more than one medicine, or mix it with certain foods or beverages, you"re at risk of a drug interaction.

test

• Interaction with Alcohol

  Alcohol

  Consumption of alcohol with this medication will lower the blood pressure and can cause dizziness, headache, changes in heart rate. Avoid driving or operating heavy machinery if you have these symptoms.

• Interaction with Lab Test

  Lab

  Information not available.

• Interaction with Medicine

  Aliskiren

  Use of these medicines is not recommended especially in the elderly population with diabetes and kidney disease with CrCl less than 60 ml/min. You experience weakness, confusion, and irregular heartbeat if these medicines are taken together. Regular monitoring of blood pressure and kidney function tests are to be performed. An alternate medicine should be considered under the doctor's supervision.

  Captopril

  Use of these medicines is not recommended as it may increase the risk of kidney impairment and low blood pressure. You may experience weakness, confusion, and irregular heartbeat if these medicines are taken together. Regular monitoring of blood pressure and kidney function tests are to be performed. An alternate medicine should be considered under the doctor's supervision.

  Dexamethasone

  The desired effect of this medication will not obtain if these medicines are taken together. This interaction is more likely to happen if dexamethasone is taken for more than 1 week. Inform the doctor if you have a sudden weight gain, swelling of hands and feet. If coadministration is needed then appropriate dose adjustments are to be made under the doctor's supervision. Regular monitoring of blood pressure and kidney function tests are to be performed.

  Diclofenac

  The desired effect of this medication will not obtain if these medicines are taken together. The risk of kidney impairment will increase if these medicines are taken together especially in elderly population or having pre-existing kidney disease. Inform the doctor if you have an increased or decreased urination and unexplained weight gain or weight loss. Regular monitoring of blood pressure and kidney function tests are to be performed.

  Insulin

  The effect of insulin will increase if these medicines are taken together. You may experience dizziness, headache, sweating if these medicines are taken together. Regular monitoring of blood glucose levels is needed. Suitable dose adjustments or an alternate medicine should be considered under the doctor's supervision.

• Interaction with Disease

  Congestive Heart Failure (Chf)

  This medication is used with caution in patients with congestive heart failure especially in volume or sodium depletion. Transient hypotension is also not a contraindication to further treatment with AR antagonists since therapy can usually be reinstated without difficulty after blood pressure stabilizes.

• Interaction with Food

  Food

  Information not available.