Lybrate Logo
Get the App
For Doctors
Login/Sign-up
tab_logos
About
tab_logos
Feed
Overview

Trenaxa 500 MG Injection

Manufacturer :  Macleods Pharmaceuticals Pvt.Ltd
Medicine Composition :  Tranexamic Acid
Prescription vs OTC : Prescription by Doctor required

About Trenaxa 500 MG Injection

Trenaxa 500 MG Injection is prescribed to stop heavy bleeding. It works as an antifibrinolytic and thus stops the blood clots from disintegrating very fast, which in turn reduces bleeding.

It is prescribed for short-term use (2 - 8 days) in hemophilia patients, during and following tooth extraction. This helps in the reduction or prevention of haemorrhage. It is also used as an alternative to aminocaproic acid for subarachnoid hemorrhage (SAH).

Patients are generally discouraged from taking Trenaxa 500 MG Injection if they have/are:

  • Allergic to any component present in the drug
  • A problem of blood clots that are present in the brain, eye, or lungs.
  • Bleeding because of a kidney problem or brain problem.
  • Experience irregular bleeding but its reason has not yet been determined
  • Currently on birth control, like the pill or even the vaginal ring. This is primarily because such birth controls contains estrogen as well as progestin.

Before you start Trenaxa 500 MG Injection provide your doctor a detailed medical history of your current health condition. Do not forget to inform him about any allergies you have or conditions like kidney problems and issues with vision. Also inform him if you are with pregnant or planning to conceive in the near future.

Trenaxa 500 MG Injection should be taken as per the directions given by your doctor. The drug is meant for oral consumption and can be taken before or with a meal. It is best that you swallow the drug whole with the help of water or any other liquid. Avoid crushing or chewing the tablet as your body will not be able to absorb it properly. The drug should only be taken after the start of a menstrual period.

Taking medicines result in some side effects, but most people may not experience any or if they do, the side effects are very minor. Trenaxa 500 MG Injection can lead to some side effects like- headache, pain in the joints, spasms, onset of sinus congestion, tiredness and pain in the stomach.

Some severe side effects that can result when you take Trenaxa 500 MG Injection includes allergic reaction, seizures, dizziness and changes in vision. If you experience a major side effect get in touch with your health care provider as soon as possible.

    Information given here is based on the salt content of the medicine. Uses and effects of the medicine may vary from person to person. It is advisable to consult a Hematologist before using this medicine.

    What are the uses of Trenaxa 500 MG Injection

    • Short-Term Management Of Hemorrhage

    • Subarachnoid Hemorrhage

    Information given here is based on the salt content of the medicine. Uses and effects of the medicine may vary from person to person. It is advisable to consult a Hematologist before using this medicine.

    What are the contraindications of Trenaxa 500 MG Injection ?

    • Allergy

      This medicine is not recommended for use in patients who have a known history of allergy to tranexamic acid or any other ingredient present in the dosage form.

    • Acquired Defective Color Vision

      This medicine is not recommended for use in people having a defective color vision as it could make toxicity determination very difficult.

    • Subarachnoid Hemorrhage

      This medicine is not recommended for use in people who have hemorrhage in the area between the brain and its outer covering.

    • Obstructive Blood Clotting Disorder

      This medicine is not recommended for use in patients having clotting disorders of the heart and blood vessels. The clots may also move from the place of origin and lodge in other locations. It is not recommended for people having the disease in the past or who are at risk of getting it in the future.

    Information given here is based on the salt content of the medicine. Uses and effects of the medicine may vary from person to person. It is advisable to consult a Hematologist before using this medicine.

    What are the side effects of Trenaxa 500 MG Injection ?

    Information given here is based on the salt content of the medicine. Uses and effects of the medicine may vary from person to person. It is advisable to consult a Hematologist before using this medicine.

    Key highlights of Trenaxa 500 MG Injection

    • How long is the duration of effect?

      The effect of this medicine lasts for an average duration of 2-10 hours.

    • What is the onset of action?

      The effect of this medicine can be observed within 10-30 minutes of intravenous administration. Time taken for the effect to show may increase with other dosage forms.

    • Are there any pregnancy warnings?

      Use of this medicine by pregnant women is not recommended unless absolutely necessary. The benefits of medication along with associated risks should be considered before using it. Consult your doctor before taking this medicine.

    • Is it habit forming?

      No habit forming tendencies were reported.

    • Are there any breast-feeding warnings?

      This medicine can be used by women who are breastfeeding as the risk of adverse effects of nursing infants are less. Consult your doctor before taking this medicine.

    • Does this affect kidney function?

      Dosing adjustment/interval in renal impairment:

      • Clcr 50-80 mL/minute: Administer 50% of normal dose or 10 mg/kg twice daily I.V. or 15 mg/kg twice daily orally.
      • Clcr 10-50 mL/minute: Administer 25% of normal dose or 10 mg/kg/day I.V. or 15 mg/kg/day orally.
      • Clcr <10 mL/minute: Administer 10% of normal dose or 10 mg/kg/dose every 48 hours I.V. or 15 mg/kg/dose every 48 hours orally.

      Consult your before taking Trenaxa 500 MG Injection.

    • Does this affect liver function?

      No relevant data available. Consult your doctor before taking Trenaxa 500 MG Injection.

    • Is It safe with alcohol?

      It is found to be unsafe to consume alcohol along with this medicine.

    • Is it safe to drive while on this medicine?

      This medicine usually does not affect the consciousness of the patient. Thus patient can drive while taking this medicine.

    Information given here is based on the salt content of the medicine. Uses and effects of the medicine may vary from person to person. It is advisable to consult a Hematologist before using this medicine.

    What are the substitutes for Trenaxa 500 MG Injection ?

    Below is the list of medicines, which have the same composition, strength and form as Trenaxa 500 MG Injection , and hence can be used as its substitute.

    Information given here is based on the salt content of the medicine. Uses and effects of the medicine may vary from person to person. It is advisable to consult a Hematologist before using this medicine.

    What are the dosage instructions?

    • Missed Dose instructions

      Take the missed dose as soon as you remember given that the next scheduled dose is at least 6 hours away. If you missed a scheduled injection of this medicine, then contact your doctor for further instructions.

    • Are there any overdose instructions?

      Contact a doctor immediately if an overdose with tranexamic acid is suspected.

    Information given here is based on the salt content of the medicine. Uses and effects of the medicine may vary from person to person. It is advisable to consult a Hematologist before using this medicine.

    Where is the Trenaxa 500 MG Injection approved?

    • India

    • United States

    • Japan

    Information given here is based on the salt content of the medicine. Uses and effects of the medicine may vary from person to person. It is advisable to consult a Hematologist before using this medicine.

    How does this medication work?

    This medication works by acting on enzyme plasmin which is primarily responsible for the dissolution of clots. It binds to the plasmin receptors and preserves the clot formed. It forms a reversible complex that displaces plasminogen from fibrin resulting in inhibition of fibrinolysis; it also inhibits the proteolytic activity of plasmin

      Information given here is based on the salt content of the medicine. Uses and effects of the medicine may vary from person to person. It is advisable to consult a Hematologist before using this medicine.

      What are the interactions of Trenaxa 500 MG Injection ?

      Whenever you take more than one medicine, or mix it with certain foods or beverages, you"re at risk of a drug interaction.

        test
      • Interaction with Alcohol

        Interaction with alcohol is unknown. It is advisable to consult your doctor before consumption.
      • Interaction with Lab Test

        Information not available.
      • Interaction with Medicine

        Tamoxifen

        Report the use of either of the medicine to the doctor. Since the risk of adverse effects is high, your doctor may determine the best possible course of treatment. It is recommended to take appropriate precautionary measures while taking them together.

        Ethinyl Estradiol

        Report the use of any hormonal contraceptive, irrespective of the form in which it is consumed, to the doctor. Use of these medicines together are not recommended as the risk of adverse effects are significantly high. Report any incidence of chest pain, breathing difficulties, the presence of blood in cough or urine to the doctor on priority.

        Tretinoin

        Report the use of either of the medicine to the doctor. Using these medicines together may increase the risks of serious adverse effects especially in the initial stages of treatment. Seek immediate help if you experience symptoms of internal blood clots like shortness of breast, chest pain, presence of blood in urine or cough, swelling of arms and legs.

        Factor IX complex

        Report the use of any medicine used for improving the clot formation process to the doctor. Your doctor may prescribe an alternate medication or schedule the dosing in such a way that there is sufficient time gap between the consumption of these medicines.

        Chlorpromazine

        Chlorpromazine if taken along with Trenaxa 500 MG Injection (may increase cerebral vasospasm and ischemia).
      • Interaction with Food

        Information not available.
      • Interaction with Disease

        Dosage modification required in patients with renal impairment; ophthalmic exam before and during therapy required if patient is treated beyond several days; caution in patients with cardiovascular, renal, or cerebrovascular disease; when used for subarachnoid hemorrhage, ischemic complications may occur.

      FAQs about Trenaxa 500 MG Injection

      • Ques : What is Trenaxa 500 MG Injection?

        Ans : Trenaxa 500 MG Injection is a medication which has Tranexamic Acid as an active factor present in it. This medicine performs its action by preventing bleeding. This tablet is used to treat conditions such as heavy menstrual bleeding, Severe loss of blood, Blood clotting problems, and Swelling in various body parts.

      • Ques : What is the use of Trenaxa 500 MG Injection?

        Ans : Trenaxa 500 MG Injection is a medication, which is used for the treatment and prevention from conditions such as Heavy menstrual bleeding and Severe loss of blood.

      • Ques : What are the side effects of Trenaxa 500 MG Injection?

        Ans : Side effects of Trenaxa 500 MG Injection are Fainting, Unusual pain or swelling in arms or legs, Nausea, Sudden breathlessness, Coughing up of blood, Loose motion, Vomiting, Allergic skin reaction, Pain or feeling of heaviness in the chest, Diarrhea, Blurred vision, Low blood pressure, and Blood vessel obstruction by blood clots.

      • Ques : Is Trenaxa 500 MG Injection an over the counter product?

        Ans : No, Trenaxa 500 MG Injection is not an over the counter product. it is available as a prescription medicine only.

      • Ques : How long do I need to use Trenaxa 500 MG Injection before I see improvement in my condition?

        Ans : In most of the cases, the average time taken by this medication to reach its peak effect is around 6 hours to 1 day. But the same duration is not mandatory for everyone and so, it is not a standard time period for this medication's action. Please consult your doctor, for the time period you need to use this medication.

      • Ques : At what frequency do I need to use Trenaxa 500 MG Injection?

        Ans : This medication is generally used once or twice a day but it is not the standard frequency, for using this medication. It is advised to consult your doctor before the usage, as the frequency also depends on the patient's condition.

      • Ques : Should I use Trenaxa 500 MG Injection empty stomach, before food or after food?

        Ans : This medication is advised to be consumed orally. The salts involved in this medication react properly if it is taken with the food. If you take it on an empty stomach, it might upset the stomach. Please consult the doctor before using it.

      • Ques : What are the instructions for the storage and disposal of Trenaxa 500 MG Injection?

        Ans : This medication contains salts which are suitable to store only at room temperature. Protect it from moisture and light. Keep this medication away from the reach of children. It is advised to dispose of the expired or unused medication, for avoiding its inadequate effect.

      • Ques : Can Trenaxa 500 MG Injection cause pulmonary embolism?

        Ans : The medication promotes blood clotting. It is not known to facilitate a blood clot to travel to the lungs (pulmonary embolism). Pulmonary embolism is not a common side effect in patients taking Trenaxa. However, it may occur in overdosing patients with long bedrest or prone individuals.

      • Ques : Can I take Trenaxa 500 MG Injection for more than 5 days?

        Ans : The dose and duration of Trenaxa 500 MG Injection depends on the type of disease for which it is prescribed. For heavy bleeding during monthly menstruation, it is usually prescribed for up to 5 days.

      • Ques : Does Trenaxa 500 MG Injection affect fertility?

        Ans : No, the medication is not known to have any effect on fertility. It is usually prescribed for heavy menstrual bleeding. Currently, there exists no evidence that suggests interference of this medicine with ovulation (release of eggs from the ovaries).

      • Ques : Can Trenaxa 500 MG Injection be taken for nose bleeding?

        Ans : Yes, the medication can be consumed for nose bleeding as well.

      References

      • Tranexamic acid- Drug Information Portal [Internet]. druginfo.nlm.nih.gov. 2021 [Cited 25 Nov 2021]. Available from:

        https://druginfo.nlm.nih.gov/drugportal/name/tranexamic%20acid

      • TRANEXAMIC ACID injection- Daily Med [Internet]. dailymed.nlm.nih.gov. 2021 [Cited 24 Nov 2021]. Available from:

        https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=8d732fca-8157-49f9-9f08-acf9afb75aa2

      • Tranexamic Acid 500mg/5ml Solution for Injection- EMC [Internet]. www.medicines.org.uk. 2018 [Cited 24 Nov 2021]. Available from:

        https://www.medicines.org.uk/emc/product/3374/smpc

      Disclaimer : The information produced here is best of our knowledge and experience and we have tried our best to make it as accurate and up-to-date as possible, but we would like to request that it should not be treated as a substitute for professional advice, diagnosis or treatment.

      Lybrate is a medium to provide our audience with the common information on medicines and does not guarantee its accuracy or exhaustiveness. Even if there is no mention of a warning for any drug or combination, it never means that we are claiming that the drug or combination is safe for consumption without any proper consultation with an expert.

      Lybrate does not take responsibility for any aspect of medicines or treatments. If you have any doubts about your medication, we strongly recommend you to see a doctor immediately.
      swan-banner
      Sponsored

      Popular Questions & Answers

      View All

      I am on trenaxa this is my 2nd day how much mor...

      related_content_doctor

      Dr. Maneesha Singh

      Gynaecologist

      Why are you taking tranexa on 2nd day of bleeding. Are you having increased fliw thats troubling ...

      I am on trenaxa ,i m taking it for last 3 days ...

      related_content_doctor

      Dr. Balachandran Prabhakaran

      Gynaecologist

      Usually 5-7 days. But if it is excessive bleeding and not getting controlled in a reasonable peri...

      1 am 38 years I hv very heavy bleeding problem ...

      related_content_doctor

      Dr. Inthu M

      Gynaecologist

      Its not safe It causes thrombosis and stoke because of it. only if indicated and that too for a s...

      I used trenaxa mf tables bleeding stop but the ...

      related_content_doctor

      Rubi Kumari

      Gynaecologist

      if after taking trenexa bleeding not stoped then take some hormonal medication and get usg to rul...

      Having bleeding from one month taken trenaxa 50...

      related_content_doctor

      Dr. Upasna Setia

      Gynaecologist

      You need an ultrasound and then further course of treatment can be decided. Kindly get it done an...

      Table of content

      Content Details
      Profile Image
      Written ByDrx Hina FirdousPhD (Pharmacology) Pursuing, M.Pharma (Pharmacology), B.Pharma - Certificate in Nutrition and Child CarePharmacology
      Reviewed By
      Profile Image
      Reviewed ByDr. Garima SharmaMBBS, Master in Healthcare Administration, Diploma in Occupational HealthGeneral Physician
      chat_icon

      Ask a free question

      Get FREE multiple opinions from Doctors

      posted anonymously
      swan-banner