Common Specialities
{{speciality.keyWord}}
Common Issues
{{issue.keyWord}}
Common Treatments
{{treatment.keyWord}}

Can The Immune System Trigger Alzheimer's Disease?

Written and reviewed by
Dr. Deepak Kumar 86% (37 ratings)
M. Ch (Neuro Surgery), MS - General Surgery, MBBS
Neurologist, Gurgaon  •  25 years experience
Can The Immune System Trigger Alzheimer's Disease?

Alzheimer's disease (AD), otherwise called Alzheimer's, is a chronic neurodegenerative disease that gets progressively worse over time. This condition may start with acute anxiety and dementia, for certain patients. It begins gradually and becomes worse after some time. It is the reason behind almost sixty to seventy percent of the dementia cases. The most well known early indication is trouble in remembering recent events and occasions also known as short-term memory loss.

As the disease progresses, indications can include issues with speech, confusion (effortlessly getting lost), mood swings, loss of inspiration, overseeing self-care and behavioural issues. As the patient’s condition worsens, they regularly pull back from family and society. Over time, bodily functions are lost. Despite the fact that the speed of progression of the disease can differ, the average life expectancy is three to nine years.

  • Immunity Matters: Immune cells that ordinarily help us battle off bacterial and viral infections may assume a far more prominent part in Alzheimer's disease than expected. A number of immune system particles have been connected to Alzheimer's disease. Many of them having been identified in the brain tissues of Alzheimer's patients.
  • Neuroinflammation: Neuroinflammation is, by definition, irritation of the sensory or nervous tissue. This term is generally connected with endless aggravation and chronic inflammation. In spite of the fact that we realise that the immune system is in charge of setting off this inflammation, how this happens has not been totally understood yet. The immune system has been seen as the first line of defence to threats and dangers to the brain. It is quickly activated and takes care of the danger with an inflammatory response which causes the condition of Alzheimer’s to worsen.
  • Microglia: Irritation in a neurodegenerative disease like Alzheimer's is driven essentially by immune cells living in the central nervous system, to be specific microglia. With regards to Alzheimer's, microglia cells can detect the presence of protein totals and react to them. It is believed that the development of Alzheimer's disease may originate from the microglia’s lost capacity to react to A-beta accumulation, therefore allowing its aggregation to continue. This view is upheld by genetic studies in patients with Alzheimer's disease portraying transformations in immune molecules that can trade off microglia's responsiveness.
  • Other Signs: Other than genetics, there are different signs that indicate an association with the immune system in the advancement of the disease. These include, for instance, a few immunological links found in the cerebrospinal liquid of Alzheimer's patients from the beginning or epidemiologic proof showing that the prolonged treatment with nonsteroidal mitigating drugs lessens the danger of creating Alzheimer's. Hence, where the immune system acts as a defence mechanism, it can also act as a trigger in some cases that could cause or enhance the Alzheimer’s disease even further.

In case you have a concern or query you can always consult an expert & get answers to your questions!

2114 people found this helpful
Icon

Book appointment with top doctors for Alzheimer's Disease treatment

View fees, clinic timings and reviews