Tadalafil is a medicine that is used to treat sexual ailments in men. It is used to treat symptoms like erectile dysfunction and sexual impotence. It does this by increasing the amount of blood that ultimately reaches the penis. This medicine works by relaxing the muscles around the genital area of men. It does this by preventing Phosphodiesterase-5 from working on the body. This further increases the amount of cyclic guanosine monophosphate (cGMP) present in the body, which ends up relaxing smooth muscles inside blood vessels.
This medicine can also be used to treat problems of the prostrate gland and of passing urine. However, it will not help you in protection against and treatment of sexually transmitted diseases like syphilis. This medicine does not require a doctor’s prescription, but you should talk to a urologist about the dosage you specifically require, as any kind of overdose may be extremely dangerous. It may even cause death. Before you obtain the dosage, make sure to inform your doctor of your medical history and of any drugs you are currently taking. After the prescription, you may take this medicine with or without food and resume sexual activity after about 60 minutes of consumption.
Information given here is based on the salt and content of the medicine. Effect and uses of medicine may vary from person to person. It is advicable to consult a Urologist before using this medicine.
This medicine is prescribed in cases of erectile dysfunction which makes having intercourse difficult for males. Sexual stimulation combined with this medicine can help sustain an erection. Also, it is prescribed for benign prostatic hyperplasia(enlargement of the prostate which makes urinating troublesome), and in cases of extraordinarily high blood pressure in blood vessels of the lungs and right side of the heart.
This medicine should not be used by you if you have had allergy or increased sensitivity to it or its active components in the past.
This medicine should be consumed 2 hours before any sexual activity at the least. The effects of this medicine may persist in your body for about 3 days.
The onset period of this medicine varies according to the mental health and state of the user. The average onset of action is about 2 hours after oral administering of the medicine.
This medicine does not exhibit habit forming tendencies.
Alcohol is not recommended when you are using this medicine. The combination of it with alcohol may cause symptoms like dizziness, exhaustion, lack of focus or understanding, and pains in your head. These, if caused, should be immediately reported to your physician.
This medicine is not advisable to be used when you are pregnant. You must seek medical attention to help you in determining the dosage if you absolutely cannot do without it.
This medicine can absolutely not be used by mothers who are lactating. You should use some other medicine as replacement when you are breastfeeding.
Sufficient information is not available on whether you can drive while on this medicine. Lack of focus caused by this medicine varies from person to person, so you should not drive or operate heavy machinery if you feel drowsy yourself after consuming this drug.
This medicine is not recommended for patients of kidney disease. If you have a less intense degree of kidney disease, you may still take a very muted dose of this medicine, but if your kidneys don’t function at all, you may be prohibited from taking this medicine. Speak to your doctor before you go ahead, in any case.
If you have intense liver disease, you are asked to not take this medicine. You can have lesser doses if your liver ailment is less serious. Consult your doctor before taking any action.
If you have forgotten the timing of a dose, and hence happen to have skipped it, take it as soon as you remember. However, if you are due for your next dose at the time, skip the missed dose altogether.
If you notice symptoms of an overdose, you should seek your doctor’s help immediately.
This medicine interacts with diseases like heart disease, increased blood pressure, ailments of the liver and kidney, seizure disorder and abnormal erections.
This medicine if taken in combination with alcohol may cause abnormally less blood pressure, and fainting, sweating and dizziness along with it. Hence, alcohol use is recommended to be limited when a person is consuming this medicine.
This medicine interacts with other medicines like Amlodipine, Carbamazepine, Ketoconazole, Phenytoin, Nitroglycerin and Cimetidine. This interaction may harm efficiencies of both medicines.
Erectile dysfunction (ed) is an important worldwide health issue that has a significant negative impact on the quality of life and sexual self-confidence of the affected individual. Numerous epidemiological studies report that prevalence of erectile dysfunction (ED) increases with aging. Moreover, complaints of ed even in younger men are becoming more frequent. However, the numbers of men seeking medical attention for ed along with the increased comfort of physicians treating it has resulted in enhanced management of this condition. It is advised to avoid alcohol, smoking and other substances which is a common causative for ED in young individuals. Treatment options include medicinal options like sildenafil and tadalafil. Surgical options are also available.
Disorders of intimate arousal include several aspects of arousal - physical such as genital lubrication, congestion and sensation, subjective such as interest, distress or interpersonal relationship difficulty. Problems of arousal vary among women and can be classified in the following ways:
Common factors for this problem include decrease of estrogens and androgens; diabetes; thyroid and prolactin abnormality, vaginal and urinary tract infections; surgery, radiation, and medication, smoking, alcoholism; chronic diseases and psychological factors such as depression and anxiety. Other factors are negative sexual attitudes, low self-esteem triggered by body image like small breast size, overweight and sexual and childhood abuse. Lack of communication can also affect sexual arousal like if a woman cannot tell her partner how she prefers to be stimulated.
Hyperactive arousal Disorders
Some women experience persistent genital arousal called restless genital syndrome. There is increased genital blood flow in non-sexual situations causing distress. It may be related to depression and anxiety there may be physical causes like vascular, neurologic, pharmacologic, and hormonal. Its treatment involves relaxation exercises, topical anesthetics, avoiding use of medications or herbal and nutritional products. Medical treatment includes antidepressants. If you wish to discuss about any specific problem, you can consult a Sexologist.
Sildenafil (Viagra), whose function is to inhibit a substance called Phosphodiestarase-5 or PDE5 - was initially used only for the treatment of angina pectoris (a cardiovascular problem) and pulmonary hypertension. Incidentally, it was discovered that it could help the issue of erectile dysfunction too, and thus became hugely popular in the late 1990s. The little blue pill, as it was called, ruled more than 50% of the sexual dysfunction market for more than 15 years. However, as its popularity and usage increased, so did the scientific information about this drug, and now there is an increased speculation that it could be contributing to skin cancer, specifically melanoma. This is considered as one of the most dangerous forms of skin cancer and so the safety of Viagra sildenafil came into question.
Research has shown that users of Viagra sildenafil are at a higher risk for developing melanoma. There are reports stating that about 45 million men are at an increased risk of developing melanoma due to associated Viagra sildenafil use. The risk of developing melanoma was found to increase in men using ED drugs by 21%. Though there is no conclusive proof as yet that sildenafil is the cause, research is increasingly pointing out its role in melanoma. For example, PDE5 inhibitors (sildenafil, tadalafil, vardenafil) are known to promote melanin synthesis, which may exacerbate melanoma development.
The analysis of biochemical pathways of this correlation suggests that Viagra sildenafil triggers a special biochemical action involving the growth-stimulating cGMP (cyclic guanosine monophosphate (an intracellular signaling molecule) which in turn promotes the growth of malignant melanoma. In normal cases, the enzyme phosphodiesterase type 5 (PDE5) regulates the cGMP preventing any adverse cellular activity. Sildenafil inhibits the production of this enzyme, and potentiates a specific cGMP-related biochemical mechanism (called cGMP-cGKI pathway) , and thereby contributes to malignant melanoma. This has been proven to happen in mice and is yet to be proven in humans.
However, there are also reports which suggest that this does not happen due to Viagra sildenafil per se, but due to greater exposure to sun, which even otherwise increases the chances of skin cancer in general, and melanoma in particular. The countering theories also say that the population in which skin cancer was detected, comprised mostly of high income individuals who spent a significant amount of time holidaying on beaches and are not connected to the extensive use of Viagra per se.
Therefore, though there is a correlation that has been established, there is no definite proof that Viagra sildenafil causes skin cancer. It is however, advisable to use ED drugs after medical consultation. If a patient has a genetic predisposition to develop melanoma, it is advisable to seek medical advice before the use of ED drugs. Occasional use should not be harmful. Also, when going out in the sun, limiting exposure to direct sun and UV protection should be managed too.