Mikacin 500 MG Injection

Mikacin 500 MG Injection is prescribed to treat a variety of bacterial infections of lungs, skin, abdomen, and blood caused by E.coli, Streptococci, and Enterococci. It is also used to treat bone infections, respiratory tract infections, endocarditis, and septicemia.

This medicine is known to cause serious kidney problems and hearing problems, especially in the elderly population. Do not take this medicine if you have a known allergy to it. Tinnitus or vertigo may be indications of vestibular injury and impending bilateral irreversible damage which may occur, which is a possible adverse reaction of this medication.

Inform your doctor if you feel fullness in the head, change in urinary pattern, the sign of opportunistic infections like sore throat, white plague, mouth sores, chills or vaginal discharge. Be cautious if you have renal damage, as this medicine may worsen your condition. But this effect is usually reversible.

Symptoms of overdose include ototoxicity, nephrotoxicity, and neuromuscular toxicity. Treatment of choice following a single acute overdose appears to be the maintenance of good urine output of at least 3 mL/kg/hour.

Dialysis is of questionable value in the enhancement of aminoglycoside elimination. If required, hemodialysis is preferred over peritoneal dialysis in patients with normal renal function.

Dose and/or frequency of administration must be monitored and modified in patients with renal impairment; drug should be discontinued if signs of ototoxicity, nephrotoxicity, or hypersensitivity occur.

Ototoxicity is proportional to the amount of drug given and the duration of treatment; tinnitus or vertigo may be indications of vestibular injury and impending bilateral irreversible damage; renal damage is usually reversible.

• Intra-Abdominal Infections

• Pneumonia

• Bacteremia

• Respiratory Tract Infection

• Endocarditis

• Allergy

• Impaired Kidney Function

• Blurred Vision

• Dizziness

• Difficulty In Breathing

• Hearing Loss

• Muscle Pain

• Unusual Tiredness And Weakness

• Skin Rash

• Vomiting

• Neurotoxicity

• Ototoxicity

• Nephrotoxicity

• Headache

• How long is the duration of effect?

  This injection is excreted in urine and its effect lasts for a duration of 8 to 12 hours.

• What is the onset of action?

  The maximum effect of this injection is usually observed in 45 to 120 minutes after it is being injected into the muscles. However, the effectiveness varies from one person to another.

• Are there any pregnancy warnings?

  This injection should be ignored during pregnancy. Doctor consultation is necessary.

• Is it habit forming?

  No habit forming tendency has been reported for this medication.

• Are there any breast-feeding warnings?

  This injection is not recommended to the women who are breastfeeding. In a case, if it is crucial to use the medication, then breastfeeding should not be continued. Before using this medication, make sure that consultation from your doctor is taken, which will advise you of all the risks and potential benefits of this medication. The undesired effects such as diarrhea, diaper rash should be monitored in the infant.

• Does this affect kidney function?

  Dose adjustment is needed. If you have renal impairment, consult your doctor before taking this medication.

• Does this affect liver function?

  No related information is available. Kindly consult your doctor before taking this medication.

• Is It safe with alcohol?

  Consumption of this medicine is found to be safe and does not cause any harmful side effects.

• Is it safe to drive while on this medicine?

  This medicine affects the consciousness of the patient. Hence patient must avoid driving while taking this medicine.

Below is the list of medicines, which have the same composition, strength and form as Mikacin 500 MG Injection , and hence can be used as its substitute.

• Micin 500 MG Injection

  Fdc Ltd

• Macmika 500 MG Injection

  Macleods Pharmaceuticals Pvt.Ltd

• La-Mika 500 MG Injection

  Zuventus Healthcare Ltd

• Mikatax 500 MG Injection

  Alkem Laboratories Ltd

• Nikacin 500 MG Injection

  Zydus Cadila

• Are there any missed dose instructions?

  The missed dose of the medication should be taken as soon as you remember it. The missed dose, however, should be skipped if it is near the time of the next dose.

• Are there any overdose instructions?

  Seek emergency medical treatment or contact the doctor in case of an overdose.

This injection belongs to the group of Aminoglycosides. It works by irreversibly binding to 30S ribosomal subunits of the susceptible bacteria and intervenes with the production of essential components required for the growth of bacteria.

Whenever you take more than one medicine, or mix it with certain foods or beverages, you"re at risk of a drug interaction.

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• Interaction with Medicine

  Patients should not use this injection in combination with Ceftriaxone, Ethinyl Estradiol, Furosemide, Aspirin and Adefovir.

  Must avoid concomitant use of these medicines if you are taking Amikacin:

  • Decreased effect of aminoglycoside: High concentrations of penicillins and/or cephalosporins ( in vitro data).
  • Increased toxicity of aminoglycoside: Indomethacin I.V., amphotericin, loop diuretics, vancomycin, enflurane, methoxyflurane; increased toxicity of depolarizing and nondepolarizing neuromuscular blocking agents and polypeptide antibiotics with the administration of aminoglycosides.

• Interaction with Disease

  • Myasthenia Gravis: Inform the doctor if you have any muscular disorders like Myasthenia Gravis or Parkinsonism since this medicine may increase the muscle weakness. An alternate medicine should be considered based on the clinical condition.
  • Impaired Kidney Function: Inform the doctor if you have any kidney disease or if you have been taking NSAIDs for a long time. An alternate medicine should be considered based on the clinical condition.

• Ques : What is Mikacin 500 MG Injection?

  Ans : This injection has Amikacin as an active element present. It performs its action by stopping bacterial growth and preventing the synthesis of essential proteins required by bacteria to carry out vital functions.

• Ques : What are the uses of Mikacin 500 MG Injection?

  Ans : This injection is used for the treatment and prevention from conditions such as bacterial infections, intra-abdominal infection, pneumonia, bacteremia, and bone and joint infections.

• Ques : What are the Side Effects of Mikacin 500 MG Injection?

  Ans : This injection has some commonly reported side effects. Here are some side effects of this injection which are as follows: black or tarry stools, blurred vision, decrease in the frequency of urination, dizziness, difficulty in breathing, hearing loss, muscle pain, etc.

• Ques : What are the instructions for storage and disposal Mikacin 500 MG Injection?

  Ans : This injection should be stored at room temperature, away from heat and direct light. Keep it away from the reach of children and pets.

• Ques : At what frequency do I need to use Mikacin 500 MG Injection?

  Ans : This medication should be taken in the dosage as prescribed by the doctor.

• Ques : Should I use Mikacin 500 MG Injection empty stomach, before food or after food?

  Ans : This medication should be taken after food in a prescribed dosage.

• Ques : Is Mikacin 500 MG Injection safe?

  Ans : Mikacin 500 MG Injection is safe to use in dose and duration prescribed by the healthcare expert. It should be taken exactly as instructed and make sure to not skip any dose.

• Ques : Can I take a higher than the recommended dose of Mikacin 500 MG Injection?

  Ans : Mikacin 500 MG Injection should be used only in the prescribed dosage. An overdosage of this salt can enhance the risk of having an adverse effect. It also increases the risks of side effects.

• Ques : Can I stop taking Mikacin 500 MG Injection when I feel better?

  Ans : It is suggested not to stop taking this drug without informing your doctor. Please make sure that you complete the full course of medication even if you feel better, otherwise, this can worsen your condition.

• Ques : Can I take alcohol while on Mikacin 500 MG Injection?

  Ans : You should limit the consumption of alcohol during the course of treatment. It is because alcohol consumption can worsen your condition as it causes dizziness and sleepiness.

• Amikacin- Drug Information Portal [Internet]. druginfo.nlm.nih.gov. 2019 [Cited 13 December 2019]. Available from:

  https://druginfo.nlm.nih.gov/drugportal/name/amikacin

• Amikacin- DrugBank [Internet]. Drugbank.ca. 2019 [Cited 13 December 2019]. Available from:

  https://www.drugbank.ca/drugs/DB00479

• Amikacin 250 mg/ml Injection- EMC [Internet] medicines.org.uk. 2015 [Cited 13 December 2019]. Available from:

  https://www.medicines.org.uk/emc/product/3784