Gluconorm-G 1 Tablet

Gluconorm-G 1 Tablet is a drug that treats patients suffering from type 2 Diabetes. This medication is used to control diabetes; it is not a cure. This medicine is a combination of two antidiabetic drugs viz, Glimepiride and Metformin. These drugs belong to sulfonylurea and biguanide antidiabetic medicine class. And works by helping the pancreas in releasing insulin.

Gluconorm-G 1 Tablet is used concomitantly in combination as alone not either one result in adequate glycemic control. Administration of oral antidiabetic drugs has been reported to be associated with increased cardiovascular mortality as compared to treatment with diet alone or diet plus insulin.

This tablet reduces the blood sugar level. Any form of allergy must be discussed with the doctor. Consult your doctor if you have history of kidney or liver diseases. Hypoglycemia has not been observed with ingestions of up to 85 g of metformin, although lactic acidosis has occurred in such circumstances.

The active constituents are dialyzable with a clearance of up to 170 mL/minute; hemodialysis may be useful for removal of accumulated drug from patients in whom metformin overdosage is suspected

This combination is given to the patients, if patients have not responded to 4 weeks of the maximum dose of metformin monotherapy, consideration to a gradual addition of an oral sulfonylurea while continuing metformin at the maximum dose, even if prior primary or secondary failure to a sulfonylurea has occurred.

This medication makes the skin much more sensitive to the sun. Hence, if you are using this medication, use sunscreen to avoid skin problems. Limit the intake of alcohol during medication. Inform your doctor if you are using any prescribed drugs or diet supplement.

Gluconorm-G 1 Tablet shouldn’t be used by pregnant women. If you had a surgery recently, it is advisable not to take this medicine. The starting dose for this tablet is a 1 mg tablet once every day. Gluconorm-G 1 Tablet should be stored at a temperature between 20 to 25 degree celsius. Keep it away from heat, moisture and direct sunlight. Keep the drug away from the reach of the children and pets.

The initial and maintenance dosing should be conservative, due to the potential for decreased renal function. Generally, elderly patients should not be titrated to the maximum dose of metformin. Maintain regular dietary intake and exercise routine and always carry a quick source of sugar with you. You may experience side effects during first weeks of therapy (headache, nausea); consult prescriber if these persist.

• Type 2 Diabetes Mellitus

• Liver Disease

• Allergy

• Hypoglycemia

• Nausea

• Diarrhoea

• Stomach Pain

• Headache

• Upper Respiratory Tract Infection

• How long is the duration of effect?

  The medicine remains active in the body for 3 to 4 days after onset of action.

• What is the onset of action?

  The effect can be observed within 3 to 5 days of administration.

• Are there any pregnancy warnings?

  This medicine is not recommended for women who are or may become pregnant.

• Is it habit forming?

  No habit forming tendencies were reported.

• Are there any breast-feeding warnings?

  This medicine is not recommended for women who are breastfeeding due to a risk of severe adverse effect to the infant.

• Is It safe with alcohol?

  It is unsafe to consume alcohol while taking this medicine. Kindly consult your doctor before taking it.

• Is it safe to drive while on this medicine?

  This medicine might affect the patients ability to drive . Patient must avoid driving while taking this medicines.

• Does this affect kidney function?

  Caution must be taken in patients with kidney disease. The plasma and blood half-life of metformin is prolonged and the renal clearance is decreased in proportion to the decrease in creatinine clearance. Metformin is contraindicated in the presence of renal dysfunction defined as a serum creatinine >1.5 mg/dL in males or >1.4 mg/dL in females or an abnormal creatinine clearance. Adjustment of dose might be needed. Kindly consult your doctor before taking it.

• Does this affect liver function?

  Caution must be taken in patients with liver disease. No studies have been conducted, however, metformin should be avoided because the presence of liver disease is a risk factor for the development of lactic acidosis during metformin therapy. Adjustment of dose might be needed. Kindly consult your doctor before taking it.

Below is the list of medicines, which have the same composition, strength and form as Gluconorm-G 1 Tablet , and hence can be used as its substitute.

• Dailyglim M 1mg/500mg Tablet

  Leeford Healthcare Ltd

• Ozomet-G1 Tablet

  Ozone Pharmaceuticals Ltd

• Switglim-M 1/500 Tablet

  Akumentis Healthcare Ltd

• Glemine 1 Mg/500 Mg Tablet

  Icon Life Sciences

• Fordia G 1 Mg/500 Mg Tablet

  Pulse Pharmaceuticals

• Walaphage G 1Mg/500Mg Tablet

  Wallace Pharmaceuticals Pvt Ltd

• Glimivas M 1 Mg/500 Mg Tablet

  Pulse Pharmaceuticals

• Ronyglim-M 1mg/500mg Tablet

  Vanprom Lifesciences Pvt Ltd

• Glimixia-M 1 Tablet

  Wings Biotech Ltd

• Glavin-M 1Mg/500Mg Tablet

  Avin Pharma

• Are there any missed dose instructions?

  The missed dose can be taken as soon as you remember. If it is time for the next dosage then the missed dose can be skipped.

• Are there any overdose instructions?

  Consult your doctor in case of overdose.

This tablet lowers the blood glucose by stimulating the release of insulin from pancreatic beta cells. The drug also decreases glucose production in the liver, decreases intestinal absorption of glucose, and improves insulin sensitivity by increasing bodies glucose uptake and utilization.

Whenever you take more than one medicine, or mix it with certain foods or beverages, you"re at risk of a drug interaction.

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• Interaction with Alcohol

  Incidence of lactic acidosis may be increased; avoid or limit use.

• Interaction with Medicine

  • Decreased effect: Drugs which tend to produce hyperglycemia (eg, diuretics, corticosteroids, phenothiazines, thyroid products, estrogens, oral contraceptives, phenytoin, nicotinic acid, sympathomimetics, calcium channel blocking drugs, isoniazid) may lead to a loss of glycemic control.
  • Increased effect: Furosemide increased the metformin plasma and blood Cmax without altering metformin renal clearance in a single dose study.
  • Increased toxicity: Cationic drugs (eg, amiloride, digoxin, morphine, procainamide, quinidine, quinine, ranitidine, triamterene, trimethoprim, and vancomycin) which are eliminated by renal tubular secretion could have the potential for interaction with metformin by competing for common renal tubular transport systems.
  • Cimetidine increases (by 60%) peak metformin plasma and whole blood concentrations.

• Interaction with Disease

  Administration of oral antidiabetic drugs has been reported to be associated with increased cardiovascular mortality as compared to treatment with diet alone or diet plus insulin. Metformin is substantially excreted by the kidney - the risk of accumulation and lactic acidosis increases with the degree of impairment of renal function. Patients with renal function below the limit of normal for their age should not receive metformin. In elderly patients, renal function should be monitored regularly. Use of concomitant medications that may affect renal function (ie, affect tubular secretion) may affect metformin disposition. Therapy should be suspended for any surgical procedures. Avoid use in patients with impaired liver function. Metformin should be discontinued at the time of or prior to the procedure in patients undergoing radiologic studies in which intravascular iodinated contrast materials are utilized, and withheld for 48 hours subsequent to the procedure, and reinstituted only after renal function has been re-evaluated and found to be normal.

• Interaction with Food

  • Food: Food decreases the extent and slightly delays the absorption. Drug may cause GI upset; take with food to decrease GI upset.
  • Glucose: Decreases blood glucose concentration. Hypoglycemia does not usually occur unless a patient is predisposed. Monitor blood glucose concentration. Exercise caution with administration in patients predisposed to hypoglycemia (eg, cases of reduced caloric intake, strenuous exercise without repletion of calories, alcohol ingestion or when metformin is combined with another oral antidiabetic agent).
  • Vitamin B12: Decreases absorption of Vitamin B12; monitor for signs and symptoms of vitamin B12 deficiency.
  • Folic acid: Decreases absorption of folic acid; monitor for signs and symptoms of folic acid deficiency.

• Ques : What is Gluconorm g 1 tablet?

  Ans : Gluconorm Tablet is used for treating patients, suffering from type 2 Diabetes, who can’t control blood sugar levels through diet and exercise alone. It contains Glimepiride and Metformin as active ingredients. Gluconorm-G 1 Tablet works by increasing the amount of insulin released by the pancreas; decreasing the amount of glucose and controls the amount of glucose in the blood;

• Ques : What are the uses of Gluconorm g 1 tablet?

  Ans : Side effects include a headache, accidental injury, flu, nausea, dizziness. If any of these symptoms occur often or on daily basis, a doctor should be urgently consulted.

• Ques : What are the instructions for storage and disposal Gluconorm g 1 tablet?

  Ans : Gluconorm-G 1 Tablet should be stored at room temperature, away from heat and direct light. Keep it away from the reach of children and pets.

• Ques : How long do I need to use Gluconorm-G 1 Tablet before I see improvement of my conditions?

  Ans : This medication takes 1 or 2 days before you see an improvement in your health conditions.

• Ques : What are the contraindications to Gluconorm-G 1 Tablet?

  Ans : This medication should not be taken if you have Acute myocardial infarction, Cardiovascular collapse, Diabetic ketoacidosis, Hypersensitivity, Hypersensitivity to sulfonamide derivatives, Renal disease, and Septicemia.

• Ques : Is Gluconorm-G 1 Tablet safe to use when pregnant?

  Ans : This medication is not recommended for use in pregnant women unless absolutely necessary. All the risks and benefits should be discussed with the doctor before taking this medicine.

• Ques : Will Gluconorm-G 1 Tablet be more effective if taken in more than the recommended dose?

  Ans : No, taking higher than the recommended dose of this medication can lead to increased chances of side effects such as Allergic, Pancytopenia, Skin reactions, Headache, Accidental injury, Flu syndrome, Nausea, Dizziness, Hypoglycemia, Weight gain, Allergic reactions, Impairment of liver function, Porphyria cutanea tarda, Photosensitivity reactions, Allergic vasculitis, Leukopenia, Agranulocytosis, Aplastic anemia, Thrombocytopenia, etc.

• Metformin- Drug Information Portal [Internet]. druginfo.nlm.nih.gov. 2019 [Cited 26 April 2019]. Available from:

  https://druginfo.nlm.nih.gov/drugportal/name/metformin

• Metformin: Important information you need to know- Drugs Bank [Internet]. drugsbanks.com. 2017 [Cited 26 April 2019]. Available from:

  https://www.drugsbanks.com/metformin/

• Glimepiride- Drug Information Portal [Internet]. druginfo.nlm.nih.gov. 2019 [Cited 29 April 2019]. Available from:

  https://druginfo.nlm.nih.gov/drugportal/name/glimepiride

• Glimepiride- DrugBank [Internet]. Drugbank.ca. 2019 [Cited 16 May 2019]. Available from:

  https://www.drugbank.ca/drugs/DB00222