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Clozapine 100 MG Tablet

Manufacturer: Intas Pharmaceuticals Ltd
Medicine composition: Clozapine
Prescription vs.OTC: Prescription by Doctor required
Last Updated: December 14, 2018

Clozapine 100 MG Tablet works as an antipsychotic drug and controls the chemicals released by the brain to treat mental health problems like schizophrenia and other disorders. The drug is not easily available. Patients can get access to Clozapine 100 MG Tablet only from a certified pharmacy with a specific prescription.

Meant for oral consumption, the drug can be taken with food or without. Be sure to follow instructions as specified on the prescription. Do not take a lower or higher dose without consulting your doctor. You can take the tablet without water, just place it in your mouth and allow it to dissolve. In case you are prescribed only half a tablet. Break the tablet, consume one half and throw the other half away. Clozapine 100 MG Tablet is not meant to be stored once the tablet is removed from the blister pack.

All drugs lead to some side effects and so does Clozapine 100 MG Tablet. Dizziness, tremor in your hands and feet, a bit of weight gain, problems with vision, dry mouth, nausea and constipation are some common side effects of Clozapine 100 MG Tablet that you may experience. If you experience side effects like chest pain along with a serious case of dizziness, sudden coughing along with breathing issues, have a seizure or have any other new symptoms it is best that you seek medical help as soon as possible.

When it comes to dosage, your doctor may initially prescribe about 12.5 mg of Clozapine 100 MG Tablet to be consumed one or two times a day. Depending on your body’s reaction to the drug the doctor may gradually increase the dosage by 25 mg or 50 mg, until you reach to about 300 mg or 450 mg daily by week 2. The maximum dosage that an adult patient may be prescribed is about 900 mg. Do not discontinue Clozapine 100 MG Tablet suddenly as it can result in serious withdrawal symptoms.

Information given here is based on the salt and content of the medicine. Effect and uses of medicine may vary from person to person. It is advicable to consult a Psychiatrist before using this medicine.

Clozapine 100 MG Tablet is used in the treatment of schizophrenia. Delusions, hallucinations, reduced speaking are some of the symptoms of schizophrenia.
Avoid taking this medicine if you have a known allergy to Clozapine 100 MG Tablet or other antipsychotics.
In addition to its intended effect, Clozapine 100 MG Tablet may cause some unwanted effects too. In such cases, you must seek medical attention immediately. This is not an exhaustive list of side effects. Please inform your doctor if you experience any adverse reaction to the medication.

Blurred vision

Major Common


Major Common

Fast heartbeat

Major Common

Shaking of the hands or feet

Major Common


Major Common

Increased salivation

Major Common


Major Less Common

Dry mouth

Major Less Common

Weight gain

Major Rare

Acid or sour stomach

Minor Common

Muscle pain

Minor Less Common

Sore throat

Minor Less Common

How long is the duration of effect?

The effect of this medicine lasts for an average duration of 4 to 12 hours.

What is the onset of action?

The peak effect of this medicine can be observed in 1.5 to 2.5 hours.

Are there any pregnancy warnings?

This medicine should be used with caution in the pregnant women. Discuss with the doctor about benefits overweigh risks before using this medicine.

Is it habit forming?

No habit forming tendency has been reported

Are there any breast-feeding warnings?

This medicine is not recommended in breastfeeding women.
Below is the list of medicines, which have the same composition, strength and form as Clozapine 100 MG Tablet , and hence can be used as its substitute.
Torrent Pharmaceuticals Ltd
Orchid Chemicals & Pharmaceuticals Ltd
Intas Pharmaceuticals Ltd
Bion Thearapeutics

Missed Dose instructions

Take the missed dose as soon as you remember. If it’s almost time for your next dose, skip the missed dose. Do not double your dose to make up for the missed dose.

Overdose instructions

Seek emergency medical treatment or contact the doctor in case of an overdose.


United States


Clozapine 100 MG Tablet belongs to the class atypical antipsychotics. It works by binding to the D2 and serotonin (5HT2A) receptors and inhibits the release of chemical substances thus helps in reducing the psychotic symptoms.
Whenever you take more than one medicine, or mix it with certain foods or beverages, you"re at risk of a drug interaction.

Interaction with Disease


This medicine is not recommended in the patients with dementia-related psychosis as it increases the risk of heart diseases like heart failure and infectious diseases like pneumonia. An alternate medicine should be considered based on the clinical condition.

Interaction with Alcohol


Consumption of alcohol with this medicine is not recommended as it can result in dizziness and difficulty in concentration. Avoid activities that need mental alertness like driving or operating machinery.

Interaction with Lab Test


Information not available.

Interaction with Food


Information not available.

Interaction with Medicine


Clozapine 100 MG Tablet should be used with caution with ketoconazole or other medicines that may cause irregular heart rhythm. Any symptoms of irregular heartbeat, breathing problem should be reported to the doctor immediately. Frequent monitoring of cardiac evaluation tests are to be performed. Suitable dose adjustments or an alternate medicine should be considered based on the clinical condition.


Tramadol may increase the risk of seizures when taken with Clozapine 100 MG Tablet. This interaction is more likely to happen in the elderly population, and in the patients suffering from head injury. Inform the doctor if you are on either of the medicines. An alternate medicine should be considered based on the clinical condition under the doctor's supervision.

Antidiabetic drugs

The desired effect of antidiabetic agents may not be achieved when taken with Clozapine 100 MG Tablet. Regular monitoring of blood glucose levels is necessary. Inform the doctor if you develop any symptoms like excessive thirst, increased in the frequency of urination. Dose adjustments are to be made based on the clinical condition.


You may experience hypotensive effects like dizziness, lightheadedness if these medicines are used together. Regular monitoring of blood pressure is necessary. Appropriate dose adjustments or replacement of the medicine should be made under the doctor's supervision.
Disclaimer: The information produced here is best of our knowledge and experience and we have tried our best to make it as accurate and up-to-date as possible, but we would like to request that it should not be treated as a substitute for professional advice, diagnosis or treatment.

Lybrate is a medium to provide our audience with the common information on medicines and does not guarantee its accuracy or exhaustiveness. Even if there is no mention of a warning for any drug or combination, it never means that we are claiming that the drug or combination is safe for consumption without any proper consultation with an expert.

Lybrate does not take responsibility for any aspect of medicines or treatments. If you have any doubts about your medication, we strongly recommend you to see a doctor immediately.

Popular Questions & Answers

I AM SUFFERING SLEEPLESSNESS ON DURING MORE YEARS, TAKE DRUGS, ie, sulphitac and clozapine and zolfresh.

General Physician, Mumbai
TAKE DRUGS, ie, sulphitac and clozapine and zolfresh.
Dear, it is best not to depend on sleep medicines for sleep disturbance as in long run, they lead to dependency and increased disturbance. Never rely on alcohol for sleep. Some people use alcohol to help them sleep, but that's not a good idea. At ...
1 person found this helpful

For Schizophrenia, I am on Trinicalm plus and Sizopin. My question is :- Is Diabetes at risk with Clozapine? Thanks.

BASM, MD, MS (Counseling & Psychotherapy), MSc - Psychology, Certificate in Clinical psychology of children and Young People, Certificate in Psychological First Aid, Certificate in Positive Psychology, Positive Psychiatry and Mental Health
Psychologist, Palakkad
For Schizophrenia, I am on Trinicalm plus and Sizopin.
My question is :- Is Diabetes at risk with Clozapine?
Dear Lybrate user. I can understand. Recent reports have raised the concern that clozapine increases the risk for diabetes mellitus. Accurate pharmacoepidemiologic data on whether such a hazard exists and its magnitude are needed to enable clinici...

Dear doctor we have a patient of schizophrenia taking clozapine. That is a good medicine but bioavaiability is so low that it has side effects. You are requested to inform us when the nano drug delivery for clozapine can be expected. We will be highly obliged and thankful to you.

MBBS, MD Psychiatry, DNB Psychiatry
Psychiatrist, Nagpur
Oral bioavailability of clozapine is around 25-28% which is less as compared to other drugs. However it is a very good medication fir schizophrenia, no doubts on that. Side effects do not necessarily occur in every patient and it may not be relate...

I am regular patient of schizophrenia last 20 years I was on clozapine 12.5 mg once in night. But now we feel good sleep with clozapine but due to some side effect weight loss ,liver enlarge my Dr. has changed my medicine as risperidone 1 mg .So I am recently taking risperidone but I feel sleeplessness. Sir can I take clozapine sos to skip my risperidone in night once in a week?

MBBS, MRCPsych (UK), CCST (General Adult Psychiatry and Geriatric Psychiatry)
Psychiatrist, Visakhapatnam
It is not advisable to take clozapine only for Sleep. There are several other alternatives to use to improve sleep especially if you find risperidone is helping to improve your condition and there are no major side effects. If so Please stay on ri...

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Table of Content
About Clozapine 100 MG Tablet
When is Clozapine 100 MG Tablet prescribed?
What are the contraindications of Clozapine 100 MG Tablet ?
What are the side effects of Clozapine 100 MG Tablet ?
Key highlights of Clozapine 100 MG Tablet
What are the substitutes for Clozapine 100 MG Tablet ?
What are the dosage instructions?
Where is the Clozapine 100 MG Tablet approved?
How does medicine works?
What are the interactions for Clozapine 100 MG Tablet ?