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BCG

Prescription vs.OTC: Prescription by Doctor required

BCG is a vaccine, the full form of which is Bacillus Calmette Guerin and is used against tuberculosis. It is recommended to be given to healthy babies as a vaccine as close to birth as possible so that they grow immunity against TB. The same drug may be used also in the treatment of bladder cancer. The vaccine is mainly administered in the form of injection. The vaccine is based on the bacterium’s bovine strain. BCG has a protective effect against leprosy as well, but it is not specifically developed as a drug specified for leprosy. It has been one of the most successful immune therapies in the world.

Other than infants, a tuberculosis skin test is should be done before administering BCG.

BCG this immunization process may result in scarring or marks at the site. Sometimes infections around the injection site is developed if it has not been injected properly. Brest or gluteal abscesses can occur in some rare cases. Regional bone infection is one serious implication of BCG. if it is given by mistake to some immune-compromised patient it can cause life threatening infection. Hence proper medical care is obligatory.

Information given here is based on the salt and content of the medicine. Effect and uses of medicine may vary from person to person. It is advicable to consult a Pulmonologist before using this medicine.

tuberculosis (tb)

In addition to its intended effect, BCG may cause some unwanted effects too. In such cases, you must seek medical attention immediately. This is not an exhaustive list of side effects. Please inform your doctor if you experience any adverse reaction to the medication.

Frequent urge to urinate

Difficulty in urination

Injection site redness

Swelling of lymph nodes

Stomach upset

Chills

Is It safe with alcohol?

Interaction with alcohol is unknown. Please consult your doctor.

Are there any pregnancy warnings?

Tubervac 40mg injection may be unsafe to use during pregnancy.
Animal studies have shown adverse effects on the foetus, however, there are limited human studies. The benefits from use in pregnant women may be acceptable despite the risk. Please consult your doctor.

Are there any breast-feeding warnings?

Tubervac 40mg injection is probably safe to use during breastfeeding. Please consult your doctor.

Is it safe to drive while on this medicine?

There is no data available. Please consult doctor before consuming the drug.

Does this affect kidney function?

There is no data available. Please consult doctor before consuming the drug.

Does this affect liver function?

There is no data available. Please consult doctor before consuming the drug.
Below is the list of medicines, which contains BCG as ingredient
Serum Institute Of India Ltd
Serum Institute Of India Ltd
Zydus Cadila
Serum Institute Of India Ltd
Serum Institute Of India Ltd
Serum Institute Of India Ltd
Serum Institute Of India Ltd
Zydus Cadila
BCG is the live attenuated strain of Mycobacerium used to treat bladder cancer. Mechanism of this is under investigation, but possible mechanisms include direct cytotoxicity, secretion of factors like TRAIL, and by direct action of BCG to some extent.
Whenever you take more than one medicine, or mix it with certain foods or beverages, you"re at risk of a drug interaction.

Interaction with Medicine

Mycomune 500Mg Tablet

MOFETYL S 360MG TABLET

Immutil 500Mg Tablet

What are you using BCG for?
Other
bladder cancer
tuberculosis (tb)
How much was the improvement?
Poor
Excellent
Average
How long did it take before seeing improvement?
More than 2 days
Within 2 hours
How frequently did you take this medicine?
Once a day
Not taking on daily level
How did you take this medicine?
With Food
Empty stomach
With or without food
What were the side effects of this medicine?
Other
Frequent urge to urinate
Injection site redness
Disclaimer: The information produced here is best of our knowledge and experience and we have tried our best to make it as accurate and up-to-date as possible, but we would like to request that it should not be treated as a substitute for professional advice, diagnosis or treatment.

Lybrate is a medium to provide our audience with the common information on medicines and does not guarantee its accuracy or exhaustiveness. Even if there is no mention of a warning for any drug or combination, it never means that we are claiming that the drug or combination is safe for consumption without any proper consultation with an expert.

Lybrate does not take responsibility for any aspect of medicines or treatments. If you have any doubts about your medication, we strongly recommend you to see a doctor immediately.

Popular Questions & Answers

My baby got BCG injection and just wanted to know how can the scar will be removed?

Diploma in Child Health (DCH), MBBS
Pediatrician, Delhi
My baby got BCG injection and just wanted to know how can the scar will be removed?
HI saniya usually BCG leave a mild scar which usually fades away with time . so not much cosmetic problem in the later life. so dont worry there is no need to remove it
1 person found this helpful

Hello Dr. Is there any issue if we give BCG vaccine Twice? The problem is we are not sure that the hospital has given BCG to my baby girl.

M.D.( Pediatrics), DCH
Pediatrician,
Hello Dr. Is there any issue if we give BCG vaccine Twice? The problem is we are not sure that the hospital has given...
Ask concern incharge in the hospital, they will help you. Otherwise, wait for a month, it will show up, if no elevated lesion (reddish papule), then you can give BCG once more.
7 people found this helpful

I have a baby boy who born on 17th Feb 2016 We given BCG today i. E 12th March So is there any problem that we given BCG so late Also Describe BCG.

Diploma in Child Health (DCH), MBBS
Pediatrician, Hyderabad
I have a baby boy who born on 17th Feb 2016 We given BCG today i. E 12th March So is there any problem that we given ...
Bcg is given anywhere between first day of birth and one month. So no problem for your baby given after twenty days. Bcg is given as a prophylaxis to prevent tuberculosis (tb) in future. It is given on the left upper arm. After a period of one to three months a nodule forms at the site of injection, sometimes an abscess forms and it heals and ultimately a scar remains permanently. It is given intradermally.
3 people found this helpful

My query is related with BCG vaccination scar/mark. Our baby got vaccinated with BCG after 5 days birth but he did not get the vaccination mark. Should we go for re-vaccination?

Bachelor of Ayurveda, Medicine and Surgery (BAMS)
Ayurveda, Gurgaon
My query is related with BCG vaccination scar/mark. Our baby got vaccinated with BCG after 5 days birth but he did no...
Hi lybrate-user, Don't worry if he did't get the vaccination scar. Scar will appear in most people vaccinated with BCG, but not everyone. If your child did't have this reaction to the vaccine, it does not mean that they have not responded to it. There's no need to re-vaccination.

My kid is born in US. They don’t give BCG vaccination after birth there. Can I get this vaccination done after 6 months in India.

MBBS, FELLOWSHIP IN PAEDIATRICS
Pediatrician, Ghaziabad
My kid is born in US. They don’t give BCG vaccination after birth there. Can I get this vaccination done after 6 mont...
Yes. This vaccination can be given till 5 years of age. If you are planning to live in india then you should vaccinate your baby.

Popular Health Tips

MBBS, PGDDCN
General Physician, Bangalore
Vaccine Schedule

Epi schedules as recommended by govt. Of india 

-birth -15 days- bcg + opv (zero dose)
-6 weeks- opv1 + dpwt1 + hep b1 + hib 1*
-10 weeks- opv2 + dpwt2 + hep b2+ hib 2*
-14 weeks- opv3 + dpwt3 + hep b3+ hib 2*
-9 months- measles vaccine
-15 months-18 months- 1st booster of opv/ dpwt + mmr*
-5 years -6 years- 2nd booster of dpwt
-10 years- tetanus toxoid
-16 years- tetanus toxoid


* these vaccines have been introduced in few states currently, hep b = hepatitis b vaccine.

How Bladder Tumor Can Be Treated?

MBBS, MS - General Surgery, DNB - Urology/Genito - Urinary Surgery
Urologist, Bangalore
How Bladder Tumor Can Be Treated?

The bladder is a hollow storage organ that collects urine from the kidneys and stores it until it can be passed out of the body through the urethra during the process of micturition or urination. It has a thin inner lining of cells called urothelial cells and a thick muscular wall, which exerts pressure to push the urine out of the body.

Causes of Bladder Tumors

In most cases, the bladder tumor develops on the inner layer due to a combination of some of the following factors.

1. Hereditary: A strong family history of cancer predisposes a person to cancer.
2. Gender: Men are 3 times more prone for bladder cancer than women.
3. Ethnicity: White people are more prone for bladder cancer black people.
4. Smoking: Smokers develop bladder cancer 2-6 times more frequently than non-smokers. cigarettes contain toxic, carcinogenic substances which reach the kidney and are stored in the bladder, leading to their damage.
5. Occupational hazards: Some workplaces have a higher likelihood of causing bladder cancers, especially dye and rubber industries. The effects can be damaging, and the person may develop cancers years after the exposure has happened.
6. Recurrent bladder infections: In some people, this can also lead to bladder cancer in the long run.

Types of Bladder Tumor

Depending on the extent of the cancerous spread, it can be of two types:

1. Non-muscle-invasive bladder tumors: The tumor spread is limited to the inner part of the bladder (urothelial cells)
2. Muscle-invasive bladder tumor: The tumor has spread to the thick muscular outer layer. This is more advanced and prognosis is poor compared to the noninvasive type.

The most common and diagnostic symptom of bladder cancer is the presence of blood in the urine, known as hematuria. This will be intermittent and happens whenever the tumor bleeding happens. Other symptoms include pain in the lower abdomen and frequent urination.

Diagnosis

From the most noninvasive to the most invasive diagnostic test, these include:

1. Urine microscopy to detect cancer cells in the urine
2. Cystoscopy A tube inserted into the urethra to look into the inner wall of the bladder is highly diagnostic
3. Ultrasound, CT Scan, and biopsy can also be further used to identify severity of the tumor.

Treatment

Once the tumor is diagnosed, treatment would depend on the severity of the tumor. For both invasive and noninvasive tumors, definitive therapy is surgery, known as transurethral resection of the bladder tumor (TURBT). The cancerous bladder tissue is removed through a cystoscope as done for diagnosis. The bladder is then flushed with chemotherapy agent to kill any residual cancer cells in the bladder. This is then followed by BCG vaccine, which is again done 1 to 4 weeks for several months to avoid recurrence. In some cases, radiotherapy may also be included.

Bladder cancer BCG vaccination is once in a week for 6 weeks. Surgical removal of bladder is the best available treatment for muscle invasive bladder cancer. If you wish to discuss about any specific problem, you can consult a Urologist.

1972 people found this helpful

Causes And Types Of Bladder Tumor!

MBBS, MS - General Surgery, M. Ch. (Urology), DNB (General Surgery), MBA
Urologist, Noida
Causes And Types Of Bladder Tumor!

The urinary bladder is a hollow purse like storage organ which collects urine from the kidneys and stores it until it can be passed out of the body through the urethra during the process of micturition or urination. It has a thin inner lining of cells called urothelial cells and a thick muscular wall, which exerts pressure to push the urine out of the body. 

Causes of Bladder Tumors

In most cases, the bladder tumor develops on the inner layer due to a combination of some of the following factors.

  1. Hereditary: A strong family history of cancer predisposes a person to cancer.
  2. Gender: Men are 3 times more prone for bladder cancer than women. 
  3. Ethnicity: White people are more prone for bladder cancer black people. 
  4. Smoking / Tobacco use: Smokers develop bladder cancer 2-6 times more frequently than non-smokers. Tobacco contain toxic, carcinogenic substances which reach the kidney and are stored in the bladder, leading to cancerous changes in bladder.
  5. Occupational hazards: Some workplaces have a higher likelihood of causing bladder cancers, especially dye and rubber industries. The effects can be damaging, and the person may develop cancers years after the exposure has happened.
  6. Recurrent bladder infections: In some people, this can also lead to bladder cancer in the long run. 

Types of Bladder Tumor Depending on the extent of the cancerous spread, it can be of two types: 

  1. Non-muscle-invasive bladder tumors: The tumor spread is limited to the inner part of the bladder (urothelial cells)
  2. Muscle-invasive bladder tumor: The tumor has spread to the thick muscular outer layer. 

This is more advanced and prognosis is poor compared to the noninvasive type. The most common and diagnostic symptom of bladder cancer is the presence of blood in the urine without pain in abdomen, known as painless hematuria. This is usually intermittent and stops on its own. Therefore any person who is more than 40 year old, has blood in urine, must be checked to rule out bladder tumor. If you miss these early warning symptoms by just thinking simple infection, you may miss the tumor and will be diagnosed later when tumor is advanced. Other symptoms include pain in the lower abdomen and frequent urination

Diagnosis 

From the most non-invasive to the most invasive diagnostic test, these include:

  1. Urine microscopy and cytology to detect blood and cancer cells in the urine 
  2. Ultrasound and CT Scan can define the bladder tumor, its size and spread. 
  3. Cystoscopy and biopsy is when a is tube inserted into the urethra to look into the inner wall of the bladder and biopsy is taken from lesion. It is highly diagnostic and confirmatory

Treatment TURBT

Once the tumor is diagnosed, first step of the treatment is endoscopic surgery known as transurethral resection of the bladder tumor (TURBT). The cancerous bladder lesion is resected and removed through a cystoscope. Muscle tissue from the base of tumor is also resected to check the spread of tumor in the muscle. The bladder is then flushed with chemotherapy agent to kill any residual cancer cells in the bladder.

  • Intravesical BCG Therapy: If muscle is not involved with tumor, this is called superficial tumor. As there is high chance that this tumor may recur or progress, bladder is treated with BCG injection therapy repeatedly for at least 6 weeks to many months. Check cystoscopy is usually done thereafter to check for any recurrence at frequent intervals.
  • Radical Cystectomy with Ileal conduit or Neo-Bladder: If tumor is involving muscle layer of bladder then whole urinary bladder is removed surgically and urine passage is made at abdominal wall using part of intestine called Ileal conduit. Patient has to wear a bag on abdomen to urine collection and discharge. Now-a-days, artificial bladder is made by patients own intestine which functions like normal bladder and patient passes urine per urethra.
  • Radical Radiotherapy: This is also an alternative treatment for muscle invasive bladder cancer where bladder is preserved and treated by radiotherapy. Repeated check cystoscopy is required thereafter to check for recurrence.
  • Chemotherpy: If tumor has advanced to lymph nodes and other body organs, then treatment is chemotherapy where anticancer drugs are injected into veins. In Summary, Bladder cancer is usually caused by Tobacco consumption. Blood in urine even if it stops on its own or by medications, in person over 40 years of age must be evaluated for bladder cancer. In early stage it can be treated by cystoscopy. If it involved muscle, bladder is removed and neo-bladder is made.

In case you have a concern or query you can always consult an expert & get answers to your questions!

3409 people found this helpful

Tuberculosis - 6 Precautionary Measures You Must Follow!

MBBS
General Physician, Ahmednagar
Tuberculosis - 6 Precautionary Measures You Must Follow!

Tuberculosis or TB is an airborne disease that mainly affects the lungs and has the potential to be fatal. People with an impaired immune system such as newborn babies, pregnant women or women who have just delivered a baby, diabetics, cancer patients and HIV positive people are at the highest risk of suffering from this disease. However, this disease can be prevented and treated.

Here are a few ways to protect yourself from this bacterial infection.

  1. Keep your distance: TB is a communicable disease and hence can spread from one person to another. If someone around you suffers from this disease, try limiting your contact with them. In cases where this is not possible, wear protective gloves and a mask to keep yourself safe. Avoid crowded, unhygienic places and always wash your hands with a disinfectant after contact with a TB patient.
  2. Boost your immunity: A strong immune system can fight off TB bacteria and keep you from getting infected. To build a strong immune system, eat plenty of fresh fruits and vegetables along with the required amount so carbohydrates, proteins and fats every day. Along with this, consult your doctor and start taking multivitamins or antioxidants on a daily basis.
  3. Maintain proper hygiene: Keeping your surroundings clean are crucial to the prevention of tuberculosis. Ensure that not only your home is kept clean, but the surrounding area is cleaned as well. Do not allow garbage to accumulate around your house. Make it a habit of washing your hands with disinfectant soap every time you come home and before eating anything.
  4. Vaccinate your children: When getting your children vaccinated, ensure that your child also receives the BCG or Bacillus Calmette-Guerin vaccine that can protect him or her against TB.
  5. Ventilate the house: The bacteria that causes tuberculosis, thrives in stagnant air and enclosed spaces. Hence, open your windows and let some fresh air in. Not only does this prevent the multiplication of bacteria and viruses in your house, it also does not allow your home to have a musty odour.
  6. Follow the complete course of treatment: If you have been diagnosed with TB, it is essential to complete the full course of antibiotics and not stop midway even if the symptoms have disappeared. Not adhering to the prescription gives the bacteria the ability to develop resistance to the drugs. When this resistant bacteria is exhaled it can infect more people with drug-resistant tuberculosis that is harder to cure. If you wish to discuss about any specific problem, you can consult a General Physician.
5621 people found this helpful

Bladder Cancer - Ways That Can Help You Manage!

MBBS, MD-Radio Therapy
Oncologist, Ghaziabad
Bladder Cancer - Ways That Can Help You Manage!

Statistics report an approximate 38.5% of men and women are diagnosed with some type of cancer during their lifetime. Getting widely prevalent, cancer is a deadly disease. However, due to the continuous efforts in the field of medical science, several treatment methods offering positive results are on the evolve.

Scientists have made great progress in discerning the characteristics of normal and cancer cells in the bladder and also an insight into how this helps the cancer cells to grow and spread to other parts of the body. They are now trying to utilize this knowledge for developing new ways that can treat bladder cancer and others.

  1. Screening and diagnostic tests: The newly developed tests are now able to look for different substances in the urine that can help in finding whether there is bladder cancer. They are primarily used for diagnosing bladder cancer or to look for risks and chances of recurrence in individuals who have already been treated. Researchers are now on the way to find out whether these screening tests can help in finding out bladder cancer in people who don't exhibit any signs or symptoms.
  2. Surgical intervention: These days, surgeons are making use of the newer approach to cystectomy where the surgeons use robotic arms for performing the surgery. It is commonly referred to as robotic cystectomy, and it allows the surgeon to operate through small incisions in place of a single large one. It helps the patients to recover much quicker. It can also be used in other forms of cancer such as prostate cancer.
  3. Immunotherapy: There are immunotherapy drugs now available for treating bladder cancer. It is a treatment that uses the immune system of the body for fighting against cancer which is accomplished using substances that restore the immune system to fight the invading cancer cells effectively.
  4. Photodynamic therapy: Photodynamic therapy or PDT is now under study to find out whether it is useful in the treatment of early-stage bladder cancers. In this treatment, the surgeon injects a light-sensitive drug into the bloodstream. After that, a special form of laser light is concentrated to the inner lining of the bladder with the help of the cystoscope. The light alters the composition of the cancer cells which destroys itself.
  5. Intravesical immunotherapy: This is yet another form of immune therapy that has already been used for the treatment of other cancers. BCG is a type of intravesical therapy where a germ is injected in liquid form into the bladder. This causes an attraction of immune cells to the lining of the bladder which invariably kills the cancer cells.
  6. Targeted therapies: As the researchers can gather more information regarding the alterations in bladder cells which cause them to become cancerous, they are also developing the drugs which can be helpful in targeting these changes. They may be effective in conditions where other chemo drugs fail, and they lead to fewer side effects.

Thus, if you are diagnosed with bladder cancer, do not lose hope but persevere and stay positive to get cured.

In case you have a concern or query you can always consult an expert & get answers to your questions!

3200 people found this helpful
Table of Content
About BCG
When is BCG prescribed?
What are the side effects of BCG ?
Key highlights of BCG
Medicines containing BCG
How does medicine works?
What are the interactions for BCG ?