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Sputnik V

Medicine composition: Sputnik V
Prescription vs.OTC: Prescription by Doctor required

Named after the first Russian soviet space satellite Sputnik-1, Sputnik V is the world’s first registered vaccine with a well-studied human adenoviral vector-based platform. It was made by the Gamaleya National Center of Epidemiology and Microbiology in Russia. The vaccine has already been registered in 65 countries and the count is still increasing.

The composition of the vaccine can be categorized into two active and base ingredients. The active components include Serotype 26 and serotype 5 ( modified replication-defective adenovirus ), modified to be incorporated with the protein S-expressing gene of the SARS-CoV-2 virus. The active components are mixed with the base elements like-

  • Tris-(hydroxymethyl)-aminomethane
  • Disodium EDTA dihydrate
  • Polysorbate 80
  • Sucrose
  • Magnesium chloride hexahydrate
  • Sodium chloride
  • Ethanol
  • and Water.

Adenoviruses are non-enveloped double-stranded DNA viruses that cause non-life-threatening infections in the gastrointestinal epithelium, respiratory or ocular in a diverse range of hosts. The infectious Adenoviruses are replaced with a protein from another virus spike, which not only makes it safer but also helps the immune system to produce antibodies.

The technology is easy to engineer and it makes the vaccine faster than any other procedure, as the new vaccine can be created by modifying the initial carrier vector with genetic material from new emerging viruses.

The first dose is composed of Serotype 26 (Ad26) followed by the second dose which is composed of serotype 5 (Ad5) adenovirus. The key to using two different types of adenovirus is to decrease the possibilities of antibody production which is against the adenovirus after the first shot. In case your body develops antibodies that are against the serotype 5 antibodies, the second dose is ineffective on your immune system.

As per the current data, the efficacy rate of Sputnik V against the COVID-19 virus is 91.6%. This is because of the methodology that has been used to make the vaccine. Adenoviral Vector-based vaccines are easy to manufacture and quite effective as they consist of two different types of adenovirus vectors (rAd26 and rAd5) in both of the shots individually. It not only makes it safer than other vaccines available in the market but makes it more effective to produce antibodies in your immune system.

The vaccine is manufactured by RDIF (RDIF, Russia’s sovereign wealth fund) with a joint partnership with approved countries like India, China, South Korea, Brazil, etc., and has been approved for receivers who are and above 18years of age.

Because of the unique nature of the vaccine, It is important to take both shots of the vaccine to achieve the efficacy level. Furthermore, the recommended gap between the two jabs of the Sputnik V vaccine is approximately three weeks or 21 days.

As per the vaccine experts around the globe, the vaccine is expected to provide an optimum amount of protection against the virus, even with the newer strains/mutated versions. Your body responds to vaccination in every case by developing more than one type of antibody that will effectively destroy the virus.

The Russian Gamaleya National Center of Epidemiology and Microbiology vaccine is the first vaccine in the world that has the highest efficacy against coronavirus. Yet the vaccine might have some side effects which can be seen after the first shot of vaccine-

Information given here is based on the salt content of the medicine. Uses and effects of the medicine may vary from person to person. It is advisable to consult a General Physician before using this medicine.

This drug can be used in below-mentioned conditions

  • COVID-19

  • Hypersensitivity

This drug can cause below-mentioned side effects

  • Fatigue

  • Muscle Or Joint Pain

  • Headache

  • Fever Or Chills

  • Nausea Or Vomiting

  • Hemorrhagic Disorder

  • Hypertension

  • Deep Vein Thrombosis

  • Are there any pregnancy warnings?

    This vaccine is found to be safe to be used in pregnant women. Clinical studies are still under process and there could be any unforeseen effect on the fetus which is yet to be identified.

  • Are there any breast-feeding warnings?

    This vaccine is still under clinical trial and for now its effect is unknown in nursing women.

  • Is It safe with alcohol?

    It is advised to avoid alcohol consumption for a brief period of time before getting vaccinated, as it might affect people’s immune responses to the jab.

  • Is it safe to drive while on this medicine?

    This vaccine is not found to affect people's consciousness. If you feel dizzy, then you must avoid driving.

  • Does this affect kidney function?

    Vaccine is safe to be administered to the patient with kidney disease of any severity.

  • LD

    This vaccine has been demonstrated to cause or worsen chronic liver diseases.

  • India

  • United States

  • Japan

Below is the list of medicines, which contains Sputnik V as ingredient

Sputnik V composed of weakened virus to deliver people with the small parts of a pathogen and stimulate the immune system. It reduces the actual time taken for the development of immunity to SARS-CoV-2, the virus responsible for the disease.

Disclaimer: The information produced here is best of our knowledge and experience and we have tried our best to make it as accurate and up-to-date as possible, but we would like to request that it should not be treated as a substitute for professional advice, diagnosis or treatment.

Lybrate is a medium to provide our audience with the common information on medicines and does not guarantee its accuracy or exhaustiveness. Even if there is no mention of a warning for any drug or combination, it never means that we are claiming that the drug or combination is safe for consumption without any proper consultation with an expert.

Lybrate does not take responsibility for any aspect of medicines or treatments. If you have any doubts about your medication, we strongly recommend you to see a doctor immediately.

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Content Details
Written By
PhD (Pharmacology) Pursuing, M.Pharma (Pharmacology), B.Pharma - Certificate in Nutrition and Child Care
Reviewed By
MBBS, Master in Healthcare Administration, Diploma in Occupational Health
General Physician
Table of Content
About Sputnik V
What are the uses of Sputnik V
What are the contraindications of Sputnik V ?
What are the side effects of Sputnik V ?
Key highlights of Sputnik V
Where is the Sputnik V approved?
Medicines containing Sputnik V
How does this medication work?