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Overview

Glipizide

Prescription vs OTC : Prescription by Doctor required

About Glipizide

Glipizide is an oral medication for diabetes which helps to keep your blood sugar level in check by stimulating the pancreas to produce more insulin. This medicine is used along with exercise and diet in the treatment of type 2 diabetes.

Before you start a course of this medication, inform your doctor if you – have liver or kidney problems, diarrhea or intestinal blockage, disorders in the adrenal or pituitary glands, are malnourished, have a history of heart problem. It is strictly recommended to follow a healthy lifestyle to prevent any unwanted spikes in blood sugar.

Do not change the dosage of this medication without consulting the doctor. It is generally taken 30 minutes before a meal. You have to swallow the tablet whole without chewing or crushing it. Taking this medication can result in low blood sugar whose symptoms are irritability, sweating, dizziness, and confusion. Consult a doctor if you experience any of its side effects.

During the course of this medication, it is advisable to avoid alcohol. Alcohol tends to cause interference with diabetes treatment.

    Information given here is based on the salt content of the medicine. Uses and effects of the medicine may vary from person to person. It is advisable to consult a Diabetologist before using this medicine.

    What are the uses of Glipizide

    • Type 2 Diabetes Mellitus

      This medication is used individually or in combination with other medications to lower blood glucose levels in patients with type II diabetes mellitus.

    Information given here is based on the salt content of the medicine. Uses and effects of the medicine may vary from person to person. It is advisable to consult a Diabetologist before using this medicine.

    What are the contraindications of Glipizide ?

    • Allergy

      It is not recommended for use if you have a known history of allergy to Glipizide (the primary constituent of Glipizide) or any other medicine belonging to the group sulphonylurea.

    • Type I Diabetes Mellitus

      This medicine is not recommended for use if you have type I or insulin dependent diabetes mellitus.

    • Diabetic Ketoacidosis

      This medicine is not recommended for use in a patient having high levels of acid content in the blood.

    Information given here is based on the salt content of the medicine. Uses and effects of the medicine may vary from person to person. It is advisable to consult a Diabetologist before using this medicine.

    What are the side effects of Glipizide ?

    • Diarrhoea

    • Dizziness

    • Shaking Of Body

    • Skin Rash

    • Yellow Colored Eyes Or Skin

    • Dark Colored Urine

    • Pain In Upper Abdomen

    • Unusual Bleeding

    • Fever

    • Excessive Air Or Gas In Stomach

    • Hypoglycemia

    • Decreased Heartbeat

    • Elevated Liver Enzymes

    Information given here is based on the salt content of the medicine. Uses and effects of the medicine may vary from person to person. It is advisable to consult a Diabetologist before using this medicine.

    Key highlights of Glipizide

    • How long is the duration of effect?

      The effect of this medicine lasts for 12-24 hours.

    • What is the onset of action?

      The effect of this medicine can be observed within 30 minutes of oral administration.

    • Are there any pregnancy warnings?

      The use of this medicine in pregnant women is not recommended unless absolutely necessary.

    • Is it habit forming?

      No habit forming tendencies were reported.

    • Are there any breast-feeding warnings?

      The use of this medicine is not recommended while breastfeeding.

    • Does this affect kidney function?

      Dose adjustment needed in case of renal impairment.

    • Does this affect liver function?

      Dose adjustment needed in case of hepatic impairment.

    Information given here is based on the salt content of the medicine. Uses and effects of the medicine may vary from person to person. It is advisable to consult a Diabetologist before using this medicine.

    What are the dosage instructions?

    • Missed Dose instructions

      Take the missed dose 30 minutes before the next meal. However, if it is almost time for the next scheduled dose then the missed dose should be skipped to prevent overdosing.

    • Are there any overdose instructions?

      Contact your doctor immediately if an overdose is suspected. Symptoms of overdose may include weakness, shaking of the body, blurred vision, excessive sweating, stomach pain, and seizures. Sometimes, an overdose of Glipizide may cause a rapid fall in blood sugar levels that could be life-threatening.

    Information given here is based on the salt content of the medicine. Uses and effects of the medicine may vary from person to person. It is advisable to consult a Diabetologist before using this medicine.

    Where is the Glipizide approved?

    • India

    • United States

    • Japan

    Information given here is based on the salt content of the medicine. Uses and effects of the medicine may vary from person to person. It is advisable to consult a Diabetologist before using this medicine.

    Medicines containing Glipizide

    Below is the list of medicines, which contains Glipizide as ingredient

    Information given here is based on the salt content of the medicine. Uses and effects of the medicine may vary from person to person. It is advisable to consult a Diabetologist before using this medicine.

    How does this medication work?

    This medication lowers blood sugar levels by stimulating the production of insulin from pancreatic beta cells. It also regulates the amount of glucose released into the bloodstream.

      Information given here is based on the salt content of the medicine. Uses and effects of the medicine may vary from person to person. It is advisable to consult a Diabetologist before using this medicine.

      What are the interactions of Glipizide ?

      Whenever you take more than one medicine, or mix it with certain foods or beverages, you"re at risk of a drug interaction.

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      • Interaction with Alcohol

        Ethanol

        Consumption of alcohol in large quantities is not recommended when you are taking this medicine for controlling blood sugar levels. It is recommended to reduce the alcohol intake so that the adverse effects can be avoided. Symptoms of both reduced or elevated blood sugar levels should be reported to the doctor immediately.
      • Interaction with Medicine

        Atenolol

        Report the use of any blood pressure medication to the doctor before receiving Glipizide. You may need a more frequent monitoring of blood glucose levels while taking these medicines together.

        Gatifloxacin

        Report the use of either of the medication to the doctor. These medicines should not be used together. Moderate to severe levels of fall in blood sugar have been frequently reported. Sometimes it may also cause an increase in blood sugar levels. Your doctor may prescribe alternatives that do not interact with each other.

        Miconazole

        Report the use of Miconazole or any other antifungal medicine to the doctor. The risks of adverse effects are high when taken together. Your doctor may prescribe an alternate medication that does not interact with Glipizide.

        Ethinyl Estradiol

        Report the use of any hormonal contraceptive to the doctor before receiving this medication. You may need suitable dose adjustments and more frequent monitoring of blood sugar levels while taking these medicines together.

        Selegiline

        Report the use of Selegiline to the doctor before receiving this medication. You may need a dose adjustment and more frequent monitoring of blood glucose levels while taking these medicines together.

        Ibuprofen

        Report the use of Ibuprofen or any other pain medication to the doctor. These medications can cause a fall in blood sugar levels. You may need a dose adjustment and more frequent monitoring of blood sugar levels while taking them together.
      • Interaction with Disease

        Heart Diseases

        This medicine should be administered with extreme caution if you suffer from a disease of heart or blood vessels. Risk of severe to fatal adverse effects is very high in such patients. Both the clinicians and patients should be aware of the risks before deciding the appropriate therapy.

        Diabetic Ketoacidosis

        This medicine should not be used in patients having high acid content in blood as the risk of adverse effects is very high. It applies to both comatose and normal patient with ketoacidosis.

        Kidney Disease

        This medicine should be administered with extreme caution if you suffer from any disease of the kidneys. You should consult your doctor to make a suitable adjustment in dosage quantity and/or time-interval between two dosages.

        Liver Disease

        This medicine should be administered with extreme caution if you suffer from any disease of the liver. You should consult your doctor to make a suitable adjustment in dosage quantity and/or time-interval between two dosages.

        Hypoglycemia

        This medicine should be administered with caution if you are prone to having episodes of low blood sugar. This population includes diabetics who are also malnourished or those receiving Beta-blocker drugs such as Metoprolol and Propranolol.

        Hemolytic Anemia/G6Pd Deficiency

        This medicine is not recommended for use in people suffering from Hemolytic Anemia. Reporting this condition to the doctor is a must. In such cases, alternate medication not belonging to Sulfonylureas should be considered.

      FAQs about Glipizide

      • Ques : What is Glipizide?

        Ans : This is an oral medication for diabetes which helps to keep your blood sugar level in check by stimulating the pancreas to produce more insulin.

      • Ques : How long do I need to use Glipizide before I see improvement in my condition?

        Ans : This medication is to be taken till the time you see an improvement in your health conditions.

      • Ques : At what frequency do I need to use Glipizide?

        Ans : This medication should be taken in the dosage as prescribed by the doctor.

      • Ques : Should I use Glipizide empty stomach, before food or after food?

        Ans : This medication is generally taken 30 minutes before a meal.

      • Ques : What are the instructions for the storage and disposal of Glipizide?

        Ans : This medication should be kept in a cool dry place and in its original packaging. Make sure this medication remains unreachable to children and pets.

      References

      • Glipizide- Drug Information Portal [Internet]. druginfo.nlm.nih.gov. 2019 [Cited 17 December 2019]. Available from:

        https://druginfo.nlm.nih.gov/drugportal/name/glipizide

      • Glipizide- DrugBank [Internet]. Drugbank.ca. 2017 [Cited 17 December 2019]. Available from:

        https://www.drugbank.ca/drugs/DB01067

      • Glipizide 5 mg Tablets- EMC [Internet] medicines.org.uk. 2017 [Cited 17 December 2019]. Available from:

        https://www.medicines.org.uk/emc/product/8543/smpc

      Disclaimer : The information produced here is best of our knowledge and experience and we have tried our best to make it as accurate and up-to-date as possible, but we would like to request that it should not be treated as a substitute for professional advice, diagnosis or treatment.

      Lybrate is a medium to provide our audience with the common information on medicines and does not guarantee its accuracy or exhaustiveness. Even if there is no mention of a warning for any drug or combination, it never means that we are claiming that the drug or combination is safe for consumption without any proper consultation with an expert.

      Lybrate does not take responsibility for any aspect of medicines or treatments. If you have any doubts about your medication, we strongly recommend you to see a doctor immediately.
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      Written ByDrx Hina FirdousPhD (Pharmacology) Pursuing, M.Pharma (Pharmacology), B.Pharma - Certificate in Nutrition and Child CarePharmacology
      Reviewed By
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      Reviewed ByDr. Garima SharmaMBBS, Master in Healthcare Administration, Diploma in Occupational HealthGeneral Physician
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