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Clomifene is a non-steroidal, ovulatory stimulant. It acts as a selective oestrogen receptor modulator. It is a medication used to treat infertility in women and help them get pregnant. It is meant for those women who do not ovulate. This includes those who have polycystic ovary syndrome. Its long term use results in multiple ovulation and increases chance of twins. It is taken by mouth once a day.

Side-effects of this medicine tend to be mild, but you should speak with your doctor as soon as possible if you are feeling flushed, feeling sick, experience a headache, breast discomfort, painful periods, weight gain, bleeding between periods, feeling bloated, abdominal discomfort, eyesight problems such as blurred vision, or flashes, or spots in front of your eyes.

Clomifene is not suitable for people with certain conditions, and may only be used if extra care is taken. For these reasons, before you start taking this medicine, inform your doctor if you are or have:

  • Lliver disorders.
  • Ovarian cysts or uterine fibroids
  • Hormone-dependent tumour.
  • Heavy or unusual menstrual flow.
  • Taking any other medicines including the ones without a prescription, such as herbal and complementary medicines.
  • An allergic reaction to a medicine.

Clomifene is taken in treatment cycles of five days - this means that you will take one dose daily for five days of the month. For the first course, you are recommended to take one 50 mg tablet daily for five days. Your dose may be increased to two tablets daily on subsequent courses if your doctor thinks this is necessary. Take regular appointments with your doctor to keep your progress on check.

Information given here is based on the salt content of the medicine. Uses and effects of the medicine may vary from person to person. It is advisable to consult a Internal Medicine Specialist before using this medicine.

This medicine is primarily used to treat:

  • Infertility Due To Ovulatory Failure

    This medicine is used for the treatment of infertility caused due to failure of the ovary to release an egg after other reasons for the infertility is ruled out.

These are the following side effects of this medication:

  • Flushing

  • Nausea Or Vomiting

  • Headache

  • Abnormal Vaginal Bleeding

  • Blurred Vision

  • Hot Flashes

  • Difficulty In Breathing

  • Severe Stomach Ache

  • Weight Gain

  • Yellow Colored Eyes Or Skin

  • Anxiety And Nervousness

  • Breast Pain

  • Trouble Sleeping

  • How long is the duration of effect?

    The effect of this medicine lasts for an average duration of 15-20 days.
  • What is the onset of action?

    The effect of this medicine can be observed after 5-10 days of administration.
  • Are there any pregnancy warnings?

    Use of this medicine is not recommended for women who are pregnant. Any suspicion of a pregnancy should be ruled out before starting the use of this medicine. It is advised to consult your doctor and discuss the benefits and risks before deciding to take this medicine.
  • Is it habit forming?

    No habit forming tendencies were reported.
  • Are there any breast-feeding warnings?

    Use of this women is not recommended for women who are breastfeeding. If the use of this medicine is absolutely necessary then your doctor may ask to discontinue breastfeeding.
  • Is It safe with alcohol?

    Caution is advised while consuming alcohol with Clomifene. Kindly consult your doctor.
  • Is it safe to drive while on this medicine?

    This medicine affect the vision (blurred vision) of the patient for a short duration of time just after its use. Do not drive until the vision become clear.
  • Does this affect kidney function?

    Limited information is available on using Clomifene in patients with kidney disease. Kindly consult your doctor before taking this medicine.
  • Does this affect liver function?

    Clomifene is probably unsafe to use in the patients with liver disease and should be avoided. Kindly consult your doctor.
  • Missed Dose instructions

    Call the doctor for further instructions if you miss a scheduled dose of this medicine.
  • Overdose instructions

    Contact a doctor immediately if an overdose with this medicine is suspected. Symptoms may include nausea, vomiting, headache, hot flashes etc.
  • India

  • United States

  • Japan

Below is the list of medicines, which contains Clomifene as ingredient

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This medication works on the pituitary gland and induces the release of hormones required for the release of an egg from the ovary.

Whenever you take more than one medicine, or mix it with certain foods or beverages, you"re at risk of a drug interaction.

  • Interaction with Alcohol

    Interaction with alcohol is unknown. It is advisable to consult your doctor before consumption.
  • Interaction with Lab Test

    Information not available.
  • Interaction with Medicine


    Report the use of either of the medicine to the doctor. You may need a dose adjustment and frequent clinical monitoring to safely use these medicines together.
  • Interaction with Food

    Information not available.
  • Interaction with Disease

    Information not available.

Ques: What is Clomifene?

Ans: Clomifene is a salt which performs its action by promoting the release of reproductive hormones. This helps stimulate the release of eggs from the ovary (ovulation).

Ques: What are the uses of Clomifene?

Ans: Clomifene is used for the treatment and prevention from conditions such as Infertility due to ovulatory failure.

Ques: What are the Side Effects of Clomifene?

Ans: Clomifene is a medication which has some commonly reported side effects. These side effects may or may not occur always and some of them are rare but severe. Some side effects of Clomifene are Flushing, Nausea or Vomiting, Headache, Abnormal vaginal bleeding, Blurred vision, Hot flashes, Difficulty in breathing, Severe stomach ache, Weight gain, Yellowing of skin and eyes, Anxiety and nervousness, Breast pain and tenderness, and Trouble sleeping.

Ques: What are the instructions for storage and disposal Clomifene?

Ans: Clomifene should be kept in a cool dry place and in its original pack. Make sure this medication remains unreachable to children and pets.

Ques: Should I use Clomifene empty stomach, before food or after food?

Ans: This medication is supposed to be taken after having food. If you take it on an empty stomach, it might upset your stomach. Please consult the doctor before using Clomifene.

Ques: How long do I need to use Clomifene before I see improvement of my conditions?

Ans: This medication will take around 5 to 10 days of a time range to improve patients' condition. The time will vary according to the severity of the condition. It is advised to follow the time period directed by your doctor to use Clomifene.

Ques: Is there any food or drink I need to avoid?

Ans: There is no specific food product to avoid, under usage of this medication. It will be beneficial to keep your diet healthy and to ignore street food. It is also advised to stay away from drinking alcohol and smoking.

Ques: Will Clomifene be more effective if taken in more than the recommended dose?

Ans: Please follow the doses of the medication, as prescribed by your doctor. If you take more than the recommended doses of Clomifene, it may cause some side effects.

Ques: After how many days of Clomifene intake should I have sex to get pregnant?

Ans: It is advised to have sexual intercourse after about a week of taking this medicine if you wish to get pregnant. Doctor consultation is suggested.

Ques: For how many cycles can I take Clomifene?

Ans: You should take this drug until you get pregnant. However, the medicine in general should be used only upto four cycles.

Ques: Can I take Clomifene without a doctor’s prescription?

Ans: It is not an OTC drug, hence prescription is required. Do not take this medication without consulting a doctor.

Ques: Can I take Clomifene if I have an ovarian cyst?

Ans: It is suggested to avoid taking this medicine if you have a cyst as it can interfere negatively.

Ques: Can I take Clomifene with metformin?

Ans: This drug can be taken with metformin only after consulting a doctor.
Disclaimer: The information produced here is best of our knowledge and experience and we have tried our best to make it as accurate and up-to-date as possible, but we would like to request that it should not be treated as a substitute for professional advice, diagnosis or treatment.

Lybrate is a medium to provide our audience with the common information on medicines and does not guarantee its accuracy or exhaustiveness. Even if there is no mention of a warning for any drug or combination, it never means that we are claiming that the drug or combination is safe for consumption without any proper consultation with an expert.

Lybrate does not take responsibility for any aspect of medicines or treatments. If you have any doubts about your medication, we strongly recommend you to see a doctor immediately.

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Table of Content
About Clomifene
What are the uses of Clomifene
What are the contraindications of Clomifene ?
What are the side effects of Clomifene ?
Key highlights of Clomifene
What are the dosage instructions?
Where is the Clomifene approved?
Medicines containing Clomifene
How does this medication work?
What are the interactions of Clomifene ?
FAQs about Clomifene