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Prescription vs.OTC: Prescription by Doctor required
Last Updated: July 19, 2019

Clomifene is a non-steroidal, ovulatory stimulant. It acts as a selective oestrogen receptor modulator. It is a medication used to treat infertility in women and help them get pregnant. It is meant for those women who do not ovulate. This includes those who have polycystic ovary syndrome. Its long term use results in multiple ovulation and increases chance of twins. It is taken by mouth once a day.

Side-effects of this medicine tend to be mild, but you should speak with your doctor as soon as possible if you are feeling flushed, feeling sick, experience a headache, breast discomfort, painful periods, weight gain, bleeding between periods, feeling bloated, abdominal discomfort, eyesight problems such as blurred vision, or flashes, or spots in front of your eyes.

Clomifene is not suitable for people with certain conditions, and may only be used if extra care is taken. For these reasons, before you start taking this medicine, inform your doctor if you :

  • have liver disorders.
  • have ovarian cysts or uterine fibroids
  • have a hormone-dependent tumour.
  • have heavy or unusual menstrual flow.
  • are taking any other medicines including the ones without a prescription, such as herbal and complementary medicines.
  • have ever had an allergic reaction to a medicine.

Clomifene is taken in treatment cycles of five days - this means that you will take one dose daily for five days of the month. For the first course, you are recommended to take one 50 mg tablet daily for five days. Your dose may be increased to two tablets daily on subsequent courses if your doctor thinks this is necessary. Take regular appointments with your doctor to keep your progress on check.

Information given here is based on the salt and content of the medicine. Effect and uses of medicine may vary from person to person. It is advicable to consult a Internal Medicine Specialist before using this medicine.

  • Infertility due to ovulatory failure

    This medicine is used for the treatment of infertility caused due to failure of the ovary to release an egg after other reasons for the infertility is ruled out.
  • Allergy

    This medicine is not recommended for use if you have a known history of allergy to Clomifene or any other component present with it.
  • Undiagnosed vaginal bleeding

    This medicine is not recommended for use if you have abnormal vaginal/uterine bleeding that is yet to be diagnosed.
  • Thyroid/Adrenal gland disorder

    This medicine is not recommended for use in patients having an active disease of the thyroid or adrenal glands.
  • Endometrial cancer

    This medicine is not recommended for use in patients having uterine cancer.
  • Liver disease

    This medicine is not recommended for use in patients having an impairment of liver function.
  • Flushing

  • Nausea or Vomiting

  • Headache

  • Abnormal vaginal bleeding

  • Blurred vision

  • Hot flashes

  • Difficulty in breathing

  • Severe stomach ache

  • Weight gain

  • Yellowing of skin and eyes

  • Anxiety and nervousness

  • Breast pain and tenderness

  • Trouble sleeping

  • How long is the duration of effect?

    The effect of this medicine lasts for an average duration of 15-20 days.
  • What is the onset of action?

    The effect of this medicine can be observed after 5-10 days of administration.
  • Are there any pregnancy warnings?

    Use of this medicine is not recommended for women who are pregnant. Any suspicion of a pregnancy should be ruled out before starting the use of this medicine. It is advised to consult your doctor and discuss the benefits and risks before deciding to take this medicine.
  • Is it habit forming?

    No habit forming tendencies were reported.
  • Are there any breast-feeding warnings?

    Use of this women is not recommended for women who are breastfeeding. If the use of this medicine is absolutely necessary then your doctor may ask to discontinue breastfeeding.
  • Missed Dose instructions

    Call the doctor for further instructions if you miss a scheduled dose of this medicine.
  • Overdose instructions

    Contact a doctor immediately if an overdose with this medicine is suspected. Symptoms may include nausea, vomiting, headache, hot flashes etc.
  • India

  • United States

  • Japan

Below is the list of medicines, which contains Clomifene as ingredient

Clomifene works on the pituitary glands and induces the release of hormones required for the release of an egg from the ovary.

Whenever you take more than one medicine, or mix it with certain foods or beverages, you"re at risk of a drug interaction.

  • Interaction with Disease


    Information not available.
  • Interaction with Alcohol


    Interaction with alcohol is unknown. It is advisable to consult your doctor before consumption.
  • Interaction with Lab Test


    Information not available.
  • Interaction with Food


    Information not available.
  • Interaction with Medicine


    Report the use of either of the medicine to the doctor. You may need a dose adjustment and frequent clinical monitoring to safely use these medicines together.

Ques: What is Clomifene?

Ans: Clomifene is a salt which performs its action by promoting the release of reproductive hormones. This helps stimulate the release of eggs from the ovary (ovulation). Clomifene is used to treat conditions such as Infertility due to ovulatory failure.

Ques: What are the uses of Clomifene?

Ans: Clomifene is a medication, which is used for the treatment and prevention from conditions such as Infertility due to ovulatory failure. The patient should inform the doctor about any ongoing medications and treatment before using Clomifene to avoid undesirable effects.

Ques: What are the Side Effects of Clomifene?

Ans: Clomifene is a medication which has some commonly reported side effects. These side effects may or may not occur always and some of them are rare but severe. This is not a complete list and if you experience any of the below-mentioned side effects, contact your doctor immediately. Here are some side effects of Clomifene which are as follows: Flushing, Nausea or Vomiting, Headache, Abnormal vaginal bleeding, Blurred vision, Hot flashes, Difficulty in breathing, Severe stomach ache, Weight gain, Yellowing of skin and eyes, Anxiety and nervousness, Breast pain and tenderness, and Trouble sleeping. It is a list of possible side-effects which may occur due to the constituting ingredients of Clomifene.

Ques: What are the instructions for storage and disposal Clomifene?

Ans: Clomifene should be kept in a cool dry place and in its original pack. Make sure this medication remains unreachable to children and pets. The patient should consult a doctor for its further uses and side effects and should inform the doctor about any ongoing medications and treatment before using to avoid undesirable effects. It is a prescribed medication.

Ques: Should I use Clomifene empty stomach, before food or after food?

Ans: This medication is to be consumed orally. The salts involved in this medication react properly if it is taken after having food. If you take it on an empty stomach, it might upset your stomach. Please consult the doctor before using Clomifene.

Ques: How long do I need to use Clomifene before I see improvement of my conditions?

Ans: This medication will take around 5 to 10 days of a time range to improve patients condition. The time will vary according to the severity of the condition. It is advised to follow the time period directed by your doctor to use Clomifene.

Ques: Is there any food or drink I need to avoid?

Ans: There is no specific food product to avoid, under usage of this medication. It will be beneficial to keep your diet healthy and to ignore street food in order to avoid any kind of harmful bacterial intake. It is also advised to stay away from drinking and smoking to uplift your health.

Ques: Will Clomifene be more effective if taken in more than the recommended dose?

Ans: Please follow the doses of the medication, as prescribed by your doctor. If you take more than the recommended doses of Clomifene, it may cause some side effects. It is advised to ask your doctor to re-examine your condition if the severity in the health is not reducing.
Disclaimer: The information produced here is best of our knowledge and experience and we have tried our best to make it as accurate and up-to-date as possible, but we would like to request that it should not be treated as a substitute for professional advice, diagnosis or treatment.

Lybrate is a medium to provide our audience with the common information on medicines and does not guarantee its accuracy or exhaustiveness. Even if there is no mention of a warning for any drug or combination, it never means that we are claiming that the drug or combination is safe for consumption without any proper consultation with an expert.

Lybrate does not take responsibility for any aspect of medicines or treatments. If you have any doubts about your medication, we strongly recommend you to see a doctor immediately.

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Table of Content
About Clomifene
What are the uses of Clomifene
What are the contraindications of Clomifene ?
What are the side effects of Clomifene ?
Key highlights of Clomifene
What are the dosage instructions?
Where is the Clomifene approved?
Medicines containing Clomifene
How does medicine works?
What are the interactions of Clomifene ?
Clomifene Frequently Asked Questions (FAQs):