Aprotinin

Aprotinin, also known as bovine pancreatic trypsin inhibitor, BPTI (Trasylol, Bayer). It is a protein, that is used as medication administered by injection to reduce bleeding during complex surgery, such as heart and liver surgery. Its main effect is the slowing down of fibrinolysis, the process that leads to the breakdown of blood clots.

The aim in its use is to decrease the need for blood transfusions during surgery, as well as end-organ damage due to hypotension (low blood pressure) as a result of marked blood loss. Aprotinin is used in the treatment of Hemorrhage and prevention of Blood Loss, Surgical.

The loading dose should be given intravenously to patients in the supine position over a 20-30 minute period. Rapid intravenous administration can cause a transient fall in blood pressure. Pediatric use is not recommended. Patient may develop with increased risk of severe allergic reactions if it is administered within 12 months of previous use of this medication.

Information given here is based on the salt content of the medicine. Uses and effects of the medicine may vary from person to person. It is advisable to consult a Hematologist before using this medicine.

• Bleeding

Information given here is based on the salt content of the medicine. Uses and effects of the medicine may vary from person to person. It is advisable to consult a Hematologist before using this medicine.

• Hypersensitivity

Information given here is based on the salt content of the medicine. Uses and effects of the medicine may vary from person to person. It is advisable to consult a Hematologist before using this medicine.

• Atrial Fibrillation

• Acute myocardial infarction

• Heart Failure

• Supraventricular Tachycardia

• Hypotension

• Fever

• Renal Dysfunction

• Liver Damage

Information given here is based on the salt content of the medicine. Uses and effects of the medicine may vary from person to person. It is advisable to consult a Hematologist before using this medicine.

• Is It safe with alcohol?

  Interaction with alcohol is unknown. Please consult your doctor.

• Are there any pregnancy warnings?

  This drug should not be consumed during pregnancy unless necessary. Consulting a doctor is mandatory to discuss the benefits and risks before taking the medicine.

• Are there any breast-feeding warnings?

  This drug can be given to the women who are breastfeeding but only after evaluating the benefits and risks with the doctor.

• Is it safe to drive while on this medicine?

  Not relevant, as this drug is intended for use in hospitalised patients.

• Does this affect kidney function?

  There is limited information available on the use of this drug in patients with kidney disease. Please consult your doctor.

• Does this affect liver function?

  There is no data available. Please consult doctor before consuming the drug.

• How long is the duration of effect?

  The duration of effect of this medication is about 150 minutes.

• What is the onset of action?

  Information not available.

Information given here is based on the salt content of the medicine. Uses and effects of the medicine may vary from person to person. It is advisable to consult a Hematologist before using this medicine.

• Are there any overdose instructions?

  Seek emergency medical treatment or contact the doctor in case of an overdose.

• Are there any missed dose instructions?

  If you miss a dose of this medicine, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular schedule. Do not double the dose.

Information given here is based on the salt content of the medicine. Uses and effects of the medicine may vary from person to person. It is advisable to consult a Hematologist before using this medicine.

Below is the list of medicines, which contains Aprotinin as ingredient

• Reliseal Kit

  Reliance Formulation Pvt Ltd

Information given here is based on the salt content of the medicine. Uses and effects of the medicine may vary from person to person. It is advisable to consult a Hematologist before using this medicine.

This medication belongs to the class of a protease inhibitor which acts as a coagulating agent by inhibiting several serine proteases. Inhibition of these proteases activates signalling pathways that inhibit fibrinolysis or breakdown of blood clots, resulting in reduced bleeding.

Information given here is based on the salt content of the medicine. Uses and effects of the medicine may vary from person to person. It is advisable to consult a Hematologist before using this medicine.

Whenever you take more than one medicine, or mix it with certain foods or beverages, you"re at risk of a drug interaction.

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• Interaction with Medicine

  This drug interacts with Heparin and aprotinin prolong ACT, Fibrinolytic drugs, and Captopril's antihypertensive.

• Ques : What is Aprotinin?

  Ans : This drug is known as bovine pancreatic trypsin inhibitor, BPTI (Trasylol, Bayer). It is a protein, that is used as medication administered by injection to reduce bleeding during complex surgery, such as heart and liver surgery.

• Ques : How long do I need to use Aprotinin before I see improvement in my condition?

  Ans : This medication should be consumed, until the complete eradication of the disease. Thus it is advised to use, till the time directed by your doctor. Also taking this medication longer than it was prescribed, can cause an inadequate effect on the patient's condition.

• Ques : At what frequency do I need to use Aprotinin?

  Ans : The duration of effect for this medicine is dependent on the severity of the patient’s condition. Therefore the frequency of usage of this medication will vary from person to person. It is advised to follow the proper prescription of the doctor, directed according to the patient's condition.

• Ques : Should I use Aprotinin empty stomach, before food or after food?

  Ans : This medication is advised to be consumed orally. The salts involved in this medication react properly if it is taken after having food. If you take it on an empty stomach, it might upset the stomach. Please consult the doctor before using it.

• Ques : What are the instructions for the storage and disposal of Aprotinin?

  Ans : This medication contains salts which are suitable to store only at room temperature, as keeping this medication above or below that, can cause an inadequate effect. Protect it from moisture and light. Keep this medication away from the reach of children.