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Hodgkin lymphoma: Causes, Symptoms, Risk Factors and Treatment

MBBS, DNB Radiation Oncology, Fellowship in Radiation Oncology
Oncologist, Mumbai
Hodgkin lymphoma: Causes, Symptoms, Risk Factors and Treatment




Immune system in the body is also made by a system called the lymphatic system. This system fights with germ near tissue in the body and also it penetrates deep to defend the body. A certain type of cancer called hodgkin lymphoma affects the whole lymphatic system. ;

When hodgkin lymphoma happens to the body the lymphocytes also known as white blood cells increase in number so excessively like a cancer growth. This increase in number causes the lymph nodes to swell all over the body and there are many other growth all over the body due to it.

There are two types of lymphoma called hodgkin lymphoma and non-hodgkin lymphoma. Hodgkin lymphoma is known by another name called hodgkin's disease.

Medical advances in diagnosis and treatment and medicines have helped the people to recover fully from this hodgkin disease. Some who do not recover fully show promising progress.

Symptoms:

There are some signs and symptoms of hodgkin's lymphoma:



There is swelling of the lymph nodes found in the neck, armpits, groin. This swelling is painless.


The body will feel tired all the time.


There will be a fever.


There will be night sweats while sleeping.


There will be weight loss.


There will be itching in the body.


When you drink alcohol, pain starts in the lymph nodes.



When to see a doctor:

When you find any symptoms in the body as given below you must rush to the doctor for this is a very serious disease. The following symptoms are:



There is swelling of the lymph nodes found in the neck, armpits, groin. This swelling is painless.


The body will feel tired all the time.


There will be a fever.


There will be night sweats while sleeping.


There will be weight loss.


There will be itching in the body.


When you drink alcohol, pain starts in the lymph nodes.



Causes:

After much research, researchers and doctors do not know the cause of hodgkin lymphoma. There is only some information like lymphoma begins only when these defense cells, white blood cells develop any change in their dna. This dna tells them to increase their number and cause other problems. It feels like some infection or germs or virus have infected the white blood cell for their control.

The dna contains the instructions for all cells and each cell has their own dna. Infected dna tells the white blood cells to multiply and increase in number as well as to not to die like other normal cells do. As white blood cells are the part of the immune system, it has got a defense from other healthy defensive cells in the body. This defense protects the mutated white blood cells and helps them to grow in number. When there is a high number of cells they crowd at the storage of defense cells that are at lymph nodes and make them swell and behave in healthy ways.

There are many types of hodgkin lymphoma. Each type has its own characteristics because each cell with different mutations gives different behavior. These different types have characteristics that determine the type of treatment should be given.

The most common nowadays is the classical hodgkin's lymphoma. People who suffer from this on analyzing their nodes researchers find out that this type of lymphoma have very large white blood cells in their nodes called reed-sternberg cells. There are subtypes of this classical hodgkin's lymphoma. Their names are:



Nodular sclerosis- hodgkin's lymphoma


Mixed cellularity- hodgkin's lymphoma


Lymphocyte-depleted hodgkin's lymphoma


Lymphocyte-rich hodgkin's lymphoma



Nodular lymphocyte-predominant hodgkin's lymphoma is the rare type of hodgkin lymphoma. In this lymphoma white blood cells look like popcorn and white blood cells are called popcorn cells in this lymphoma due to their appearance. This is usually at an early stage for a long time and easily diagnosed. This also requires less intensive treatment. ;

Risk factors:

There are some factors which can trigger the occurrence of hodgkin lymphoma. Such factor are:



Your age: hodgkin's lymphoma always occurs to people who are aged 20 to 30 years or people at 60 years.


A family chart of lymphoma: if your family members had hodgkin's lymphoma, your coming generation may have this lymphoma at their 60 years. So we should check it at the early years of our child or relative.


Being male: females are protected against this lymphoma somehow but male are not because they are more likely to have lymphoma.


Past epstein-barr infection: epstein-barr virus causes people to have illnesses such as infectious mononucleosis. People who have suffered from this virus are more likely to have hodgkin lymphoma than people who do have epstein-barr virus infections. ;


Hiv infection: these patients have a failed immune system, which increases the risk of hodgkin's lymphoma.





Treatment:

People with hodgkin lymphoma are given chemotherapy, radiation therapy, or when needed bone marrow transplant. There are many drugs which are given to control the birth rate of lymphocytes.

Conclusion:

Hodgkin lymphoma is rare but people are there who suffer from this. Treatment can cause them to have full recovery. But people can avoid it by having many fruits which are able to prevent cancer. For more information please visit the doctor.
1 person found this helpful

My nephew 8 years nephew was diagnosed with acute lymphoblastic leukemia and was admitted to the local cancer clinic, upon addition, he's hb was 1 and he's rbcs was 2.5. They did multiple blood transfusions and managed to elevate the hb and rbc count. Can I recommend stem cell treatment to my nephew?

Bachelor of Ayurveda, Medicine and Surgery (BAMS)
Ayurvedic Doctor, Zirakpur
Doctor at center is the best guide. I would suggest even if you go for it, do not ignore fo give erythropoetic and anti karkat herbals to raise natural immunity and prevent failures of modern techniques. No harm. We respect every system of medicine. These are complimentary to each other. Pl consult once in your own interest or talk by booking on Lybrate.
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My mother had cml and is taking imatinib 400 mg once day since last 4 years .today her cbc was done where tlc count was only 1800 I am so worried please help and suggest why it has hand and what has to be done. Is it anything to worry about.

MBBS Bachelor of Medicine and Bachelor of Surgery, MD - Paediatrics, PDCC Hemato-oncology
Hematologist, Delhi
This may be due to medicine effect or due to disease progression both. Need to withhold imatinib and get bcr-abl pcr done, if this report shows a high percentage value, medicine to be changed, if not detected, imatinib dosage needs reduction further.
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Can mri of head and neck diagnose or give some clues about lymphoma. Please suggest.

MBBS, Basic Life Support (B.L.S), Advanced Cardiac Life Support, Fellow of Academy of General Education (FAGE)
General Physician, Delhi
I am sorry to hear about your concern but will be happy to assist you. An mri scan is helpful in detecting lymphoma that has spread to the spinal cord or brain. It can be helpful in other areas of the body as well, such as the head and neck area. Abdominal ultrasound: abdominal ultrasound may be used to examine enlarged lymph nodes, especially in the abdomen. Let's connect over a call so that we can discuss your concern in details and make a suitable treatment plan for you.
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I have dlc lymphocyte count of 44, with normal tlc and absolute lymphocyte count, meaning I have relative lymphocytosis. And I also have itching over body. Is it lymphoma? I took hgh 2 iu daily for 45 days for increasing my athletic performance.

MBBS, Basic Life Support (B.L.S), Advanced Cardiac Life Support, Fellow of Academy of General Education (FAGE)
General Physician, Delhi
I am sorry to hear about your concern but will be happy to assist you. The normal range for lymphocytes is between 800 and 5000 (0.8-5.0) lymphocytes per ml of blood. A normal lymphocytes percentage is 18-45% of total white blood cells. Let's connect over a call so that we can discuss your concern in details and make a suitable treatment plan for you.
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Dear sir, for diagnosing lymphoma, which test is accurate mri scan or biopsy. Please suggest.

MBBS, Basic Life Support (B.L.S), Advanced Cardiac Life Support, Fellow of Academy of General Education (FAGE)
General Physician, Delhi
I am sorry to hear about your concern but will be happy to assist you a lymph node biopsy is the gold standard for diagnosing lymphoma. Often, it's the only test that can provide an official diagnosis. During the procedure, a specialist takes a sample of a lymph node. The sample is examined under a microscope for signs of lymphoma. Let's connect over a call so that we can discuss your concern in details and make a suitable treatment plan for you.
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My wife have lymphoma so I want to asked you she have 1 lean in right side breast so can it be treatable with chimo therapy our it better to opret it.

MBBS, Basic Life Support (B.L.S), Advanced Cardiac Life Support, Fellow of Academy of General Education (FAGE)
General Physician, Delhi
Lymphoma can develop when lymphocytes white blood cells that fight infection grow out of control. This is caused by genetic changes in the cells. Let's have a detailed discussion for better advice and medication plan.
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Hello Doctor, Biopsy results shows reactive changes in lymph nodes. Microscopic results shows lymphoid follicles of variable sizes of prominent germinal centers with tangible body macrophages.

MBBS, Basic Life Support (B.L.S), Advanced Cardiac Life Support, Fellow of Academy of General Education (FAGE)
General Physician, Delhi
Hello Doctor, Biopsy results shows reactive changes in lymph nodes. Microscopic results shows lymphoid follicles of v...
Biopsy of a mass, you might also see a reference to reactive lymph nodes when you review your lab results. This means your lymph nodes are reacting to something going on in your body. However, it's usually not a reaction to anything serious. In fact, most of the time, reactive lymph nodes are harmless. But we have to look into the details of the problem. Let's have a detailed discussion for better advice and healthy lifestyle.
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Non-Hodgkin Lymphoma - What Are The Risk Factors Of It?

MBBS, MS - General Surgery, DNB - Surgical Oncology
Oncologist, Lucknow
Non-Hodgkin Lymphoma - What Are The Risk Factors Of It?
Non Hodgkin Lymphoma is when the cells in your lymphatic system become cancerous. The lymphatic system is responsible for fighting off diseases which may attack your body. Initially, tumors develop from the lymphocytes in your body. Non-Hodgkin lymphoma is much more common than the other type of lymphoma which is Hodgkin lymphoma. There are various types of Non-Hodgkin lymphoma; the most common of which are diffuse large B-cell lymphoma and follicular lymphoma. Here is everything you need to know about Non-Hodgkin lymphoma.

Symptoms

1. Swollen lymph nodes
A swollen lymph node in the neck, underarm and armpit which comes about without any pain is a very common symptom of non-Hodgkin lymphoma.

2. Fever
When you have a sudden unexplained fever, it may be due to Non-Hodgkin lymphoma.

3. Night sweats
Night sweats are simply when you sweat excessively in the night.

4. Fatigue
Feeling extremely tired can be due to Non-Hodgkin lymphoma.

5. Weight loss
A sudden unexplained loss of weight is a very common symptom of non-Hodgkin lymphoma.

6. Itchiness
An itchy skin is a rather serious indicator of Non-Hodgkin lymphoma.

Causes

Just like other forms of cancer, it is not known what causes Non-Hodgkin lymphoma but there are factors which put you more at risk compared to others.

Risk factors

1. Immunosuppressive drugs
You are more likely to develop Non-Hodgkin lymphoma especially after taking immunosuppressive drugs after a major organ transplant.

2. Bacteria and viruses
Certain bacterial and viral infections cause Non-Hodgkin lymphoma including the HIV and Epstein-Barr virus as well as the Helicobacter pylori bacteria.

3. Pesticides
Research suggests that overexposure to the pesticides which kill weeds increases your likelihood of developing Non-Hodgkin lymphoma.

4. Age
Elder people are also more likely to suffer from Non-Hodgkin lymphoma.

Treatment

1. Chemotherapy
Chemotherapy comprises of administering drugs to kill the cancerous cells, either through injection or orally which kill cancer.

2. Radiation therapy
Radiation therapy deals with radiation which is directed at the parts of your body affected by cancer.

3. Medications to enhance the immune system
There are many medications which fight off cancer by boosting the immune system.
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I have pain in the right arm since last two weeks I visited ortho doctor he said lymphoma in the arm he doubts, Is it early stage cancer? He advises me to take the mri scan. Please suggest to me.

C.S.C, D.C.H, M.B.B.S
General Physician, Alappuzha
Your pain is arthritic pain and not cancer and it is safe to do an mri as it will clear any doubts.
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