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Hodgkin lymphoma: Causes, Symptoms, Risk Factors and Treatment

MBBS, DNB Radiation Oncology, Fellowship in Radiation Oncology
Oncologist, Mumbai
Hodgkin lymphoma: Causes, Symptoms, Risk Factors and Treatment




Immune system in the body is also made by a system called the lymphatic system. This system fights with germ near tissue in the body and also it penetrates deep to defend the body. A certain type of cancer called hodgkin lymphoma affects the whole lymphatic system. ;

When hodgkin lymphoma happens to the body the lymphocytes also known as white blood cells increase in number so excessively like a cancer growth. This increase in number causes the lymph nodes to swell all over the body and there are many other growth all over the body due to it.

There are two types of lymphoma called hodgkin lymphoma and non-hodgkin lymphoma. Hodgkin lymphoma is known by another name called hodgkin's disease.

Medical advances in diagnosis and treatment and medicines have helped the people to recover fully from this hodgkin disease. Some who do not recover fully show promising progress.

Symptoms:

There are some signs and symptoms of hodgkin's lymphoma:



There is swelling of the lymph nodes found in the neck, armpits, groin. This swelling is painless.


The body will feel tired all the time.


There will be a fever.


There will be night sweats while sleeping.


There will be weight loss.


There will be itching in the body.


When you drink alcohol, pain starts in the lymph nodes.



When to see a doctor:

When you find any symptoms in the body as given below you must rush to the doctor for this is a very serious disease. The following symptoms are:



There is swelling of the lymph nodes found in the neck, armpits, groin. This swelling is painless.


The body will feel tired all the time.


There will be a fever.


There will be night sweats while sleeping.


There will be weight loss.


There will be itching in the body.


When you drink alcohol, pain starts in the lymph nodes.



Causes:

After much research, researchers and doctors do not know the cause of hodgkin lymphoma. There is only some information like lymphoma begins only when these defense cells, white blood cells develop any change in their dna. This dna tells them to increase their number and cause other problems. It feels like some infection or germs or virus have infected the white blood cell for their control.

The dna contains the instructions for all cells and each cell has their own dna. Infected dna tells the white blood cells to multiply and increase in number as well as to not to die like other normal cells do. As white blood cells are the part of the immune system, it has got a defense from other healthy defensive cells in the body. This defense protects the mutated white blood cells and helps them to grow in number. When there is a high number of cells they crowd at the storage of defense cells that are at lymph nodes and make them swell and behave in healthy ways.

There are many types of hodgkin lymphoma. Each type has its own characteristics because each cell with different mutations gives different behavior. These different types have characteristics that determine the type of treatment should be given.

The most common nowadays is the classical hodgkin's lymphoma. People who suffer from this on analyzing their nodes researchers find out that this type of lymphoma have very large white blood cells in their nodes called reed-sternberg cells. There are subtypes of this classical hodgkin's lymphoma. Their names are:



Nodular sclerosis- hodgkin's lymphoma


Mixed cellularity- hodgkin's lymphoma


Lymphocyte-depleted hodgkin's lymphoma


Lymphocyte-rich hodgkin's lymphoma



Nodular lymphocyte-predominant hodgkin's lymphoma is the rare type of hodgkin lymphoma. In this lymphoma white blood cells look like popcorn and white blood cells are called popcorn cells in this lymphoma due to their appearance. This is usually at an early stage for a long time and easily diagnosed. This also requires less intensive treatment. ;

Risk factors:

There are some factors which can trigger the occurrence of hodgkin lymphoma. Such factor are:



Your age: hodgkin's lymphoma always occurs to people who are aged 20 to 30 years or people at 60 years.


A family chart of lymphoma: if your family members had hodgkin's lymphoma, your coming generation may have this lymphoma at their 60 years. So we should check it at the early years of our child or relative.


Being male: females are protected against this lymphoma somehow but male are not because they are more likely to have lymphoma.


Past epstein-barr infection: epstein-barr virus causes people to have illnesses such as infectious mononucleosis. People who have suffered from this virus are more likely to have hodgkin lymphoma than people who do have epstein-barr virus infections. ;


Hiv infection: these patients have a failed immune system, which increases the risk of hodgkin's lymphoma.





Treatment:

People with hodgkin lymphoma are given chemotherapy, radiation therapy, or when needed bone marrow transplant. There are many drugs which are given to control the birth rate of lymphocytes.

Conclusion:

Hodgkin lymphoma is rare but people are there who suffer from this. Treatment can cause them to have full recovery. But people can avoid it by having many fruits which are able to prevent cancer. For more information please visit the doctor.
1 person found this helpful

My wife is suffering from blood cancer type aml-relapse. As per today cbc hb7, tlc 0.77 and platelets 31 and on 10.02.22, hb8, tlc 0.9 and platelets 10 now from morning she has fever and now fever is 100.4, paracetamol 650, vericoat, ceftum given but not relief. Any oncologist please reply. I want to avoid hospitalization.

MBBS, MD - Paediatrics, Fellowship - Hematology & Oncology, Renzo Gallanelo Fellowship
Hematologist, Ludhiana
As TLC is very low, she should be admitted as fever in this case is a medical emergency. I understand you are in a very tough position. What have you decided for her treatment. Are you planning to go for 2nd line therapy or not.
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My mother suffering from blood cancer c.m.l.c.p.she facing. Blood losing. Sir please suggest which medicine. Improve .hemoglobin. And blood levels. With out side effects.

B. Sc., BAMS
Ayurvedic Doctor, Madurai
Dear madam/sir Natural supplements that are antioxidant and supportive by nature would help your mother. I can help you. Pl consult me for ayurvedic advice. Thanks
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My sister is diagnosed with blood cancer. All type blood cancer. She was admitted last month 27. They started giving chemotherapy 1st phase is completed. Now she is infected with klebsiella pneumoniae and candida and jaundice. They started giving antibiotics pulse and wbc gone low and heart rate increased. Please tell whether she is curable or not. I'm not satisfied with hospital they are demanding more money but there is no improvement.

MBBS, Basic Life Support (B.L.S), Advanced Cardiac Life Support, Fellow of Academy of General Education (FAGE)
General Physician, Delhi
I am sorry to hear about your concern but will be happy to assist you. Klebsiella pneumoniae is a difficult infection to treat because of the organism's thick capsule. Klebsiella is best treated with third- and fourth-generation cephalosporins, quinolones, or carbapenems. Monotherapy is just as effective as a combination treatment in klebsiella pneumoniae because newer agents are used. Let's connect over a call so that we can discuss your concern in details and make a suitable treatment plan for you.
1 person found this helpful
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Hello my father has been diagnosed with myelofibrosis. Also he is suggreing from tuberculosis and taking medicine from last 3 months. He is also a sugar patients can myelofibrosis be treated by medicine or stem cell transplantation is the only method to cure it?

MBBS, Basic Life Support (B.L.S), Advanced Cardiac Life Support, Fellow of Academy of General Education (FAGE)
General Physician, Delhi
I am sorry to hear about your concern but will be happy to assist you. There is no drug therapy that can cure mf. The only potential cure for mf is allogeneic stem cell transplantation. But this procedure is risky for older patients and those with other health problems. Because mf primarily affects older adults, a stem cell transplantation is not a treatment option for most mf patients. Let's connect over a call so that we can discuss your concern in details and make a suitable treatment plan for you.
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Can mri of head and neck diagnose or give some clues about lymphoma. Please suggest.

MBBS, Basic Life Support (B.L.S), Advanced Cardiac Life Support, Fellow of Academy of General Education (FAGE)
General Physician, Delhi
I am sorry to hear about your concern but will be happy to assist you. An mri scan is helpful in detecting lymphoma that has spread to the spinal cord or brain. It can be helpful in other areas of the body as well, such as the head and neck area. Abdominal ultrasound: abdominal ultrasound may be used to examine enlarged lymph nodes, especially in the abdomen. Let's connect over a call so that we can discuss your concern in details and make a suitable treatment plan for you.
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I have dlc lymphocyte count of 44, with normal tlc and absolute lymphocyte count, meaning I have relative lymphocytosis. And I also have itching over body. Is it lymphoma? I took hgh 2 iu daily for 45 days for increasing my athletic performance.

MBBS, Basic Life Support (B.L.S), Advanced Cardiac Life Support, Fellow of Academy of General Education (FAGE)
General Physician, Delhi
I am sorry to hear about your concern but will be happy to assist you. The normal range for lymphocytes is between 800 and 5000 (0.8-5.0) lymphocytes per ml of blood. A normal lymphocytes percentage is 18-45% of total white blood cells. Let's connect over a call so that we can discuss your concern in details and make a suitable treatment plan for you.
1 person found this helpful
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Dear sir, for diagnosing lymphoma, which test is accurate mri scan or biopsy. Please suggest.

MBBS, Basic Life Support (B.L.S), Advanced Cardiac Life Support, Fellow of Academy of General Education (FAGE)
General Physician, Delhi
I am sorry to hear about your concern but will be happy to assist you a lymph node biopsy is the gold standard for diagnosing lymphoma. Often, it's the only test that can provide an official diagnosis. During the procedure, a specialist takes a sample of a lymph node. The sample is examined under a microscope for signs of lymphoma. Let's connect over a call so that we can discuss your concern in details and make a suitable treatment plan for you.
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My brother daughter 2 .5 years old has been identified blood cancer. She is in hospital. Would like to understand if the side effects of chemo can be reduced by diet, her immunity can be increased?

Bachelor of Ayurveda, Medicine and Surgery (BAMS)
Ayurvedic Doctor, Zirakpur
Yes, of course, ultimate nutrition will come from proper diet only. Dietition in cancer hospital will tell you or meet some vaidya.
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Sir my sister is a blood cancer patient age 31, treatmenting with imatinib tablet. Since 10 days. But she is suffering pain one by one in her body parts. Like right leg next left leg next hand. What the cause of this.

MD - Paediatrics
Pediatrician, Nagpur
Its unfortunate that your sister is suffering with blood cancer. As per history she might having cml, and receiving imatinib for treatment. Imatinib is known to cause musculoskeletal pain. Some time simple analgesic is helpful in getting relief of pain but many a times is due to more complex process that involve calcium and phosphate handling of body. I strongly advise you to consult your primary oncologist/hematologist, he might ask for some investigation, and may try to modify dose (depend on recent bcr-abl copy number). Hope this will help you.
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