Hypophosphatasia (HPP) is an uncommon fatal metabolic bone disease and it can affect men and women of any age, from infancy through adulthood. While Hypophosphatasia weakens and softens the bone, it causes skeletal abnormalities. The potential symptoms of Hypophosphatasia vary on the age of the patient and the signs can range from death in utero to dentition in adult life.
HOW IS HYPOPHOSPHATASIA DIAGNOSED?
Early loss of baby teeth is a possible indication of Hypophosphatasia. General physician may order for Laboratory tests like blood tests to detect low serum activity and urine tests to detect inorganic pyrophosphate levels. X-rays and other imaging tests help test the status of bones and teeth
HOW IS HYPOPHOSPHATASIA TREATED?
The treatment of hypophosphatasia is directed toward the specific symptoms and complications that may differ from individual to individual. Treatment may require the coordinated efforts of a team of specialists. Pediatricians, orthopedic surgeons, dental specialists (e.g. pediatric dentist), pain management specialist, and other healthcare professionals may need to systematically and comprehensively plan treatment. Genetic counseling may be of benefit for affected individuals and their families. With children with hypophosphatasia, psychosocial support for the entire family is essential as well.
DID YOU KNOW?
This problem usually starts off at the infancy stage and tends to get worse with age, leading to death.