Pregeb M 75 Capsule

Pregeb capsule contains Methylcobalamin in combination with Pregabalin. Methylcobalamin is one of the most important nutrients required in the human body. A lack of this vitamin can cause severe and permanent neurological damage. Pregabalin is an anticonvulsant and treats neurotic pain, shingles, seizures and fibromyalgia. Therefore, this medication helps in treating diabetic nerve pain, epilepsy, spinal cord injury, restless leg syndrome and generalised anxiety disorder.

This capsule works by binding to a certain region of the brain and reducing the pain signals sent out by the damaged nerves of the body. Women who are pregnant or breastfeeding must take medical help before using this medication.

• Peripheral Neuropathy

• Neuropathic Pain

• Decreased Potassium Level In Blood

• Allergy

• Leber's Disease

• Abdominal Pain

• Nausea Or Vomiting

• Skin Rash

• Difficulty In Breathing

• Chest Tightness

• Swelling Of Face, Lips, Eyelids, Tongue, Hands And Feet

• How long is the duration of effect?

  The peak of the effect can be observed within 3 hours after consumption. The effects can be felt within half an hour after intake.

• What is the onset of action?

  The onset of action is seen or felt within half and hour of consumption.

• Are there any pregnancy warnings?

  Yes, It is safe to consume this drug when pregnant. It is advised to take medical help before using this medication.

• Is it habit forming?

  No, it is not habit forming but it should not be consumed in excess.

• Are there any breast-feeding warnings?

  It is shown that the supplement is passed on through milk while breast-feeding. Hence it is not recommenced while breast feeding.

• Is It safe with alcohol?

  Alcohol decreases the level of vitamin B in the body, hence the consumption of alcohol is not recommended while taking this supplement.

• Is it safe to drive while on this medicine?

  Yes, it is safe to drive after consumption of the medicine.

• Does this affect kidney function?

  Excess consumption is know to damage the kidneys.

• Does this affect liver function?

  Excess consumption is not recommended if the person suffer from liver diseases.

• Are there any missed dose instructions?

  Try not to miss the dose, you need not take a double dose incase you have missed the previous one.

• Are there any overdose instructions?

  In case of overdose consult a doctor. The symptoms include nausea and uneasy stomach.

This capsule acts as a cofactor for enzyme methionine synthase, which transfers methyl groups for the regeneration of methionine from homocysteine. In anemia, it increases blood cell production by promoting nucleic acid synthesis in the bone marrow and by promoting maturation and division of erythrocytes. Pregabalin present in the medicine, is a GABA analog and binds to the voltage-gated calcium channels in the central nervous system. This causes a reduced release of neurotransmitters like serotonin, dopamine, substance P thus slowing down nerve signals.

Whenever you take more than one medicine, or mix it with certain foods or beverages, you"re at risk of a drug interaction.

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• Interaction with Alcohol

  Alcohol

  It decreases the effectiveness of medication.

• Interaction with Medicine

  Medicine

  Some medication that have a serious interaction with Methylcobalamin are Leukeran ( chlorambucil ), Prilosec( omeprazole), colcrys and Mitigare and the herbal supplement goldenseal.

• Interaction with Food

  Food

  Since it’s derived from food sources there is no severe reaction with food.

• Interaction with Disease

  Disease

  Vitamin B12 does not interact with diseases.

• Pregabalin- Drug Information Portal [Internet]. druginfo.nlm.nih.gov. 2019 [Cited 23 April 2019]. Available from:

  https://druginfo.nlm.nih.gov/drugportal/name/pregabalin

• Pregabalin: Uses, Side effects, Dosage- Drugs Bank [Internet]. drugsbanks.com. 2017 [Cited 25 April 2019]. Available from:

  https://www.drugsbanks.com/important-information-about-pregabalin/

• Methylcobalamin- Drug Information Portal [Internet]. druginfo.nlm.nih.gov. 2019 [Cited 23 April 2019]. Available from:

  https://druginfo.nlm.nih.gov/drugportal/name/methylcobalamin

• Methylcobalamin- DrugBank [Internet]. Drugbank.ca. 2018 [Cited 27 April 2019]. Available from:

  https://www.drugbank.ca/drugs/DB03614