Paget disease is a disorder that involves abnormal bone destruction and regrowth. This results in deformity of the affected bones. The disease can cause affected bones to become fragile and misshapen. Paget's disease of bone most commonly occurs in the pelvis, skull, spine and legs. Signs and symptoms can include:
§ Enlarged bones
§ Broken bones
§ Damaged cartilage in joints.
HOW IS PAGET'S DISEASE OF BONE DIAGNOSED?
Tests that may indicate Paget disease include:
• Bone scan
• Bone x-ray
• Elevated markers of bone breakdown (for example, N-telopeptide)
• Alkaline phosphatase (ALP), bone specific isoenzyme
• Serum calcium
HOW IS PAGET'S DISEASE OF BONE TREATED?
Osteoporosis drugs (bisphosphonates) are the most common treatment for Paget's disease of bone. Some bisphosphonates are taken by mouth, while others are given by injection. Oral bisphosphonates are generally well-tolerated, but may irritate your gastrointestinal tract. In rare cases, surgery might be required to help fractures heal,replace joints damaged by severe arthritis, realign deformed bone and reduce pressure on nerves
DID YOU KNOW?
The risk of Paget's disease of bone increases with age. Your risk also increases if any family members have the disorder.