Toficalm 100Mg Tablet

Manufacturer: Sun Pharmaceutical Industries Ltd
Medicine composition: Tofisopam
Prescription vs OTC: Prescription by Doctor required

Tofisopam is a benzodiazepine derivative. It is used to treat depression. It functions by regulating the level of a chemical known as catecholamine which is present in the human body. Women who are pregnant or breastfeeding must consult doctor before using this medication.

The recommended dose for adults is about 50 to 100 mg, one to three times per day. It is contraindicated for patients with aggressive-impulsive psychopathy, and for pregnant women. This medication may cause sleeplessness, if this condition continues to persist, consider discontinuing the medication.

Symptoms of overdose include dizziness, drowsiness, pinpoint pupils, nausea, vomiting. There is no known antidote for buspirone, treatment is supportive.

Take only as directed; do not increase dose or take more often than prescribed. May take 2-3 weeks to see full effect; do not discontinue without consulting prescriber. Do not use excessive alcohol or other prescription or OTC medications (especially pain medications, sedatives, antihistamines, or hypnotics) without consulting prescriber.

Maintain adequate hydration (2-3 L/day of fluids unless instructed to restrict fluid intake). You may experience drowsiness, lightheadedness, impaired coordination, dizziness, or blurred vision (use caution when driving or engaging in tasks requiring alertness until response to drug is known); or upset stomach, nausea (small frequent meals, frequent mouth care, chewing gum, or sucking lozenges may help).

Report persistent vomiting, chest pain or rapid heartbeat, persistent CNS effects (eg, confusion, restlessness, anxiety, insomnia, excitation, headache, dizziness, fatigue, impaired coordination), or worsening of condition.

Information given here is based on the salt content of the medicine. Uses and effects of the medicine may vary from person to person. It is advisable to consult a Psychiatrist before using this medicine.

This medication helps in treating the following problem in the human body:

  • Depression

  • Anxiety Disorder

The side effects of this medication are as follows:

  • Is It safe with alcohol?

    Interaction with alcohol is unknown. Please consult your doctor.
  • Are there any pregnancy warnings?

    Pregnant women must consult doctor before using this medication. Please consult your doctor.
  • Are there any breast-feeding warnings?

    Breastfeeding women should not use this medication. Please consult your doctor.
  • What is the onset of action?

    The medicine action will be initiated within 40-60 minutes.
  • How long is the duration of effect?

    The action will remain active for 2-3 hours.
  • Are there any missed dose instructions?

    If you miss a dose of Tofisopam, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular schedule. Do not double the dose.
  • Are there any overdose instructions?

    Consult your doctor in case of overdose.

This medication doesn’t combine to benzodiazepine binding site. GABA receptor is the binding site. This drug behaves as the isoenzyme-selective inhibitor of the enzyme, phosphodiesterases with great affinity.

Whenever you take more than one medicine, or mix it with certain foods or beverages, you"re at risk of a drug interaction.

  • Interaction with Lab Test

    Increased level of AST, ALT, growth hormone(s), prolactin (S) can be observed.
  • Interaction with Medicine

    • Erythromycin, clarithromycin, itraconazole, ketoconazole, and grapefruit juice may result in large increases in buspirone concentrations (dizziness, sedation).
    • Enzyme inducers (carbamazepine, rifampin) may reduce serum concentrations of buspirone resulting in loss of efficacy.
    • Buspirone should not be used concurrently with an MAO inhibitor due to reports of increased blood pressure.
    • Diltiazem and verapamil may increase serum concentrations of buspirone; consider a dihydropyridine calcium channel blocker.
  • Interaction with Disease

    Safety and efficacy not established in children <18 years of age; use in hepatic or renal impairment is not recommended; does not prevent or treat withdrawal from benzodiazepines. Low potential for cognitive or motor impairment. Use with monoamine oxidase inhibitors may result in hypertensive reactions.
  • Interaction with Food

    Food may decrease the absorption of buspirone, but it may also decrease the first-pass metabolism, thereby increasing the bioavailability of Toficalm 100Mg Tablet.
Disclaimer: The information produced here is best of our knowledge and experience and we have tried our best to make it as accurate and up-to-date as possible, but we would like to request that it should not be treated as a substitute for professional advice, diagnosis or treatment.

Lybrate is a medium to provide our audience with the common information on medicines and does not guarantee its accuracy or exhaustiveness. Even if there is no mention of a warning for any drug or combination, it never means that we are claiming that the drug or combination is safe for consumption without any proper consultation with an expert.

Lybrate does not take responsibility for any aspect of medicines or treatments. If you have any doubts about your medication, we strongly recommend you to see a doctor immediately.

Popular Questions & Answers

Content Details
Written By
PhD (Pharmacology) Pursuing, M.Pharma (Pharmacology), B.Pharma - Certificate in Nutrition and Child Care
Reviewed By
MBBS, Master in Healthcare Administration, Diploma in Occupational Health
General Physician
Table of Content
About Toficalm 100Mg Tablet
What are the uses of Toficalm 100Mg Tablet
What are the contraindications of Toficalm 100Mg Tablet ?
What are the side effects of Toficalm 100Mg Tablet ?
Key highlights of Toficalm 100Mg Tablet
What are the dosage instructions?
How does this medication work?
What are the interactions of Toficalm 100Mg Tablet ?