Letroz 2.5 MG Tablet

Manufacturer: Sun Pharma Laboratories Ltd
Medicine composition: Letrozole
Prescription vs.OTC: Prescription by Doctor not required
Last Updated: January 28, 2022

Letroz 2.5 MG Tablet is primarily used to treat Breast Cancer in Post-Menopausal Women. Sometimes, excess Estrogen in the body can stimulate Cancerous Cells to grow in the Breast. It is commonly used to treat estrogen-dependent Tumors.

Letroz 2.5 MG Tablet belongs to a group of drugs called Aromatase Inhibitors that prevents the conversion of Androgen to Estrogen in women. In Menopausal Women, the Ovaries do not produce Estrogen. Instead, the Body Fat, using a Protein called Aromatase, produce it. Letroz 2.5 MG Tablet inhibits the production of Estrogen and thus prevents the growth of a Tumor.

It also increases the thickness of the Endometrium and improves Follicular development in the Ovaries. This medication can also induce Ovulation in females if they are unable to do so naturally. Sometimes, this drug can be also prescribed to men with Breast Cancer. It is only prescribed if the biopsy shows Oestrogen Receptors within the cells.

Letroz 2.5 MG Tablet helps to reduce chances of Cancer returning to the same breast or metastasize. It can be taken as a tablet, once a day for 5 days, with or without food. No experience with letrozole overdose has been reported. In single-dose studies, the highest dose used was 30 mg, which was well tolerated.

Lethality was observed in mice and rats following single oral doses that were greater than or equal to 2000 mg/kg (~4000 to 8000 times the maximum daily doses recommended in humans); death was associated with reduced motor activity, ataxia, and dyspnea.

Lethality was observed in cats following single I.V. doses that were greater than or equal to 10 mg/kg (~50 times the maximum daily dose recommended in humans): death was preceded by depressed blood pressure and arrhythmias.

Firm recommendations for treatment are not possible; emesis could be induced if the patient is alert. In general, supportive care and frequent monitoring of vital signs are appropriate. Take as directed, without regard to food.

You may experience nausea, vomiting, or loss of appetite (frequent mouth care, frequent small meals, chewing gum, or sucking lozenges may help); musculoskeletal pain or headache (mild analgesics may offer relief); sleepiness, fatigue, or dizziness (use caution when driving, climbing stairs, or engaging in tasks that require alertness until response to drug is known); constipation (increased exercise, or dietary fruit or fluids may help); diarrhea (boiled milk or yogurt may help); loss of hair (will grow back).

Report chest pain, palpitations, or swollen extremities; vaginal bleeding or hot flashes; unusual coughing or difficulty breathing; severe nausea; muscle pain; or skin rash.

This medicine is primarily used for the following condition:

Some of the side effects caused by this medication are

  • Hot Flashes

  • Bone Pain

  • Chronic Musculoskeletal Pain

  • Arthralgia

  • Flushing

  • Asthenia

  • Edema (Swelling)

  • Headache

  • Dizziness

  • How long is the duration of effect?

    The effect of this medication lasts for an average duration of 2 days.
  • What is the onset of action?

    The onset of action of this medication can be observed in 2 to 6 weeks.
  • Are there any pregnancy warnings?

    Pregnant women must consult doctor before using this medication.
  • Is it habit forming?

    No habit forming tendencies were reported.
  • Are there any breast-feeding warnings?

    This drug is incompatible with breastfeeding women. There is an increased risk of foetal malformation.
  • Is It safe with alcohol?

    It is unsafe to drink alcohol while undergoing this hormone therapy for increases chances of headaches and nausea.
  • Is it safe to drive while on this medicine?

    Drive with caution if you are suffering from any of the side-effects.
  • Does this affect kidney function?

    No dosage adjustment is required in patients with renal impairment if Clcr greater than or equal to 10 mL/minute.
  • Does this affect liver function?

    No dosage adjustment is recommended for patients with mild-to-moderate hepatic impairment. Patients with severe impairment of liver function have not been studied; dose patients with severe impairment of liver function with caution.

Below is the list of medicines, which have the same composition, strength and form as Letroz 2.5 MG Tablet , and hence can be used as its substitute.

  • Are there any missed dose instructions?

    It is advised not to miss any dose. If you missed any dose, you should contact your doctor immediately.
  • Are there any overdose instructions?

    Seek emergency medical treatment or contact the doctor in case of an overdose.

Letroz 2.5 MG Tablet is nonsteroidal, competitive inhibitor of the aromatase enzyme system which binds to the heme group of aromatase, a cytochrome P-450 enzyme which catalyzes conversion of androgens to estrogens (specifically, androstenedione to estrone and testosterone to estradiol). This leads to inhibition of the enzyme and a significant reduction in plasma estrogen levels. Approximately 30% of breast cancers are sensitive to this estrogen deprivation.

Whenever you take more than one medicine, or mix it with certain foods or beverages, you"re at risk of a drug interaction.

  • Interaction with Alcohol

    Interaction with alcohol is unknown. It is advisable to consult your doctor before consumption.
  • Interaction with Medicine

    This medication interacts with other estrogen-containing drugs like hormone replacement therapy (HRT) and other drugs like ethinylestradiol, tamoxifen, cholera vaccine and eluxadoline.
  • Interaction with Disease

    • This medicine is dangerous to be used in patients with existing liver disease. The drug increases the enzyme level in the liver.
    • Letroz 2.5 MG Tablet was not mutagenic in in vitro tests but was observed to be a potential clastogen in in vitro assays. Repeated dosing caused sexual inactivity in females and atrophy in the reproductive tract in males and females at doses of 0.6 mg/kg, 0.1 mg/kg, and 0.03 mg/kg in mice, rats, and dogs, respectively (~1 mg/kg, 0.4 mg/kg, and 0.4 mg/kg the maximum recommended human doses, respectively).
    • Increases in AST, ALT, and GGT greater than or equal to 5 times the upper limit of normal (ULN) and of bilirubin greater than or equal to 1.5 times the ULN were most often associated with metastatic disease in the liver.

Ques: What is Letroz 2.5 MG Tablet?

Ans: Letroz 2.5 MG Tablet comes under the class of drugs known as an aromatase inhibitor. It is an anticancer agent which helps in the treatment of breast cancer.

Ques: What is Letroz 2.5 MG Tablet used for?

Ans: Letroz 2.5 MG Tablet is used for the treatment and prevention from conditions and symptoms of diseases like advanced breast cancer in postmenopausal women, spreading of cancer to other parts of the body and cancer recurrence.

Ques: What are the side effects of Letroz 2.5 MG Tablet?

Ans: Possible side-effects include bone fracture, chest pain, dizziness, headache, increased sweating, and back pain.

Ques: Is Letroz 2.5 MG Tablet a steroid, a hormone, a selective estrogen receptor modulator, or cytotoxic?

Ans: Letroz is not a steroid, hormone, selective estrogen receptor modulator or cytotoxic drug. It comes under the class of drugs known as an aromatase inhibitor.

Ques: How long do I need to use Letroz 2.5 MG Tablet before I see improvement of my conditions?

Ans: This medication should be consumed till complete eradication of disease, so it is advised to use till the time directed by your doctor.

Ques: At what frequency do I need to use Letroz 2.5 MG Tablet?

Ans: This medication is generally consumed once in 2 day as the time interval upto which this medication has an impact is around 48 hours.

Ques: Should I use Letroz 2.5 MG Tablet empty stomach, before food or after food?

Ans: The action of salts involved in the medication does not depend on using it pre-meal or post-meal.

Ques: What are the instructions for storage and disposal of Letroz 2.5 MG Tablet?

Ans: The medication contains salts which are suitable to store at room temperature as keeping the medication above or below can cause an inadequate effect.

Ques: Why have I been prescribed Letroz 2.5 MG Tablet?

Ans: This drug is an aromatase inhibitor. It is generally prescribed to treat breast cancer in women. Sometimes, it is also used to treat infertility caused due to an ovulation.

Ques: How does Letroz 2.5 MG Tablet work?

Ans: This drug is also known as an anti-estrogen drug. It is called so because it acts by reducing the production of estrogen in your body by blocking the enzyme aromatase, which is responsible for the production of estrogen.

Ques: For how long should I take Letroz 2.5 MG Tablet?

Ans: It is advised to consult the doctor and consume it as prescribed by your doctor.

Ques: If I am taking Irbesartan to control my blood pressure, can I take Letroz 2.5 MG Tablet too?

Ans: Yes, you can take Irbesartan and Letroz 2.5 MG Tablet together.

Ques: Does Letroz 2.5 MG Tablet affect vision?

Ans: Although it is very uncommon, this drug may cause cataract. So, if you experience blurred vision or eye irritation, consult your doctor immediately.

Ques: Does Letroz 2.5 MG Tablet cause bone loss?

Ans: It may cause thinning or wasting of your bones (osteoporosis), which is due to the decrease in estrogen levels in your body. Your doctor may decide to measure your bone density (a way of monitoring for osteoporosis) before, during, and after treatment.
Disclaimer: The information produced here is best of our knowledge and experience and we have tried our best to make it as accurate and up-to-date as possible, but we would like to request that it should not be treated as a substitute for professional advice, diagnosis or treatment.

Lybrate is a medium to provide our audience with the common information on medicines and does not guarantee its accuracy or exhaustiveness. Even if there is no mention of a warning for any drug or combination, it never means that we are claiming that the drug or combination is safe for consumption without any proper consultation with an expert.

Lybrate does not take responsibility for any aspect of medicines or treatments. If you have any doubts about your medication, we strongly recommend you to see a doctor immediately.

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Content Details
Written By
PhD (Pharmacology) Pursuing, M.Pharma (Pharmacology), B.Pharma - Certificate in Nutrition and Child Care
Reviewed By
MD-Pharmacology, MBBS
Table of Content
About Letroz 2.5 MG Tablet
What are the uses of Letroz 2.5 MG Tablet
What are the contraindications of Letroz 2.5 MG Tablet ?
What are the side effects of Letroz 2.5 MG Tablet ?
Key highlights of Letroz 2.5 MG Tablet
What are the substitutes for Letroz 2.5 MG Tablet ?
What are the dosage instructions?
How does this medication work?
What are the interactions of Letroz 2.5 MG Tablet ?
FAQs about Letroz 2.5 MG Tablet