Soluble Transferrin Receptor sTFR Test

Transferrin is a protein present in blood that binds to iron. This bound complex then binds to Soluble Transferrin Receptors (sTFRs) on cells. When the number of complexes decrease, the number of vacant sTFRs increase. As a result, these sTFRs are released into the blood stream. Now, the number of the sTFRs present in the blood stream can indicate deficiency of iron in the system. Deficiency of iron, usually caused by lack of iron in the diet causes anaemia. This anaemia can either be due to above mentioned deficiency, or because of chronic illness. The sTFR Assay is used to identify whether an anaemia affected patient suffers from deficiency or some other chronic illness.

The sample used for the test is a blood sample. No specific preparations are necessary. The doctor must be informed of any prescribed drugs the patient is consuming. It is recommended that the patient wear a short sleeved shirt.

The blood sample will be evaluated for presence of sTFRs. A high number of sTFRs in the blood of an anaemic patient indicates deficiency anaemia. A normal number of sTFRs in the blood of an anaemic patient indicates a chronic disease. A high number of sTFRs in the blood of a normal person can indicate an over accumulation of iron. Further tests can be performed to assess the chronic disease, if any.

The blood sample is drawn from the vein on the patient's arm. The arm of the patient will be cleaned with an alcohol swab. A sterile needle will be inserted into the vein. About 2ml blood will be drawn from the patient's arm. The site will be cleaned with a cotton swab.