HE4 Index test is conducted on a sample of blood to measure level of HE4 in blood. It is performed to detect Epithelial Cancer and Ovarian Cancer it is also well-known as HE4 with Roma Index test. This test assesses human epididymis protein 4 (HE4), a new ovarian cancer biomarker, both only and in grouping with CA 125 as a diagnostic marker for ovarian cancer. The HE4 test is not intended to be used to monitor mucinous epithelial ovarian cancers since it is hardly ever high in these cancers.