Warfarin CYP2C9 and VKORC1 Sensitivity Test in Ghaziabad

Warfarin is an anticoagulant. It reduces the activity of the vitamin K dependent clotting factors to stop the blood from clotting. It has the measure role in thrombotic disorders. The dose of the drug from person to person based on the INR response of the patient. As per the result of it the condition of the patient is treated. Genotype CYP2C9 and VKORC1 of the patient can be determined to optimise the dose of the warfarin. The genotype CYP2C9 encodes an enzyme which monitors the metabolism of warfarin. Many variants CYP2C9 alleles might be present in the body which are associated with the reduced enzyme activity and lower clearance rate of the warfarin. Patients with at least one allele of the CYP2C9 have reduced metabolism of warfarin leading to the higher concentration of it. The target of the warfarin, vitamin K epoxide reductase enzyme, is encoded by VKORC1 gene. Patients with -1639G>A polymorphism at the promoter region of the VKORC1 gene are more sensitive to the warfarin drug and require lower dose of it.