RBC Fragility (Test Osmotic Fragility Test) is a blood test to detect whether red blood cells are more likely to break down causing conditions called hereditary spherocytosis and thalassemia. Hereditary spherocytosis makes red blood cells more fragile than normal. With thalassemia, some red blood cells are more fragile than normal, but more of them are less fragile than normal.
But this test is highly risky, since veins and arteries vary in size from one person to another, and from one side of the body to the other, obtaining a blood sample from some people may be more difficult than from others.
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