IHC, Calponin Test in Chennai

Basic calponin (calponin-h1) is a 34kD protein which exhibits a high degree of homology to acidic and neutral calponins at its N-terminal region. It is an actin, tropomyosin and calmodulin binding protein thought to be involved in the regulation of smooth muscle contraction. The expression of calponin is restricted to smooth muscle cells and is a marker of the differentiated contractile phenotype of developing smooth muscle. Vascular smooth muscle cells convert to a synthetic dedifferentiated phenotype when this protein is lost. It is thought that basic calponin exerts its effect via the cortical actin cytoskeleton. Basic calponin mRNA is expressed in smooth muscle of prostate, bowel and aorta whereas neutral and acidic calponin mRNAs are expressed in non-smooth muscle tissues such as heart, placenta, lung, kidney, pancreas, spleen, testis and ovary as well as in smooth muscle-containing tissues