A ganglioside is a molecule of a glycosphingolipid with one other sialic salts sialic acids (e.g. n-acetylneuraminic acid, NANA) linked on the sugar chain. NeuNAc, an acetylated derivative of the carbohydrate sialic acid, makes the head groups of gangliosides anionic at pH 7, which distinguishes them from globosides.
The name ganglioside was first applied by the German scientist Ernst Klenk in 1942 to lipids newly isolated from ganglion cells of the brain. More than 60 gangliosides are known, which differ from each other mainly in the position and number of NANA residues. It is a component of the cell plasma membrane that modulates cell signal transduction events, and appears to concentrate in lipid rafts
No special preparation is needed. Inform your doctor if you are on any medications or have any underlying medical conditions or allergies before starting the procedure. It’s a simple blood test so, it’s better not to eat past hour to get best results. Your doctor depending on your condition will give specific instructions.
May be useful when assessing for primarily motor neuron disease and motor neuropathies. Test by itself is not diagnostic and should be used in conjunction with other clinical parameters to confirm disease.
Process of obtaining blood sample in adults: A band is wrapped around the arm, 3-4 inches above the collection site (superficial vein that lies within the elbow pit) The needle cap is removed and is held in line with the vein, pulling the skin tight
The required amount of blood sample is collected by pulling the plunger of the syringe out slowly The wrap band is removed, gauze is placed on the collection site, and the needle is removed
The blood is immediately transferred into the blood container, which has the appropriate preservative/clot activator/anti-coagulant The syringe and the needle are disposed into the appropriate “sharp container” for safe and hygienic disposal.
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