Burkitt lymphoma-Translocation 8/14 Test

Burkitt lymphoma is a cancer of the lymphatic system, particularly B lymphocytes found in the germinal center. It is a solid tumor of B lymphocytes, the lymphocytes that the immune system uses to make antibodies. The genes for making antibodies are located on chromosomes. Genes like 14 (the heavy [H] chains), 2 (kappa light chains), and 22 (lambda light chains) are expressed only in B lymphocytes because only B cells have the necessary transcription factors for the promoters and enhancers needed to turn these antibody genes 'on'

No such preparation is necessary.

First step of treatment is intensive chemotherapy. The effects of chemotherapy, with all the cancer, depend on the timing of the diagnosis. With rapidly growing cancers such as burkits, cancer slowly gives a much faster response than slow-growing cancer; this severe reaction to chemotherapy can be dangerous for the patient because there is an event called 'Tumor Lysis Syndrome' which can occur. Patient monitoring and adequate hydration is essential during this process. Since burkits have high tendency to spread in lymphoma, CNS, intrahepatical chemotherapy with methotrexate and / or ARA-C and / or phenynisolone is given along with systemic chemotherapy.