Calprotectin is a stool (fecal) test that is used to detect inflammation in the intestines and digestive system. Intestinal inflammation is associated with bacterial infections and in people with inflammatory bowel disease (IBD). Signs and symptoms of IBD will vary from person to person and over time. They may include one or more of the following: Bloody or watery diarrhea Abdominal cramps or pain Fever Weight loss Rectal bleeding Weakness