Rheumatoid Factor (RF) is a classification of immunoglobulins (Igs) that has various affinities and isotypes, were first detected in people with more than 70 years of age. However, there are still few more to detect about the mechanisms essential its production, pathological effects, and role. The symptoms for Rheumatoid may vary depending upon the patient. Rheumatoid may develop all of a sudden and develop slowly, or even occur with no symptoms. Some of the symptoms include joint pains and stiffness in hands, fingers, feet, and wrists. The most common symptom also has inactivity of sense, during the morning. Apart from the join paints and stiffness, some of the following symptoms may also occur: