IGFBP-3 or Insulin-like-Growth-Factor-Binding-Protein-3 needs a blood sample for getting the right report. The report clarifies the actual cause of abnormal reaction of Human Growth Hormone. Especially, the abnormality is shown in childhood. The unnatural supply of HGH affects the skeleton of the face, bones and sexual maturity. While the people are sleeping, the HGH is coming out from pituitary gland much and forms the human body. This hormone is the most important molecule that crafts the perfect body. If the human growth hormone doesn't react properly, then the person would be unable to proper metabolism, sexuality and body development. If anybody is affected by this symptom, then the IGFBP-3 test is applied to check the exact level.