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In Vitro Fertilization (IVF) Tips

How Natural IVF Differs From Mini IVF?

Dr. Sameer Pahlajani 88% (27 ratings)
MBBS
IVF Specialist, Raipur
How Natural IVF Differs From Mini IVF?

Suffering from the problem of infertility can be a heartbreaking as well as a very frustrating process but still with different kinds of IVF treatments available today, a lot of women can realize their dreams of having their own family. In Vitro Fertilization is a laboratory procedure where the sperm and egg are fertilized outside the body. It has been more than 35 years since the first baby was born through this process of IVF and now it has become the go-to method for treatment regarding reproduction, which assists in the birth of over 5 million babies. With the availability of different kinds of IVF treatments currently, to navigate one’s way through the in vitro fertilization process can seem to be quite confusing as well as intimidating.

Now, we take a look at the difference between the types of IVF treatments and see if they are right for a woman.

Different Types of IVF -

Since the time IVF came into being, more than three decades ago, it has become the leading form of assisted reproduction, having an estimated amount of 70000 babies per year getting conceived through this procedure. The procedure of IVF involves a really complex series of procedures where an egg gets removed from the ovaries of a woman and fertilized with sperm in a laboratory. The fertilized egg, which is called an embryo then, gets returned to the womb of the woman for its growth and development.

  • Natural Cycle IVF: Natural Cycle IVF bears similarity with the standard IVF treatment but this takes place without having to use medication for stimulating the ovary leading to the preparation of multiple eggs. Natural IVF basically monitors the ovulation cycle of a patient with the intention to retrieve only one egg. This is unlike conventional IVF, which requires retrieval of multiple eggs. Women who opt for Natural IVF due to the process being more economical compared to the traditional treatment. Natural Cycle IVF requires less time as compared to the traditional one and is thought to be a safer as well as stress-free treatment option by certain experts.
  • Mini IVF: Minimal Stimulation IVF or Mini IVF is a kind of IVF, which is supposed to be somewhere between Natural IVF and Traditional IVF. The Mini IVF treatment is different from the Traditional IVF, with regard to how it gets administered through medicines. In case of Mini IVF treatment, less amount of medication gets administered by the specialists, so that there can only be production of two to three eggs at a time, in comparison to 10 or more in case of conventional IVF.

At the time of treatment, the retrieval of eggs and fertilization take place just like they are done in any other IVF process. The only difference lies in the stimulation part, which is lot less in this case compared to regular In Vitro Fertilization. Despite Mini IVF being suggested as a gentler approach to IVF, some researchers feel that less number of eggs might reduce the possibility of getting success.

Despite the positives, certain fertility experts send out a warning due to the significantly low chance of pregnancy with this process. In case you have a concern or query you can always consult an expert & get answers to your questions!​

1 person found this helpful

Frozen Embryo Transfer - When Is It Required?

Dr. Anuj Sharma 95% (810 ratings)
MBBS, MS - General Surgery, Fellowship of Indian Association of Gastrointestinal Endo Surgeons (FIAGES), Fellowship in Sexual Medicine
IVF Specialist, Meerut
Frozen Embryo Transfer - When Is It Required?

A frozen embryo transfer is a type of IVF treatment wherein a cryopreserved embryo, created in a full cycle of IVF is thawed enough to soften it up and hence transferred to the uterus of a woman. The embryo which has been cryopreserved might well be from a woman, who had previously gone through a typical IVF cycle or it can also be a donor embryo. In case a donor embryo gets used, then obviously that embryo is neither related to the woman nor to her partner.

On most occasions, a frozen embryo transfer takes place when there are extra embryos available after a normal IVF cycle. The usually preferred option is to have a fresh transfer.

Reasons behind Choosing To Have a Frozen Embryo Transfer-In Vitro Fertilization Cycle (FET - IVF)

One can choose to go for a Frozen Embryo Transfer cycle if:

A fresh IVF transfer fails and a woman has embryos which are cryopreserved: IVF Treatment cycle can result in the emergence of one or more than one embryo. The safe option is to get only one embryo transferred or a maximum of two at a time. In order to ensure complete reduction of risk, certain doctors even recommend women to go for Elective Single Embryo Transfer, especially for those with a good prognosis.

On certain situations, an IVF cycle can result in extra embryos. Most women opt to freeze or cryopreserve their extra embryos. For instance, a woman gets five embryos. Now, let's presume that a doctor recommends a woman to go for elective single embryo transfer. This would ensure that only one out of the five embryos will get transferred, whereas the remaining four embryos will be cryopreserved. It can well happen that one embryo transfer does not lead to successful pregnancy, then in that scenario, there would be a couple of options: a) A woman can go for another fresh complete IVF cycle or b) She can transfer either one or two of her embryos which were previously cryopreserved.

A woman may want to give her IVF conceived child a sibling: If a fresh embryo transfer results in pregnancy, then through the last example, given above, a woman can have four embryos, which are waiting to get cryopreserved. Cryopreserved embryos can be on liquid nitrogen for an indefinite period of time. Cryopreserved embryos can be used for second child.

The embryos are screened genetically: There are two assisted reproductive techniques in the form of Preimplantation Genetic Diagnosis and Preimplantation Genetic Screening, which ensure embryos to get screened for any kind of specific disease or defects. This is carried out through a biopsy of the embryo on the 3rd or on the 5th day after fertilization and after the egg gets retrieved. On certain situations, the results get back in time for performing a fresh embryo transfer. In case the biopsy or genetic test result is complex and more time gets consumed, in that case, all those embryos whose biopsy were taken get cryopreserved.

2406 people found this helpful

IVF - Know The Gains Of It!

Dr. Vishwanath N Shivanagutti 87% (10 ratings)
MBBS, MS - Obstetrics and Gynaecology
IVF Specialist, Hubli
IVF - Know The Gains Of It!

For centuries, there have been cases where women were unable to conceive a child. The reason could in both, female or male body. Despite knowing the reason, it wasn’t possible to treat such patients or let them have a chance at parenting. Many such marriages would end in a divorce that was unable to conceive a child, but mostly, the motherly instincts of a childless woman were hurt deeply and inconsolably. Thanks to the IVF, which stands for- In-Vitro Fertilization, that it has given a newly found chance at parenting to those who cannot do it naturally?

Even though man developed this technique of artificial fertilization, it is greatly unlikely to have successful implantation or a successful pregnancy. The chances are meagre in most cases given the fact that IVF is indeed, an experiment which does not claim 100% proficiency or results. No one can guarantee 100% success but after meticulous evaluation one can try and assure maximum success. Therefore, whoever goes for an IVF treatment is always, more or less, in the shadow of the doubt whether it will turn out positive or not! This brings us to the most asked question, IVF: how successful is it? Well, the answer merely lies in the statistics and the reason for seeking the treatment.

To start with, there are a number of factors on which the success of IVF depends upon, for example:

  • The age of women

  • Causes of Infertility

  • The quality of egg in the female body

  • The quality of sperm

  • The quantity of sperm released by the male body

These are the primary factors which influence the success of IVF treatment. If you consider recent statistics, it says that women who receive frozen egg transfers are more likely to have a successful pregnancy than those with a fresh transfer. A frozen egg transfer is not only best recommended by the doctors but it has a higher statistical success rate. This is mainly due to the fact which says that during a frozen egg transfer the hormonal condition in the woman is better adjusted and in control. Moreover, the mother is less like to suffer from any pregnancy-related complications when subjected to frozen egg transfer.

Conclusion: Deciding the success rate of an IVF treatment is highly impossible because the situation with every couple is unique to their own health conditions and other factors. But medical science is advancing by the day which means the possibility of success is most likely to be increased in the near future. One way to ensure the success is thorough research about relatable cases and in-depth talk with your doctor.

2408 people found this helpful

IVF Vs Tubal Ligation Reversal!

MD Gynaecology
IVF Specialist, Kolkata
IVF Vs Tubal Ligation Reversal!

There are many different modes of contraception available to women today. Tubal ligation is considered the most effective amongst these. This involves permanently blocking the fallopian tubes by clipping, cutting or burning them. The only downside to this form of contraception is its permanence. Conceiving a child after tubal ligation is difficult but not impossible. The two modes of treatment available to women who have undergone this procedure are tubal ligation reversal and IVF.

As the name suggests, a tubal ligation reversal procedure reconnects the fallopian tubes. This procedure involves making a 10-15cm incision in the lower abdomen. Tiny stitches are then used to reconnect the two blocked ends of the fallopian tubes. This procedure is usually performed while the patient is under general anaesthesia and could involve a few days of hospital stay. A tubal ligation reversal procedure can also be performed as a keyhole procedure. This procedure gives a woman a chance to conceive naturally. The younger the woman is, the higher are her chances of conception after this procedure. In the case of patients over the age of 40 years, the chances of a successful conception after this procedure are very slim.

IVF or In vitro fertilization involves harvesting the eggs from the patient’s ovaries, fertilizing them in a lab and then reintroducing the embryo into the patient’s uterus. When it comes to assisted reproductive therapy, IVF is more successful than a reverse tubal ligation. Another advantage of IVF over reverse tubal ligation is the fact that with IVF the woman will still have an efficient form of birth control even after the pregnancy. IVF also does not need any hospitalization. One of the downsides of a reverse tubal ligation is the high risk of tubal ectopic pregnancy. In this case, the fertilized egg is implanted outside the uterus. This type of pregnancy cannot usually be taken to full term and can be life-threatening for the woman.

On the flip side, IVF can often need repeat cycles which often works out to be quite expensive. These costs can be an issue for a woman who wants more than one child. In the case of reverse tubal ligation, the costs are a one-time investment.

One of the other common side effects of IVF is multiple pregnancies. For women who do not want more than one child, this can again be a problem. Thus, both forms of treatment have their advantages and disadvantages.

The best form of treatment for you can be decided only by a fertility expert.

4972 people found this helpful

IVF - Know Misconceptions About It!

Dr. Vishwanath N Shivanagutti 87% (10 ratings)
MBBS, MS - Obstetrics and Gynaecology
IVF Specialist, Hubli
IVF - Know Misconceptions About It!

Even though the process of In Vitro Fertilisation has been around for a while now, there are still a few myths and misconceptions connected to it. Here we dispel some of the most popular myths about IVF treatment:

Myth #1: Women should take bed rest after embryo transfer
Reality: False

Doctors have said that it is absolutely not required to put your life on hold after IVF treatments. Further, it can actually be detrimental because it prevents normal fluctuations in heart rate and blood pressure.

Myth #2: IVF causes multiple births
Reality: False

While it is true that earlier, IVF clinics often transferred more than one embryo into the uterus of the woman because success rates were much lower in the past, today the process is much more advanced. While it’s true that during the treatment the ovaries are stimulated to produce multiple eggs, these eggs are removed from the body before fertilisation. Fertilisation happens in the laboratory under specific conditions, thus the term “test-tube baby”, and the resulting embryo is implanted into the mother.

Myth #3: Babies born through IVF have higher chances of birth defects, illness and developmental delays
Reality: False

This is a very common myth prevalent among many women, primarily due to a lack of understanding of the science behind IVF treatments. Numerous research has revealed that the likelihood of any such abnormalities in children born after IVF is not higher than those conceived in a natural way. The child’s health depends more on the health of the parents than on the way of conception. The genetic makeup of the mother and father can influence what kind of genetic defects, if any, their child will have. Therefore, if you are worried about the health of your future child, it is advisable to undergo a PGD (Preimplantation genetic diagnosis) screening before going for IVF treatments. Further, during the embryonic state, that is when the embryos are growing and being prepared to be transferred to the uterus, the doctors can detect specific chromosomal and genetic abnormalities and hence inform the parents about them.

Myth #4: It is not possible to get pregnant in the 1st attempt
Reality: It depends

This myth arises from the fact that IVF treatment does not necessarily guarantee a successful pregnancy. Although this method of increasing fertility is quite effective, it also depends quite a lot on the physical condition of the woman undergoing IVF. For example, a young woman with blocked tubes is more likely to conceive than a woman over 35 years with severe endometriosis. In both cases, it is possible to become pregnant at the first try, only that the chances are different.

Such myths and misconceptions often prevent a lot of couples from seeking treatment to help them conceive. In such situations, it is best to talk to your doctor about any doubts you may have and not just depend on online material, which can often be quite misleading.

2439 people found this helpful

Know If You Are IVF Ready!

Dr. Prerna Gupta 86% (10 ratings)
MBBS, MD - Obstetrtics & Gynaecology, MRCOG , Fellowship In ART
IVF Specialist, Delhi
Know If You Are IVF Ready!

One of the major milestones in a woman’s life is the entry into motherhood. For most women, when this does not happen in the natural logical sequence of things, there is anxiety and a lot of pressure from family and friends.

However, with advancements now, there are options like intrauterine insemination and in vitro fertilization (IUI and IVF) available, which can help increase the chances of conception and pregnancy. IVF is where the egg is retrieved from the woman’s womb, fertilized externally and then transplanted back into the uterus where it grows to full term. However, there are always unanswered questions like how long to wait before going for IVF, is it the right procedure for me, etc.

Read on to know to find answers to some of these. 

  1. Maternal age: As a woman reaches 35 and a man reaches 40, the fertility rates drop significantly. The chances that a woman at 35 will conceive is about 20%, which goes down to 5% if the woman is 40. However, this rate can be significantly increased by using IVF. The quality of the egg would gradually deteriorate, and so if a woman is nearing 40, it is better to consider IVF as the ovarian reserve would be optimal with IVF.
     
  2. Failed intrauterine insemination: In couples who have problems with the sperm reaching the uterus, intrauterine insemination (IUI) is first attempted. However, if 3 or more attempts of fail, it is time to consider IVF.
     
  3. Duration of inability to conceive: While some couples conceive quite promptly in a month or two, most take about 6 to 8 months of unprotected sex to conceive. Therefore, IVF can be an option if you are failing to conceive even after a year. Less than a year, don’t fret. Take it easy and it might just do the trick.
     
  4. Medical health: Both the partner’s medical health should be taken into account. Lifestyle changes like smoking, alcohol abuse, drug abuse should be considered, which can account for poor sexual performance and therefore lead to an inability to conceive. Health conditions like diabetes and heart disease can also lead to infertility. Hypothyroidism in women is another thing that must be ruled out, as it often leads to an inability to conceive.
     
  5. Sexual problems with the partner: One of the first things to do before going for IVF is to check that the male does not have any issues. Be it erection issues or ejaculation issues or sperm issues, they need to be ruled out. Sperm quality, quantity, and motility have to be analyzed, and if they are optimal, IVF can be considered.
1251 people found this helpful

IVF - Who Are Eligible For It?

Dr. Sameer Pahlajani 88% (27 ratings)
MBBS
IVF Specialist, Raipur
IVF - Who Are Eligible For It?

One of the major milestones in a woman’s life is the entry into motherhood. For most women, when this does not happen in the natural logical sequence of things, there is anxiety and a lot of pressure from family and friends.

However, with advancements now, there are options like intrauterine insemination and in vitro fertilisation (IUI and IVF) available, which can help increase the chances of conception and pregnancy. IVF is where the egg is retrieved from the woman’s womb, fertilised externally and then transplanted back into the uterus where it grows to full term. However, there are always unanswered questions like how long to wait before going for IVF, is it the right procedure for me, etc.

Read on to know to find answers to some of these.

  1. Maternal age: As a woman reaches 35 and a man reaches 40, the fertility rates drop significantly. The chances that a woman at 35 will conceive is about 20%, which goes down to 5% if the woman is 40. However, this rate can be significantly increased by using IVF. The quality of the egg would gradually deteriorate, and so if a woman is nearing 40, it is better to consider IVF as the ovarian reserve would be optimal with IVF.
  2. Failed intrauterine insemination: In couples who have problems with the sperm reaching the uterus, intrauterine insemination (IUI) is first attempted. However, if 3 or more attempts of fail, it is time to consider IVF.
  3. Duration of inability to conceive: While some couples conceive quite promptly in a month or two, most take about 6 to 8 months of unprotected sex to conceive. Therefore, IVF can be an option if you are failing to conceive even after a year. Less than a year, don’t fret. Take it easy and it might just do the trick.
  4. Medical health: Both the partner’s medical health should be taken into account. Lifestyle changes like smoking, alcohol abuse, drug abuse should be considered, which can account for poor sexual performance and therefore lead to an inability to conceive. Health conditions like diabetes and heart disease can also lead to infertility. Hypothyroidism in women is another thing that must be ruled out, as it often leads to an inability to conceive.
  5. Sexual problems with the partner: One of the first things to do before going for IVF is to check that the male does not have any issues. Be it erection issues or ejaculation issues or sperm issues, they need to be ruled out. Sperm quality, quantity, and motility have to be analysed, and if they are optimal, IVF can be considered.
5978 people found this helpful

INVO - Know Advantages Of It!

Dr. Rutvij Dalal 89% (23 ratings)
MBBS, DGO, DNB (Obstetrics and Gynecology), MRCOG, FNB, Diploma in Advanced Laparoscopy, Fellowship in Human Reproduction and Assisted Reproduction
IVF Specialist, Delhi
INVO - Know Advantages Of It!

INVO (intravaginal culture of oocytes), also called IVC (Intravaginal culture) is an abetted procedure of reproduction where early embryo development and oocyte fertilization are carried out inside a gas penetrable, air-free plastic tool or device that is placed into the maternal vaginal chamber for incubation. It is a device that helps the future mothers to participate in the evolution and growth of their own embryos present inside their body. The device is composed of an inner cavity with a protective outer rigid shell and a rotating valve.

It can be used for IVF (In Vitro Fertilization) cycles; whether with the mother's own eggs or any donor's eggs. It provides the same successful results as conventional treatments. It works in a very simple way:- when the requisite samples to produce embryos have been acquired or when the eggs have been impregnated in the laboratory, they together with culture medium are placed into the INVOcell device and then the device is inserted into the vagina of the mother and there it is kept for two to three days (for 72 hours culture period). Throughout this time, the mother can lead a practically normal life but she needs to elude taking bath, having intercourse or flying during those days on which she is wearing it.

When fertilisation takes place, it will be the mother's own heat which will supply the best conditions for the proper development of the embryos. Once they are set and ready, the doctor will remove the INVO from the mother's vagina to recover the embryos. The embryos are then evaluated under the microscope to choose the healthiest-looking ones to transfer them into the uterus. Within the uterus, they will be embedded in order to begin developing.

Advantages of INVO are:

  1. It is one of the most cost-effective assisted conception treatments.
  2. In this method, the embryo incubation is more natural.
  3. Since in this whole process embryo incubation in the laboratory isn’t required, the possibility of stumbling at the laboratory is diminished.
  4. In this method, the couple experiencing the treatment is involved more.
  5. This method has similar efficacy as the IVF treatments.

Disadvantages of INVO are:

  • Since the device has to remain for three days in the mother's vagina, it causes some discomfort.
  • The patient has to spend much time in the assisted reproduction clinic and visit it more often.

The studies suggest that it could be a useful alternative choice for assisted reproduction.

2555 people found this helpful

Self-Care During IVF Treatment!

Dr. Priya Dahiya 85% (10 ratings)
MBBS, MD - Obstetrtics & Gynaecology, DNB (Obstetrics and Gynecology)
IVF Specialist, Delhi
Self-Care During IVF Treatment!

The In-vitro-Fertilization method has revolutionized reproductive technology and has made natural conception possible for so many expectant families. Despite its popularity, many individuals still fail to see to their well-being during treatment. Not only does it affect the probability and success of conception, it can also lead to further mental stress that can only be destructive towards your psychological health and perhaps your upcoming pregnancy. Here are a few ideas on how you can best take care of yourself during the treatment period:

1. Proper Sleep
A sufficient amount of sleep every night goes a long way to ensuring a peaceful state of mind. As you are anticipating conception, you should schedule your timings such that you can sleep for at least 8 hours every night. Additionally, adopt a nightly ritual so you can ease yourself into bed at a regular time every night. This allows your body clock to be standardized through the treatment period and provide you with optimal energy for the day.

2. Keep Hydrating
Fluids are ideal for flushing out the negative toxins from your body. As a result of the treatment, your body is going through a number of chemical and biological changes. Thus water and other fluids like vegetable and fruit juices help your body maintain a healthy count of blood cells and ward off side effects that may arise during the IVF treatment.

3. Acupuncture
Clinical tests have proven that certain acupuncture procedures strengthen the flow of blood into the uterus and the ovaries. Most specialists recommend that you undergo a session of acupuncture the day of the embryo transfer so that you do not activate your stress hormones. As IVF treatments often become quite trying for the couple in question, you might want to try this method to release anxiety.

4. Take Walks
Though it is not recommended that you exert yourself too much physically, engaging in light walks should only help you ease into your IVF cycle. Not only will it maintain your balance and coordination, it can also improve your mood and help you maintain an appropriate weight for conception.

5. Journal
Even if you may not realize it at the time, this period could turn out to be one of the most significant periods of your life. Becoming a mother is a complex challenge yet a wonderful privilege and you might want to document your experiences while you are going through the treatment. Not only is it incredibly soothing, but it might also help you prepare for your upcoming journey by letting you recognize and accept your emotions.

3250 people found this helpful

IVF - Know Misconception About It!

MD Gynaecology
IVF Specialist, Kolkata
IVF - Know Misconception About It!

In vitro fertilization or IVF is deemed as one of the wonder treatments for couples who are facing infertility issues. Whether it is due to poor sperm quality of blocked fallopian tubes, IVF has proven to be a safe and effective solution. However, like with all new techniques, IVF also has some myths which need to be understood before signing up for the procedure. With so much at stake in terms of finances and time, understanding the process will help set realistic expectations and improve the success rate of IVF.

Myth 1: High success rate. While IVF has very high success rates, some women just fail to get pregnant. This could be about 5% of the women and may not be attributable to any particular cause. Each woman responds differently, and failure to conceive through IVF could be due to no explainable cause. What is interesting is that though the first attempt failed, subsequent attempts may be successful. Failing the first cycle does not mean failure in subsequent cycles. Also, the success rate differs from clinic to clinic, and so choose one which has a proven track record and good success rates. It should not just have good doctors but also the essential technology and infrastructure to support the IVF technique.

Myth #2: IVF leads to multiple births. While achieving multiple births is easier through IVF, it always does not lead to multiple births. Multiple embryos are implanted, only to improve the chances of success. It does not necessarily translate into multiple births. In women over 38 years of age, it is mandatory to only transfer a single embryo as multiple births are very likely to be complicated.

Myth #3: Rest and time off work. It is believed that IVF has a higher success rate with proper rest and time off work. Rest is definitely required the first few days after embryo transplant but it definitely later assumes a normal course of things. It is not that too much time off work is required, just because you had an IVF. Your body might be different and require more rest, but that could have been the case even with a normal pregnancy.

Myth #4: The medications with IVF are going to have lots of side effects. While the hormones given to promote egg release do have their side effects of making you feel moody and emotional, it is only transient. Once the egg release happens, fertilization is done, and embryo transplant is done, then things should settle down. The effects should wear down once the embryo is implanted and then things should settle down. Of course, pregnancy brings its own hormonal changes, which will run their course through pregnancy.

5071 people found this helpful
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