On world's IVF and world embryologists day, let's thank to poineers in IVF who took efforts to make it a reality and lets thanks to all those patients who believed in miracle and make it happen by constant trust and persistence understanding limitations and blessings both
We thank all embryologists who tirelessly work in embryology labs creating dreams (embryos) of couples like brahma. They work behind screens but are lifeline of any IVF centre
Let's hope new innovations to come up to make it with in reach of everyone and making consistent endeavors to spread joy of parenthood!
Diseases which are caused by some sort of genetic mutations in the mitochondria, can be quite deadly. This is the reason why Mitochondrial Replacement Therapy, also known as Three-Person IVF is being seen as a much more desired option for those women, who carry mitochondrial mutations.
Almost all the genes in a cell remain trapped in the nucleus but a small fraction of them remain present in the mitochondria as well. During the fertilisation of eggs, the genes in the egg’s nucleus get combined with the genes in the nucleus of the sperm, which in turn creates a new cell. On the other hand, mitochondrial genes are involved in this mixing. Rather they are passed on from mother to child.
The main reason behind three-person IVF is to help find a way, so that the mitochondrial genes can be replaced in an affected cell of the egg prior to the time they get passed on to the child. This is carried out when the egg cell of the donor gets acquired and the nucleus is removed from the cell, hence leaving the cell with healthy mitochondria. After that, the mother’s nucleus, which stays unaffected, is removed and gets placed in the donor’s egg cell, thereby creating an egg cell which must contain healthy genes not only in the nucleus but also in the mitochondria.
Genes Are Complex in Nature
Ethics Comes First
The review of the ethics related to MRT or Three-Person IVF came up with the conclusion that if the procedure was safe, then it could be considered as ethical. In other words, they concluded that if the trials carried out on humans showed that the treatment undertaken was safe, then it could also be considered as ethical as well.
In case you have a concern or query you can always consult a specialist & get answers to your questions!
Suffering from the problem of infertility can be a heartbreaking as well as a very frustrating process but still with different kinds of IVF treatments available today, a lot of women can realize their dreams of having their own family. In Vitro Fertilization is a laboratory procedure where the sperm and egg are fertilized outside the body. It has been more than 35 years since the first baby was born through this process of IVF and now it has become the go-to method for treatment regarding reproduction, which assists in the birth of over 5 million babies. With the availability of different kinds of IVF treatments currently, to navigate one’s way through the in vitro fertilization process can seem to be quite confusing as well as intimidating.
Now, we take a look at the difference between the types of IVF treatments and see if they are right for a woman.
Different Types of IVF - Since the time IVF came into being, more than three decades ago, it has become the leading form of assisted reproduction, having an estimated amount of 70000 babies per year getting conceived through this procedure. The procedure of IVF involves a really complex series of procedures where an egg gets removed from the ovaries of a woman and fertilized with sperm in a laboratory. The fertilized egg, which is called an embryo then, gets returned to the womb of the woman for its growth and development.
At the time of treatment, the retrieval of eggs and fertilization take place just like they are done in any other IVF process. The only difference lies in the stimulation part, which is lot less in this case compared to regular In Vitro Fertilization. Despite Mini IVF being suggested as a gentler approach to IVF, some researchers feel that less number of eggs might reduce the possibility of getting success.
Despite the positives, certain fertility experts send out a warning due to the significantly low chance of pregnancy with this process. In case you have a concern or query you can always consult an expert & get answers to your questions!
Egg Freezing, which is also known as mature oocyte cryopreservation, refers to the method through which reproductive potential is restored among women. Eggs get harvested from the ovaries, frozen and in an unfertilized manner and are stored for purpose of using them later on. The egg freezing procedure is recommended for those women, who would like to delay conceiving baby due to various kinds of reasons.
Before the freezing of eggs, it is important to first retrieve the eggs. Let us look at how the eggs are retrieved, followed by the procedure of egg freezing through two different ways.
Retrieval of Egg
Egg Retrieval takes place just like it is done in case of in vitro fertilization (IVF). Women would need to be put under medication for hormones or through injections, which shall lead to the stimulation of ovaries, leading to more eggs getting matured. After this women would receive the necessary medication to stimulate ovulation and then the extraction of eggs takes place through the use of a needle. Specialists perform this whole procedure by putting women under the effect of anaesthesia and are also guided by ultrasounds. Once the extraction is completed, the freezing takes place.
There are two different techniques involved in the egg freezing process. They include:
Slow Egg Freezing Method
A substance called cryoprotectant is used in order to protect the biological tissues from getting damaged out of freezing. This slow freezing method of getting eggs frozen relies on low initial concentrations of cryoprotectant. The cryoprotectant in low concentration is introduced when the egg is at a relatively warm temperature and still continues to experience the usual functions of a living cell. Then the cryoprotectant would spread all throughout thus fill the egg, hence replacing most of the water inside the egg. The egg is then inserted into a small container made of plastic and ultimately get placed inside a cooling chamber. The lowering of temperature, to around -6 degree centigrade, takes place through injecting very tiny amounts of liquid nitrogen into the cooling chamber. The cooling process is controlled by a computer.
The main purpose of these techniques is to avoid ice crystals from getting formed in the egg. During the spreading of the cryoprotectant, if the ice crystals are still present, they can cause damage to the egg and hence the egg may not survive the process of thawing. Then the temperature is lowered further to around -32 degree centigrade. By this time, the egg’s metabolic rate becomes slow. The container where the egg was placed, is then dipped inside the liquid nitrogen, forming a solid.
Rapid Egg Freezing Method or Vitrification
At the time of rapid freezing method, there is high concentration of initial cryoprotectant whereas the cell remains at room temperature. The egg is unable to stay for long in this temperature and thus gets poured immediately onto the liquid nitrogen. Cryoprotectant spreads at a rapid rate so as to avoid ice-crystal from getting damaged. Vitrification is a very new method for freeing eggs. Recent research has shown that vitrification of eggs largely improves the possibility for survival after thawing and the rates of pregnancy.
IVF treatment is important as it helps many patients who would be otherwise unable to conceive. There are many reasons why IVF treatment is necessary. They are as follows.
We hope this article has been helpful in addressing your queries regarding IVF treatment and the need for it. In case you have a concern or query you can always consult an expert & get answers to your questions!
There are many different modes of contraception available to women today. Tubal ligation is considered the most effective amongst these. This involves permanently blocking the fallopian tubes by clipping, cutting or burning them. The only downside to this form of contraception is its permanence. Conceiving a child after tubal ligat ion is difficult but not impossible. The two modes of treatment available to women who have undergone this procedure are tubal ligation reversal and IVF.
As the name suggests, a tubal ligation reversal procedure reconnects the fallopian tubes. This procedure involves making a 10-15cm incision in the lower abdomen. Tiny stitches are then used to reconnect the two blocked ends of the fallopian tubes. This procedure is usually performed while the patient is under general anaesthesia and could involve a few days hospital stay. A tubal ligation reversal procedure can also be performed as a keyhole procedure. This procedure gives a woman a chance to conceive naturally. The younger the woman is, the higher are her chances of conception after this procedure. In the case of patients over the age of 40 years, the chances of a successful conception after this procedure are very slim.
IVF or In vitro fertilization involves harvesting the eggs from the patient’s ovaries, fertilizing them in a lab and then reintroducing the embryo into the patient’s uterus. When it comes to assisted reproductive therapy, IVF is more successful than a reverse tubal ligation. Another advantage of IVF over reverse tubal ligation is the fact that with IVF the woman will still have an efficient form of birth control even after the pregnancy. IVF also does not need any hospitalization. One of the downsides of a reverse tubal ligation is the high risk of a tubal ectopic pregnancy. In this case, the fertilized egg is implanted outside the uterus. This type of pregnancy cannot usually be taken to full term and can be life-threatening for the woman.
On the flip side, IVF can often need repeat cycles which often works out to be quite expensive. These costs can be an issue for a woman who wants more than one child. In the case of reverse tubal ligation, the costs are a one-time investment.
One of the other common side effects of IVF is multiple pregnancy. For women who do not want more than one child, this can again be a problem. Thus, both forms of treatment have their advantages and disadvantages.
Realistic vs unrealistic success rates - overestimation!
IVF is a high-end treatment modality in art but it has limited success and impacted by various factors
Unrealistic expectations do result in greater disappointments which may lead patients to drop out of treatment for the next cycle
When overestimation doesn't match the reality and facts then that is another factor to add to the stress
So what's needed is to disclose an individual's predicted success rate rather than a clinic's average success rate which helps to set realistic expectations
It's a difficult task but definitely keep one clearly informed.
For this other lab and clinic, parameters need to be as per good practices guidelines!
One of the major milestones in a woman’s life is the entry into motherhood. For most women, when this does not happen in the natural logical sequence of things, there is anxiety and lot of pressure from family and friends.
However, with advancements now, there are options like intrauterine insemination and in vitro fertilization (IUI and IVF) available, which can help increase the chances of conception and pregnancy. IVF is where the egg is retrieved from the woman’s womb, fertilised externally and then transplanted back into the uterus where it grows to full term. However, there are always unanswered questions like how long to wait before going for IVF, is it the right procedure for me, etc.
Read on to know to find answers to some of these.