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Fertilisation In Vitro - Embryo Transfer (Ivf - Et) Tips

Different Types Of In Vitro Fertilisation You Must Know!

Dr. Shalini Yadav 90% (60 ratings)
MBBS Bachelor of Medicine and Bachelor of Surgery, DGO, MD - Physician, Certificate Course In Reproductive Medicine & Ivf, Basic Life Support (B.L.S), Advanced Infertility Management Training, ivf training in NUH singappre, masters in Reproductive Medicine
IVF Specialist, Gurgaon
Different Types Of In Vitro Fertilisation You Must Know!

Infertility treatment is common among couples, who are unable to conceive children through the natural process, due to health or hormonal problems. Among the infertility treatments, In Vitro Fertilisation is one of the most common methods used to help couples get rid of the problems and allow them to conceive children in an unconventional manner. This artificial treatment was successfully performed for the first time in 1978. Now let’s take a look at some of the different types of IVF Treatment:

Natural Cycle: This particular type of variation in IVF does not require stimulation of woman’s ovaries for producing several eggs for collection. Only the egg which is produced during her normal menstrual cycle gets collected and it is then merged with the man’s sperm to successfully achieve fertilisation and in the process, an embryo. This method carries with it certain advantages, like this does not involve the risk of ovarian hyperstimulation and it is accepted by certain cultures and religious groups due to the fact that no spare embryos are created, which might require to be disposed of or get it frozen.

As far as disadvantage for this type of treatment is concerned, the success rates are not that high. The statistics published by the United Kingdom’s Human Fertilisation and Embryology Authority, show that only one out of 26 women under the age of 35 could get pregnant in 2008 due to the natural cycle in vitro fertilisation.

Mild Stimulation In Vitro Fertilisation
This process is carried out just like standard in vitro fertilisation. Only exception is that the hormones used to stimulate the ovaries for producing a number of eggs, get used for a short span of time. This helps to narrow down the risk of ovarian hyperstimulation syndrome in women, who had developed this particular risk  in previous cycles of in vitro fertilisation.

Mild stimulation might help get rid of the initial treatment to suppress the menstrual cycle, as a result of which one may not find this phase of treatment to be an uncomfortable one.

Like any form of treatment, this type of in vitro fertilisation treatment is not without certain disadvantages. One of them is the fewer number of eggs available for collection and hence lesser number of embryos to choose from for transfer. Still, due to the fact that stimulation of ovaries is not done in a similar manner, one does not require to wait for so long to repeat the particular cycle of in vitro fertilisation.

The low cost of mild stimulation IVF makes it a more desirable mode of infertility treatment as compared to the standard procedure followed for bringing for the desired results.

Hence, we have discussed about the two types of in vitro fertilisation for treating the problem of infertility among males and females along with their advantages and disadvantages in great detail. In case you have a concern or query you can always consult an expert & get answers to your questions!

2908 people found this helpful

IVF(In-Vitro Fertilisation)

Dr. Richika Sahay Shukla 92% (827 ratings)
DNB (Obstetrics and Gynecology), MBBS
IVF Specialist, Delhi
IVF(In-Vitro Fertilisation)

IVF (In vitro fertilization)

In Vitro Fertilisation means Fertilisation in- glass that is fertilization outside the human body. It was initially developed for fertility in females who had blocked or unfunctional fallopian tubes. At present IVF is recommended to patients who are unable to conceive due to several other causes also.

We at India IVF Clinic try to provide you with the utmost services:

  • Your initial consultation
  • Pretreatment preparation and planning management
  • Start of oral contraceptive pills
  • Ovarian induction
  • Visits
  • Egg Maturation
  • Embryo Assessment
  • Egg retrieval
  • Embryo Transfer
  • Pregnancy test
2 people found this helpful

In Vitro Fertilisation Treatment (IVF) - What Is The Prognosis For It?

Indira Ivf 86% (46 ratings)
MBBS Bachelor of Medicine and Bachelor of Surgery
IVF Specialist, Udaipur
In Vitro Fertilisation Treatment (IVF) - What Is The Prognosis For It?

In case the fertility odds are against your favour, you can undergo a procedure called IVF or in vitro fertilisation. It is a form of fertility treatment in which the sperms and eggs are combined in a laboratory. IVF is a very common fertility treatment procedure, involving modern technology. It is carried out by many women and couples worldwide. When you are facing ovulation problems and issues with the quality of eggs, have blocked fallopian tubes or if your male partner has a low sperm count, a sperm donor’s eggs are used via IVF to become pregnant.

The overall process of IVF involves several methods and steps:

  1. Ovarian stimulation: You will have to take a fertility drug called gonadotrophin eight to fourteen days before the beginning of your menstrual cycle. This will help to stimulate your ovaries for the development of multiple, mature eggs for fertilisation. You will also be given synthetic hormones like cetrorelix and leuprolide.
  2. Development of follicle: You should be visiting your doctor frequently while having the medicines for a check-up of your blood hormone levels. Your ovaries will also be measured using ultrasound. This will allow the doctor to monitor the follicle development.
  3. Trigger shot: You will be given a trigger shot injection when the follicles are prepared. This injection leads to full maturation of the eggs, making them ready for fertilisation. The eggs require a period of 36 hours for retrieval after receiving the trigger shot.
  4. Gathering of the eggs: An anesthetic will be given to you and an ultrasound probe will be inserted via your vagina for observation of the ovaries and follicles. A thin needle will be inserted through the vaginal wall with which the eggs are removed from the follicles.
  5. Fertilisation: The eggs will be observed one final time before being combined with your partner’s sperm. Then they will be incubated overnight. Fertilisation occurs during this period and the abnormal eggs do not get fertilised. Three days after the egg retrieval, some of the successfully fertilised eggs transform into embryos composed of six to ten cells. Within five days, some of these embryos turn into blastocysts composed of fluid-filled cavities and tissue. This separates into the baby and the placenta. The most viable embryos are placed in your uterus. One to five embryos are placed in your uterus by the insertion of a catheter through the cervix. The embryo implants itself to the uterus walls. Gradually, it develops into the baby. The chances of pregnancy are higher when there are multiple embryos.

Before thinking of undergoing IVF, you must consult a doctor to know about the entire process. You also need to know whether you are fit to undergo IVF as there are several criteria you should satisfy for IVF.

In case you have a concern or query you can always consult an expert & get answers to your questions!

3467 people found this helpful

All About Embryo Transfer

Dr. Rita Bakshi 87% (2899 ratings)
MBBS, DGO, MD, Fellowship in Gynae Oncology
Gynaecologist, Delhi
All About Embryo Transfer

After the eggs are collected and fertilised in the laboratory, the embryo transfer takes place. Usually and this entirely depends on your situation, about one or three embryos of the best quality are selected to be transferred to the womb. After introduction to the uterus, the egg attaches itself to the wall of the uterus for the pregnancy to come into effect. Embryo transfer is the last step in the IVF cycle.

Procedure:
The procedure chosen for transferring embryos usually depends on the clinic chosen. But most of them involve the following steps:

  1. The eggs take two or three days to fertilise. When they are ready, the embryos with the best quality are selected. These are then transferred to your uterus.
  2. A speculum is inserted into your vagina by the doctor. Then using ultrasound for guidance, a catheter is passed through the cervix. This catheter is used to pass down the embryos into the uterus.
  3. Your lifestyle after the transfer should be docile and cause you minimum stress.
  4. A pregnancy blood test will be given to you two weeks after the transfer. If the test comes out as positive, an ultrasound is scheduled after another two weeks.

Risks:
In the process of transferring the embryo, there are no significant risks involved. There might be problems during passing the embryos through the catheter, if you never have had a baby before or your cervix was not assessed before the IVF cycle was initiated.

Chances of Successful Pregnancy:
With age, female fertility declines. It helps if you are younger when using your own eggs. After a survey it was found that women:

  1. aged below 35 have 40.6% chance of success
  2. aged between 36-37 have 35.5% chance of success
  3. aged between 38-39 have 28.1% chance of success
  4. aged between 40-42 have 21.2% chance of success
  5. aged between 43-44 have 11.2% chance of success
  6. aged 45 and over have 3.4% chance of success. If you wish to discuss about any specific problem, you can consult a Gynaecologist.
3494 people found this helpful

A Closer Look Into Embryo Transfer Procedure For IVF

Dr. K.D Nayar 87% (748 ratings)
MD - Obstetrtics & Gynaecology, DGO, Dip.Obst.(Ireland), FICOG
IVF Specialist, Delhi
A Closer Look Into Embryo Transfer Procedure For IVF

Among the assisted reproductive techniques, In Vitro Fertilization (IVF) is quite popular and offers hope when other infertility procedures fail to work. The procedure involves the female egg being combined with the male sperm outside the body (in vitro condition), and as a final step, the grown embryo is placed inside the uterus.

Chances of getting pregnant is dependent upon Embryo Quality and Endometrial receptivity.

Embryo transfer is a crucial step of the procedure, and following is an account of the process that would give you a detailed insight into what really happens before and after embryo transfer.

The entire process involved-
Before an embryo is transferred, a series of procedures happen.

Step 1: (Ovarian Stimulation)
In the very first step of embryo transfer, the patient undergoing the IVF treatment is given injections containing medicines that are meant to boost the development of the eggs in the follicles of the ovary.

Step 2: (Egg retrieval)
As the follicles start to mature or develop completely, the eggs are removed carefully.

Step 3: (Fertilization)
In the designated environment, the collected eggs are then fused with the collected sperm to form the embryo.

Step 4: (Incubation)
After the successful fertilization is successful, the embryos are cultured in an incubator.

Step 5: (Choose the best embryo for transfer)
If the process is successful and once embryos are formed, the good quality embryo is chosen from them and then transferred into the uterine cavity to complete the procedure.

Are there any risks?
Embryo transfer is a critical step of the infertility procedure and would need an expert to handle the process. There are a few risks associated with the embryo transfer procedure. However, those risks are very minimal. One such associated risk is the embryo getting implanted in the wrong place, for example in the fallopian tube. Another issue that could occur is the loss of embryos during the procedure of transferring them from the in vitro environment to inside of the uterus.

Is it a painful process?
The embryo transfer is similar to a pap smear and would need no anaesthesia for the woman, however, some women prefer to be on sedation during the process. The entire procedure of embryo transfer is a painless one, though some women may experience mild cramping which is quite normal.

Precautions to be taken after embryo transfer-
After the embryo has successfully been transferred to the uterus, the patient must lie on her back for a while before leaving the clinic. Also, the woman is advised rest and limit physical activity.

The chances of getting pregnant increases with the quality of embryo, and hence it is imperative that your doctor chooses the best quality embryo for transfer into the uterus. Also, the position of placing the embryo is extremely important. You can discuss with your doctor regarding these aspects while you are undergoing the treatment. In case you have a concern or query you can always consult an expert & get answers to your questions!

1981 people found this helpful

Facing trouble conceiving? 3 Reasons you should consider IVF (In Vitro Fertilisation)

Dr. Sharda Jain 89% (57 ratings)
FIMSA, FICOG, MNAMS (Obstetrtics & Gynaecology) , MD - Obstetrics & Gynaecology, MBBS
Gynaecologist, Delhi
Facing trouble conceiving? 3 Reasons you should consider IVF (In Vitro Fertilisation)
Facing trouble conceiving? 3 Reasons you should consider IVF (In Vitro Fertilisation)

In vitro fertilization (IVF) is a medical procedure that side-steps the sexual act of conceiving and helps infertile couples, conceive a biological child. It involves the manual process of fertilization by combining an egg and sperm in the laboratory and then implanting the embryo into the female to impregnate her.

The inability to give birth through the natural way is caused due to complications like: blocked fallopian tubes, unexplained infertility, polycystic ovary syndrome or PCOS, endometriosis: where parts of the womb lining grow out of the womb, premature ovarian failure and so on.

If you or your partner is having trouble conceiving, you should opt for in vitro fertilization. It holds benefits like-

1. High success rates: Women who underwent in vitro fertilisation using fresh embryos of their own fresh eggs, the projected live birth percentage was 32.2% for those under 35 years, 27.7% for women aged between 35 and 37 years, lowering to 5.0% in 43 to 44 year olds and 1.9% for ages above 45. It has been proved that a female’s ability to conceive decreases with age. If infertility is detected at a younger age, the process of IVF is highly advantageous and successfully results in childbirth.

2. Proven track record: Technology has come a long way since the first baby via IVF Louise Brown was born in 1978 using a natural IVF. Medical techniques have advanced to create safer and successful treatment. The usage of the safest forms of IVF with low drug regimens today, have prevented side effects such as ovarian hyperstimulation syndrome (OHSS).

3. Harvests multiple eggs: If you are planning to have more than one child, via IVF you can freeze multiple eggs for future use. Unused or spare embryos can be donated to medical organisations for research purposes or to another couple willing to have a child.
IVF has proven successful in giving couples a wholesome and happy life.

3270 people found this helpful

Different Types Of In-Vitro Fertilisation!

Garbhagudi Ivf Centre 92% (83 ratings)
Fellowship in Reproductive Medicine & ART
IVF Specialist, Bangalore
Different Types Of In-Vitro Fertilisation!

Infertility treatment is common among couples, who are unable to conceive children through the natural process, due to health or hormonal problems. Among the infertility treatments, In Vitro Fertilisation is one of the most common methods used to help couples get rid of the problems and allow them to conceive children in an unconventional manner. This artificial treatment was successfully performed for the first time in 1978.

Now let’s take a look at some of the different types of IVF Treatment:

  • Natural Cycle 

This particular type of variation in IVF does not require stimulation of woman’s ovaries for producing several eggs for collection. Only the egg which is produced during her normal menstrual cycle gets collected and it is then merged with the man’s sperm to successfully achieve fertilisation and in the process, an embryo.

This method carries with it certain advantages, like this does not involve the risk of ovarian hyperstimulation and it is accepted by certain cultures and religious groups due to the fact that no spare embryos are created, which might require to be disposed of or get it frozen.

As far as disadvantage for this type of treatment is concerned, the success rates are not that high. The statistics published by the United Kingdom’s Human Fertilisation and Embryology Authority, show that only one out of 26 women under the age of 35 could get pregnant in 2008 due to the natural cycle in vitro fertilisation.

  • Mild Stimulation In Vitro Fertilisation

This process is carried out just like standard in vitro fertilisation. Only exception is that the hormones used to stimulate the ovaries for producing a number of eggs, get used for a short span of time. This helps to narrow down the risk of ovarian hyperstimulation syndrome in women, who had developed this particular risk  in previous cycles of in vitro fertilisation.

Mild stimulation might help get rid of the initial treatment to suppress the menstrual cycle, as a result of which one may not find this phase of treatment to be an uncomfortable one.

Like any form of treatment, this type of in vitro fertilisation treatment is not without certain disadvantages. One of them is the fewer number of eggs available for collection and hence lesser number of embryos to choose from for transfer. Still, due to the fact that stimulation of ovaries is not done in a similar manner, one does not require to wait for so long to repeat the particular cycle of in vitro fertilisation.

The low cost of mild stimulation IVF makes it a more desirable mode of infertility treatment as compared to the standard procedure followed for bringing for the desired results.

Hence, we have discussed about the two types of in vitro fertilisation for treating the problem of infertility among males and females along with their advantages and disadvantages in great detail. In case you have a concern or query you can always consult an expert & get answers to your questions!

3195 people found this helpful

Sequential Embryo Transfer

Dr. Richika Sahay Shukla 92% (827 ratings)
DNB (Obstetrics and Gynecology), MBBS
IVF Specialist, Delhi
Sequential Embryo Transfer

Sequential embryo transfer-(SET) is an improved method of increasing pregnancy rates and implantation rates in infertile couples.  According to the  American Society for Reproductive Medicine (ASRM), the average  pregnancy rate is about 20% for patients undergoing in vitro fertilization (IVF) treatment.  Patients undergoing SET have a pregnancy rate of over 50%!     SET is the transfer of two groups of embryos in the same menstrual cycle of a woman undergoing IVF treatment for infertility.  One group of embryos-the best looking and fastest growing embryos are transferred to the uterus 2 or 3 days after the oocytes (human eggs) are collected from the ovary.  The second, more highly developed, group of embryos are transferred to the uterus a few days later-when at least one embryo has reached the expanded blastocyst stage-an advanced stage when an embryo is about to hatch from its shell called the Zona Pellucida  and attempts to implant in the lining of the uterus called the endometrium.  SET has an increased implantation rate ( embryos implanting from the total number of embryos).

2 people found this helpful

Frozen Embryo Transfer

Dr. Richika Sahay Shukla 92% (827 ratings)
DNB (Obstetrics and Gynecology), MBBS
IVF Specialist, Delhi
Frozen Embryo Transfer

Frozen Embryo Transfer

Freezing Embryos

Any excess healthy embryos from the IVF process can be frozen, in case more than one treatment cycle is needed. Freezing embryos, also known as cryopreservation, takes place for some 60% of all patients having IVF treatment “ and frozen embryo transfers accounts for around 50% of all IVF births in our program.

Why do we freeze embryos?

Embryo freezing provides more opportunities for a pregnancy from each IVF stimulated cycle. For example, if a number of normal embryos are obtained in an IVF cycle, we might suggest transferring one or two of them and freezing the other four or five. This would generally allow further embryo transfers in later cycles without the need to undergo a full stimulated IVF cycle if pregnancy did not occur in the first cycle. If a baby is conceived in the stimulated IVF cycle then the frozen embryos can be used subsequently to try for another pregnancy without the need for further hormone stimulation

Embryo freezing gives more opportunities for a pregnancy for each hormone stimulation cycle and egg collection.

During a typical IVF cycle, we’ll be able to create more than one embryo, however there are serious risks associated with multiple pregnancies, so generally we won’t transfer more than one embryo at a time.

For example, if we manage to obtain two or three normal embryos (this does not always happen) we’ll usually recommend transferring one, and freezing the others. If you do not become pregnant in that first cycle, we can transfer another embryo.

This is called a Frozen Embryo Transfer (FET), and means you won’t have to undergo another cycle of hormone stimulation and egg collection.

Storing frozen embryos

When you go through an IVF treatment cycle any excess embryos will be stored where they will be kept frozen in cryostorage until you decide to either use, donate or discard them.

How does embryo freezing work?

Embryos can be frozen from Day 2 (four cell stage) to Day 5 (Blastocyst). They are placed in thin plastic straws, sealed at both ends, and labelled with your name and identification number.

They then go into a freezing machine, where the temperature rapidly drops to -150° Celsius. The straws are then placed in goblets, and put into tanks filled with liquid nitrogen, which keeps the temperature at -196° Celsius.

Success rates with frozen embryos

many of our births, over many years, have come from the transfer of frozen and thawed embryos. On average the success rate is about 30%, but this mainly depends on the age of the woman’s eggs when the embryos are frozen.

So, if you were to freeze your embryos in your first IVF cycle at the age of 38, and then use them when you’re 42, your fertility chance will be relative to that of a 38-year-old woman rather than a 42-year-old.

What to do with any remaining embryos?

Once you feel that your family is complete, and you have no further personal use for your frozen embryos, you may decide to donate them to another couple who are unable to conceive with their own embryos. Your specialist can discuss all your options with you

Freezing embryos for fertility preservation

If you or your partner is undergoing fertility treatment for a serious illness or cancer you might consider freezing embryos for future pregnancy attempts.

SET (Sequential Embryo Transfer)

Dr. Richika Sahay Shukla 92% (827 ratings)
DNB (Obstetrics and Gynecology), MBBS
IVF Specialist, Delhi
SET (Sequential Embryo Transfer)

SET (Sequential Embryo Transfer)

Sequential embryo transfer-(SET) is an improved method of increasing pregnancy rates and implantation rates in infertile couples.  According to the  American Society for Reproductive Medicine (ASRM), the average  pregnancy rate is about 20% for patients undergoing in vitro fertilization (IVF) treatment.  Patients undergoing SET have a pregnancy rate of over 50%!     SET is the transfer of two groups of embryos in the same menstrual cycle of a woman undergoing IVF treatment for infertility. One group of embryos-the best looking and fastest growing embryos are transferred to the uterus 2 or 3 days after the oocytes (human eggs) are collected from the ovary.  The second, more highly developed, group of embryos are transferred to the uterus a few days later-when at least one embryo has reached the expanded blastocyst stage-an advanced stage when an embryo is about to hatch from its shell called the Zona Pellucida  and attempts to implant in the lining of the uterus called the endometrium.  SET has an increased implantation rate ( embryos implanting from the total number of embryos).

Not all patients have embryos that survive to the blastocyst stage. Embryos may have arrested development in the first few days after fertilization – some embryos just arrest-no matter what the laboratory conditions are- and some embryos just were not destined to become babies because of inherent problems-such as genetic defects. The window of implantation of  human embryos is between 7 to 10 days after ovulation.  After 10 days, if the embryo does not at least start to implant, the endometrial lining may start to fall apart and not be able to sustain the embryo. Therefore, any early stage embryos placed in the uterus on Day 2 or  3 must depend on the uterus for a few more days until they develop to the blastocyst stage. Only the blastocyst stage embryo can implant in the uterus.

We believe -

Embryos talk to the uterus!

SET may be better than just one transfer for many patients for many reasons: First,  embryos communicate with the uterus using hormones called cytokines.  The presence of these cytokines can help the uterus prepare for implantation.  The exact makeup of fluids in the oviduct and uterus of each patient may be impossible to determine.  Perhaps the embryo  can tell the uterus what it needs to implant and develop. The presence of one group of embryos on Day 3 may help the implantation of the second group of embryos by getting the uterus properly prepared.  SET also provides a better method of selecting the best of the extra embryos to transfer and decreases the need to cryopreserve (freeze) extra embryos that may not be survivors. Obviously, the ability to decide which embryos are the best increases the chance of implantation and pregnancy.  Blastocysts not transferred fresh can still be cryopreserved and thawed later for a frozen embryo transfer (FET).

1 person found this helpful
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