Lybrate Logo
Get the App
For Doctors
Login/Sign-up
Last Updated: Aug 29, 2019
BookMark
Report

Diabesity

Profile Image
Dr. Jagruti ParikhEndocrinologist • 34 Years Exp.M.D. Internal Medicine
Topic Image
Over the years understanding of Diabetes has shifted from pancreas to adipocytes (fat cells). Some times with normal insulin level or with more than normal insulin people present with diabetes. This phenomenon is medically known as insulin resistance.
Science has now discovered that virtually everything to do with weight loss for both men and women is controlled by one master hormone. This hormone that controls 100% of your body’s ability to burn fat is Leptin. Researchers recently discovered that women naturally have twice as much of the fat burning hormone Leptin in their body compared to men, thus making it difficult for women to lose weight compared to men. You become leptin-resistant by the same general mechanism that you become insulin-resistant – by continuous overexposure to high levels of the hormone. If you eat a diet that is high in sugar (particularly fructose), grains, and processed foods – the same type of diet that will also increase inflammation in your body – as the sugar gets metabolized in your fat cells, the fat releases surges in leptin.
Newer methods of managing diabetes and obesity –Diabesity is centered around this hypothesis which many times termed as central obesity ( white fat cells and brown fat cells ) cancer-boosting "white" fat cells to less harmful "brown" fat (a heat-generating type of fat that burns energy instead of storing it. while researchers investigate the pharmaceutical avenues to convert white fat cells to brown in an effort to reduce the potential for cancer growth, other research has already shown that this can likely be achieved through exercise.
Thus normal blood sugar with diet and exercise-lifestyle modification can increase your brown fat cells which in turn helps in reducing fat storage, reducing insulin resistance and leptin resistance and obesity.