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All About Lupron IVF Calendar

Dr. Rita Bakshi 89% (2903 ratings)
MBBS, DGO, MD, Fellowship in Gynae Oncology
Gynaecologist, Delhi  •  36 years experience
All About Lupron IVF Calendar

Hormones agonists (receptor activating chemicals) that release gonadotropin hormones produced by the pituitary gland (GnRH) act quickly to remove luteinizing hormone (LH) and follicle stimulating hormone (FSH) from the pituitary gland. Lupron is a kind of GnRH agonist that is used to start the IVF cycle, especially if your ovaries need controlled stimulation. 

Lupron is injected intramuscularly. Lupron injections are given to women who undergo the gonadotrophin therapy, which stimulates the ovaries. Lupron mimics the structure of the GnRH, so when it is injected, it triggers the production of LH and FSH. When the pituitary gland realises the difference between GnRH and Lupron, it dramatically reduces the biological production of both the follicle stimulating and luteinizing hormone. This condition is called the pituitary down regulation and this continues as long as the Lupron is being administered. Lupron slowly, but steadily, lowers the production of estrogen.

The reason for administering Lupron is to stop premature escalation of LH. Women who are older and resistant to ovarian stimulation or who have poor ovarian reserves (the capacity to produce eggs) are usually given the Lupron therapy. Too much of the luteinizing hormone can harm the follicular production, which in turn damages the quality of egg production and later, embryo development. Lupron is injected to stop the premature luteinisation of the follicles, and it is stopped before the egg retrieval procedure.

The Lupron IVF Calendar:
To help explain the treatment, a hypothetical menstrual cycle of 28 days is taken:

  1. Days 1-7: Your menstrual cycle begins and the Lupron treatment starts (you are usually given Lupron injections)
  2. Day 8: Your periods start and the Lupron treatment continues
  3. Day 9: FSH injections are started while you are still on the Lupron injection; a blood test and ultrasound is scheduled today as well
  4. Day 10-13: The FSH and Lupron are administered together for the next seven days
  5. Day 14-15: A blood test and ultrasound is scheduled again on the fourteenth day
  6. Day 16: This will be the last day of your FSH and Lupron treatment; another blood test and ultrasound will be scheduled and HCG (Human Chorionic Gonadotrophin) injection will be administered which causes normal ovulation
  7. Day 18: On this day, the egg retrieval procedure is done. If you wish to discuss about any specific problem, you can consult a Gynaecologist.
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