Hormones agonists (receptor activating chemicals) that release gonadotropin hormones produced by the pituitary gland (GnRH) act quickly to remove luteinizing hormone (LH) and follicle stimulating hormone (FSH) from the pituitary gland. Lupron is a kind of GnRH agonist that is used to start the IVF cycle, especially if your ovaries need controlled stimulation.
Lupron is injected intramuscularly. Lupron injections are given to women who undergo the gonadotrophin therapy, which stimulates the ovaries. Lupron mimics the structure of the GnRH, so when it is injected, it triggers the production of LH and FSH. When the pituitary gland realises the difference between GnRH and Lupron, it dramatically reduces the biological production of both the follicle stimulating and luteinizing hormone. This condition is called the pituitary down regulation and this continues as long as the Lupron is being administered. Lupron slowly, but steadily, lowers the production of estrogen.
The reason for administering Lupron is to stop premature escalation of LH. Women who are older and resistant to ovarian stimulation or who have poor ovarian reserves (the capacity to produce eggs) are usually given the Lupron therapy. Too much of the luteinizing hormone can harm the follicular production, which in turn damages the quality of egg production and later, embryo development. Lupron is injected to stop the premature luteinisation of the follicles, and it is stopped before the egg retrieval procedure.
The Lupron IVF Calendar:
To help explain the treatment, a hypothetical menstrual cycle of 28 days is taken: