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Afrezza (Insulin Inhalation)

Written and reviewed by
MBBS,CCA,DCA,AASECT,FPA,AAD,F.H.R.SM.I.M.S
General Physician, Gorakhpur  •  19 years experience
Afrezza (Insulin Inhalation)

Afrezza - the only inhaled insulin for diabetes.

Afrezza® is an inhaled human insulin indicated to help improve glycemic control in adults with diabetes mellitus.

 

Afrezza is a rapid-acting, inhaled insulin used to control high blood sugar in adults with type 1 and type 2 diabetes. The product consists of a dry formulation of human insulin delivered from a small and portable inhaler. 

Administered at the beginning of a meal, afrezza dissolves rapidly upon inhalation to the lung and delivers insulin quickly to the bloodstream. Peak insulin levels are achieved within 12–15 minutes of administration. Afrezza is available in 4-unit and 8-unit single dose cartridges of insulin powder that can be used, as prescribed by a health care professional, in combination with other diabetes medications to achieve target blood sugar levels. For afrezza doses exceeding 8 units, patients may use a combination of 4 unit and 8 unit cartridges. Other sizes of cartridges are being considered. The disposable inhaler can be used for up to 15 days, should be kept in a clean, dry place with the mouthpiece cover on and may be wiped with a clean, dry cloth if needed.

Limitations of use

Do not use afrezza as a substitute for long-acting insulin; 

Afrezza must be used in combination with long-acting insulin in patients with type 1 diabetes.

Do not use afrezza to treat diabetic ketoacidosis. Afrezza is not recommended in patients who smoke or who have recently stopped smoking.

Important safety information for afrezza

Warning: risk of acute bronchospasm in patients with chronic lung disease

 

Acute bronchospasm has been observed in patients with asthma and COPD using afrezza. Afrezza is contraindicated in patients with chronic lung disease such as asthma or copd. Before initiating afrezza, perform a detailed medical history, physical examination, and spirometry (FEV1) to identify potential lung disease in all patients.

Do not use afrezza if you have problems with your lungs, such as asthma or COPD. Do not use afrezza during a low blood sugar reaction (hypoglycemia). If you are allergic to any of the ingredients in afrezza, do not use afrezza as this may cause a significant and severe allergic reaction. 

 

Resources:-

Afrezza patient starter kit

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