Hi, my son's age is 1.5 yr. He was suffering from periodic fever (as per doctor) which was recurrent for 2 months and was coming every alternate week. Now he is ok but in the due course we have done some tests of cbc, crp, mp dual antigen and urine re & culture. Urine test is ok with a scanty bacteria shown. Blood test is ok hb is 12.6 and the other components are ok only the concern is that the rbc is a bit small. Doctor prescribed iron tonic for 6 months. My question is is this a concern for having rbc a bit small? as doctor said to keep in observation for sometime. My baby is active with no weight loss or growth hamper till date. Please advice. Thank you in advance for your help.

Dr. Sajeev KumarGeneral Physician33yrs exp

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Please send all reports for proper advice. You can send them by ask privately option. The periodic fever syndromes' (also known as autoinflammatory diseases or autoinflammatory syndromes) are a set of disorders characterized by recurrent episodes of systemic and organ-specific inflammation. Unlike autoimmune disorders such as systemic lupus erythematosus, in which the disease is caused by abnormalities of the adaptive immune system, patients with autoinflammatory diseases do not produce autoantibodies or antigen-specific t or b cells. Instead, the autoinflammatory diseases are characterized by errors in the innate immune system. The syndromes are diverse, but tend to cause episodes of fever, joint pains, skin rashes, abdominal pains and may lead to chronic complications such as amyloidosis. Most autoinflammatory diseases are genetic and present during childhood. The most common genetic autoinflammatory syndrome is familial mediterranean fever, which causes short episodes of fever, abdominal pain, serositis, lasting less than 72 hours. It is caused by mutations in the mefv gene, which codes for the protein pyrin. 

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