What is the main reason of increasing uric acid in our body, and what are the main side effects of it?
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Mr Gobindo, Uric acid increase in the serum is caused by a number causes such as : Genetic defect- deficiency of an enzyme Hypoxanthine Phosphoribosyl Transferase which eliminates uric acid, this build blood levels of uric acid. Renal insufficiency leading to reduced excretion of uric acid. Diuretics, excess alcohol intake, presence of hypothyroidism, immune suppressant drugs, obesity, psoriasis. Purine rich diet - organ meats,red meat, high fat milk products,poultry, certain fishes like sardines, trout, herrings, scallops, mushrooms and mussels etc. Even long fasting increases uric acid level. Excess uric acid in blood if not cleared, gets deposited in and around smaller joints causing severe pain and swelling (Gouty arthritis) especially in n great toe and other joint pains
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