The actions of all these medicines are at different steps of coagulation
cascade. So the doctor decides according to the need of patient and his liver status, platelets counts, aptt level, inr ratio, prothrombin
time etc. So a fixed combination cannot be given to every patient. The mefenamic
acid and trenexa combination is used when spasmodic pain
of smooth muscles is associated with bleeding
eg. Menstrual bleeding with pain. U can consult me online privately for further questions.