My mrs has developed some semi hard roundish nodules, size of thumb prints, in her legs and one on a finger since last 6/7 months. No pain or irritation. Additionally, her ankles are bit swollen since last 1 month wherein she sometimes get itching feeling and slight pain on pressing. Rheumatologist has tested blood and urine; found nothing and has asked to do biopsy. Heard biopsy can cause aggravation/spread of nodules. Any prima facie diagnosis ? Any non-invasive test for conclusive diagnose? If biopsy is the only option, can some medication or treatment be tried? Thanks.