THE AGE OF MY FATHER IS 82. NOW HE LOST HEAMOGLOBIN RAPIDLY. HIS HB WAS 12.3 AFTER GIVING 6 UNIT BLOOD ON16/12/2014 TO 24/12/2014 BUT ON 28/01/2015 IT WAS 9.2. PLEASE GIVE ADVICE. THANK YOU.
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Pernicious Anemia Pernicious anemia (PA) is an autoimmune disorder in which the body fails to make enough healthy red blood cells (RBCs). The body requires vitamin B-12 and a type of protein called intrinsic factor (IF) to make red blood cells. Vitamin B-12, or cobalamin, is found in certain foods and medications. IF is a protein made by the stomach?s mucosal (mucus-secreting) cells, called parietal cells. When vitamin B-12 enters the body, it binds with IF. The two are then absorbed in the last part of the small intestine. In the majority of cases of PA, the body?s immune system attacks and destroys the stomach?s mucosal cells. IF can no longer be made, and vitamin B-12 cannot be absorbed. Vitamin B-12 deficiency produces a small number of overly large and ineffective RBCs called macrocytes. Because of their large size, these cells may not be able to leave the bone marrow and enter the bloodstream. The resulting decrease in oxygen-carrying RBCs in the bloodstream can lead to fatigue and weakness. According to the National Heart, Lung, and Blood Institute (NHLBI), this type of anemia is called ?pernicious? because it was once considered a deadly disease. This was due to the lack of available treatment. Today, the disease is relatively easy to treat with B-12 shots or supplements. With the best of Health
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