My father aged 68, some 8 months back was diagnosed for Spine TB and he started on AKT4 for 2 months, AKT3 for the next month but had to stop due to vision loss and following 5 months was taking Rifampicin and Isoniazid. His vision is almost back with some eye power complaint. Recent blood report shows hemoglobin at 11.5. He has recently started to complaint about burning sensation while peeing and frequent urination. His Blood urea, BUN is high and so is creatinine = 1.77. I read that Rifampicin could induce such problems. I consulted general medicine doctor and he was concerned and asked to remove azulix (sugar medicine) and include nefrolex for 5 days and then redo the KFT. however he thing rifampicin could rarely cause this kind of toxicity. FYI. He is taking 40 mg of pyridoxine, his blood work shows platelet count=130, ESR 70, CRP has come down from 67 to 8.4, LFT results are normal, His back pain is almost gone. Remarks of Hemogram: RBCs: Mild anisopoikilocytosis. Predominantly macrocytic normochromic with macroovalocytes. WBCs: Mild Leukopenia is present. Platelets: Appear mildly reduced in smear. Macroplatelets are seen. Urine has pus cells loaded.