Hi, My husband aged 51. Diagnosed case of carcinoma Colon completed 12 cycles of chemotherapy (July 2017) with FOLFOX 6 Q2 post surgery (December 2016). Relapsed again in November PetCT (29november 2017) showed soft tissue deposits in perihepatic, perisplenic, omental, mesentery, pelvis and ascites are new findings. FNAC: s/o moderately diff adenocarcinoma. Doc planned 6 cycles of chemo with Folfiri n added Avastin targeted therapy during 2nd round of chemo completed today. Please advise me the effective course of treatment to be given The patient. Whether Immunotherapy will be helpful in this case?

Immunotherapy is a new treatment approach for patients with colorectal cancer. There are currently six approved immunotherapies for colorectal cancer patients. Bevacizumab (Avastin�) and ramucirumab (Cyramza�) are drugs that target vascular endothelial growth factor (VEGF), which helps tumors form new blood vessels to get nutrients (a process known as angiogenesis). Cetuximab (Erbitux�) and panitumumab (Vectibix�) are both monoclonal antibodies that specifically attack the epidermal growth factor receptor (EGFR), which is often highly expressed on cancer cells and helps them grow. Two anti-PD-1 checkpoint immunotherapies?nivolumab (Opdivo�) and pembrolizumab (Keytruda�)?have also been approved for colorectal cancer patients with advanced, relapsed tumors that are characterized by high microsatellite instability (MSI-hi). 

1 person found this helpful