I am a 54 years old divorced male living all alone. Children well settled. No liability. After my mother expired I went into depression and also consulted a doctor for the same who advised me nexito 5 and 10 mg morning and evening along with modalert 50 mg. But as of date I have lost interest in everything and feel totally drained out mentally. The medication was ok in the starting but of no use now. Visited the doctor many times but to no positive results. I don't have any suicidal thoughts but have lost interest in everything. I do take lonazep .5 mg at night. Going to gym regularly in morning. Have lost all interest in work and don't feel like working any more. Please advise. I stay in New Delhi.

Dr. Sathya PrakashPsychiatrist13yrs exp

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Dear sir, Thanks for writing in, welcome to the forum. Depression is a complex entity with many different forms and presentations. Certain aspects of depression respond to medicines, while certain others to psychotherapy, and still others to exercise/ diet/ sleep etc. Very often, one antidepressant is initially effective/ partially effective and then loses efficacy. The correct thing to do in such a scenario is to re-evaluate the diagnosis and if that is accurate, shift to a different medicine based on the detailed history/ evaluation and combine it with psychotherapies such CBT. It is great that you are exercising regularly. I assume that blood tests including thyroid and vitamins are normal. The above suggestions will help you to proceed further. Take care!  

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