My wife age 28 having sulpitac 100 mg tablet for depression. She it taking it for last 6 months. When we check the prolactin levels as suggested by gynecology doctor it more than 200. She suggested to take MRI. Should we go for MRI or check the prolactin levels after stopping the medicine. Now her menses was not occurring still 2 months. Do prolactin levels reach above 200 due to sulpitac 100 mg. Kindly clarify.

Dr. Sajeev KumarGeneral Physician32yrs exp

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Prolactin is the hormone that stimulates milk production by the breasts. The normal prolactin level is < 20 ng/ml. In most women the tumors are detected when they are small (microadenomas) and the prolactin level is only moderately elevated (30 - 300 ng/ml. High levels of prolactin may mean that the pituitary gland is making excess prolactin for unknown reasons (idiopathic hyperprolactinemia). Other conditions that can cause high prolactin levels include pregnancy, liver disease (cirrhosis), kidney disease, and hypothyroidism. MRI is needed to find out the cause and Hyperprolactinemia may occur in patients receiving amisulpride at low dose of 50 mg/day and results in galactorrhoea, amenorrhea and sexual dysfunction. The symptom ameliorates on withdrawing the drug, switching to non-prolactin-elevating drugs, and timely management with dopamine agonist. 

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