Intralesional infiltration treatment involves local infiltration of the area around the lesion (the infected portion of the dermis along with the base of lesion) for the treatment of localized Langerhan's cell histiocytosis (LCH). As opposed to topical steroids, the intralesional steroids are useful in treating dermatological conditions which causes inflammation of the skin. These are useful as they normally deliver higher dosages of medicine on the affected site quickly, can easily bypass the thick stratum corneum and lessens the chance of skin thinning. The intralesional corticosteroid injection is directly injected under the skin or lesion by the dermatologist to treat various skin conditions such as keloids or hypertrophic scars, localized psoriasis, alopecia areata, acne cysts, or any type of localized inflammatory skin diseases. Normally, the cortisone injection for keloids scars are avoided in patients who have a history of prolonged fungal infections, active peptic ulcers, high sugar and high pressure and acute depression. The dose of the injection will depend on the intensity of the disorder and normally 0.1 to 0.2 ml in injected in each square centimetre of skin. The dose should continue for a period of 4 to 8 weeks, the injections can be repeated if the lesions are active. Patients undergoing this treatment may face some side effects such as pain, infection, small bruises, or contact allergic dermatitis.
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