Malignant fibrous histiocytoma (MFH), a type of sarcoma, is a malignant neoplasm of uncertain origin that arises both in soft tissue and bone. It can arise from any part of the body, clinically presenting as swelling, mass, pain, pathological fracture and occasional systemic features and is characterized by high local recurrence and significant metastasis.
HOW IS MALIGNANT FIBROUS HISTIOCYTOMA DIAGNOSED?
Plain radiographs will demonstrate a soft tissue mass and if arising from bone, then an aggressive destructive bony lesion. a CT scan of the chest is routinely obtained to determine the presence or absence of metastatic disease. MRI is the modality of choice for assessing soft tissue sarcomas, as it is best able to locally stage the tumour. Cells and tissues are removed during a biopsy so they can be viewed under a microscope by a pathologist to check for signs of cancer.
HOW IS MALIGNANT FIBROUS HISTIOCYTOMA TREATED?
There are different types of treatment for patients with osteosarcoma or malignant fibrous histiocytoma (MFH) of bone. Children with osteosarcoma and MFH should have their treatment planned by a team of health care providers who are experts in treating cancer in children. Four types of standard treatment are used:
• Radiation therapy
• Targeted therapy
DID YOU KNOW?
Recovery from Malignant Fibrous Histiocytoma depends on the primary tumor grade, size and respectability.