One of the rarely occurring kinds of autosomal disorders is Leukocyte Adhesion Deficiency. In this disorder, the patient would experience immunodeficiency that leads to a recurrence of infections. In simple terms, symptoms here happen based on low immunity and could range from constant fever, illnesses and also being prone to falling sick. LAD can be of various types and the most common one is LAD1.
HOW IS LEUKOCYTE ADHESION DEFICIENCY DIAGNOSED?
Diagnosis involves conducting various immune function tests. There is also a basic evaluation of the humoral immune system and the cell mediated immune system.
HOW IS LEUKOCYTE ADHESION DEFICIENCY TREATED?
Treatment is with prophylactic antibiotics, often given continuously. Granulocyte transfusions can also help. Bone marrow transplantation is the only effective treatment till date and can be curative. For patients with type II, correcting the underlying defect with fucose supplementation is recommended. Gene therapy is suggested for certain cases. Patients with mild or moderate disease can survive into young adulthood. Most patients with severe disease die by age 5, unless treated successfully with bone marrow transplantation.
DID YOU KNOW?
The disease is usually seen in one of 1,00,000 births and is not attributed to any particular kind of ethnic race or group.